Research in the Balskus Lab:

Discovering, Understanding, and Manipulating Microbial Chemistry

The vast majority of life is microbial. Estimates place the total number of microbes on Earth at 1030; for comparison, the number of stars in the universe is estimated at 1024. Survival of these organisms in diverse habitats and complex communities requires chemical innovation, and microorganisms are continually evolving elegant chemical solutions for problems inherent to their growth and survival. Understanding microbial metabolism at the molecular level is important; metabolic functions of these organisms shape the environment, impact human health, and provide us with medicinally and industrially essential molecules.

The central goal of research in the Balskus Lab is to discover, understand, and manipulate microbial chemistry. We are developing chemically guided approaches for discovering new metabolic pathways and enzymes in microbial genome sequencing data and for elucidating biochemical functions of genes linked to important biological activities. We are also exploring strategies for altering microbial metabolism using biocompatible, non-enzymatic chemical transformations that can interface with biological pathways. This work has the potential to transform both how we use DNA sequencing data to understand biology and how we can harness biology for chemical production. 

Latest News

Welcome to 4 more CCB graduate students

January 4, 2015

As 2015 kicks off, we are pleased to announce that 4 new CCB graduate students have joined the lab: Samantha Cassel, Carina Chittim, Tai Ng, and Benjamin Schneider. Welcome all!

Phi Beta Kappa

December 15, 2014

Undergraduate Jonathan Marks was recently elected to Phi Beta Kappa. Congrats on this honor! 

MIT Technology Review Innovator Under 35

September 1, 2014

Emily was recently named one of this year's MIT Technology Review 35 Innovators Under 35; the entire list can be seen here. Thanks to the selection committee for this honor and for recognizing the importance of studying the chemistry of microbes!