Research in the Balskus Lab:

Discovering, Understanding, and Manipulating Microbial Chemistry

The vast majority of life is microbial. Estimates place the total number of microbes on Earth at 1030; for comparison, the number of stars in the universe is estimated at 1024. Survival of these organisms in diverse habitats and complex communities requires chemical innovation, and microorganisms are continually evolving elegant chemical solutions for problems inherent to their growth and survival. Understanding microbial metabolism at the molecular level is important; metabolic functions of these organisms shape the environment, impact human health, and provide us with medicinally and industrially essential molecules.

The central goal of research in the Balskus Lab is to discover, understand, and manipulate microbial chemistry. We are developing chemically guided approaches for discovering new metabolic pathways and enzymes in microbial genome sequencing data and for elucidating biochemical functions of genes linked to important biological activities. We are also exploring strategies for altering microbial metabolism using biocompatible, non-enzymatic chemical transformations that can interface with biological pathways. This work has the potential to transform both how we use DNA sequencing data to understand biology and how we can harness biology for chemical production. 

Latest News

GRC Poster Award

July 3, 2015

Kristen was given a Postdoctoral Poster Competition Award at the Bioorganic Chemistry Gordon Conference - congratulations!

Welcome to Doug Kenny

July 3, 2015

Emily and Prof. Ramnik Xavier (Broad Institute, MGH) will be co-mentoring ChemBio graduate student Doug Kenny during his PhD. Welcome Doug!

Associate Professor Promotion

July 1, 2015

Congratulations to Emily on her recent promotion to Associate Professor in the Department of Chemistry and Chemical Biology!