Bui E, Rodgers R, Chabrol H, Birmes P, Schmitt L.
Is Anakin Skywalker suffering from borderline personality disorder?. Psychiatry research [Internet]. 2011;185(1):299 - .
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Neauport A, Rodgers RF, Simon NM, Birmes PJ, Scmitt L, Bui E.
Effects of a psychiatric label on medical residents’ attitudes. International Journal of Social Psychiatry [Internet]. 2011.
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Cailhol L, Bui E, Rouillon L, Bruno N, Lemoalle A, Faure K, Klein R, Lamy P, Guelfi J-D, Schmitt L.
Indication différentielle des psychothérapies adaptées au trouble de la personnalité limite. Therapeutique [Internet]. 2011;37, Supplement 1:S77 - S82.
WebsiteAbstractRésuméLe trouble de personnalité limite (TPL) représente 10 % de l’activité psychiatrique ambulatoire. Le risque de suicide est important, ainsi que l’altération du fonctionnement psychosocial. L’objectif de notre revue de littérature est de déterminer l’efficacité des psychothérapies adaptées aux sujets présentant un TPL sur la sphère affective, comportementale, le fonctionnement interpersonnel et global ainsi que sur la personnalité. Pour cela, nous avons réalisé une revue de littérature de 1990 à 2008 sur Medline recoupant les mots clefs, « borderline personality disorder » et « psychotherapy » avec les limites « randomised control trial » ou « meta analysis ». Nous avons retenu 39 résumés, dont 17 (44 %) ont été sélectionnés, après application des critères d’exclusion (méthode non contrôlée, étude centrée sur un psychotrope, étude ne correspondant pas à notre objectif). Les psychothérapies apparaissent efficaces dans la prise en charge de plusieurs aspects touchant au TPL. La thérapie comportementale et dialectique possède le plus haut niveau de preuve, notamment concernant son action sur les comportements autoagressifs. La thérapie basée sur la mentalisation possède le plus large spectre d’action. La thérapie cognitive manualisée et la formation d’inspiration systémique à la prédiction émotionnelle et à la résolution de problème offrent la faisabilité la plus importante. En l’état actuel, il existe des différences d’indication probable en fonction des symptômes cibles et des ressources sanitaires disponibles.
SummaryBackground
Borderline personality disorder (BPD) accounts for 10% of outpatient psychiatric practice. The risk of suicide attempts is high and the psychosocial impairment significant. Different theoretical streams have suggested psychotherapeutical approaches for BPD.
Objective
to examine the efficacy of psychotherapy for BPD patients on affective symptoms, behavioural outcomes, interpersonal and social functioning, as well as BPD criteria.
Methods
We reviewed the medical literature from 1990 to 2008 on Medline by combining the following keywords “borderline personality disorder” and “psychotherapy” (inclusion criteria). We restricted the analysis to “randomised control trial” or “meta analysis”.
Results
Of the 39 abstracts that came out from the search, we selected 17 (44%) after applying the exclusion criteria. According to our review, different types of psychotherapies have shown some efficacy on reducing affective symptoms and BPD criteria, as well as improving behavioural outcomes and psychosocial functioning. Dialectical behavioural therapy presents the best-documented efficacy, notably on reducing self-mutilating and suicidal behaviours (five randomized controlled trials [RCT]). Mentalization based treatment seems to be efficient on the four types of outcomes, but has been the object of only one RCT. Finally, some evidence suggests that Manual Assisted Cognitive Treatment and Systems Training for Emotional Predictability and Problem Solving are the most cost-effective and easiest to be implemented.
Conclusion
According to our review, some evidence supports an efficiency of psychotherapies in the management of several features of BPD. It is likely that, depending on the target symptoms, one type of therapy might be more efficient than another. The acceptability of these long-term treatments is however unknown.
Bui E, Delrieu J, Wagner T, Rieu J, Véry E, Letamendia C, Payoux P, Schmitt L.
Iodine-123 Fluoropropyl-Carbomethoxy-3-β-(4-Iodophenyltropane) Single-Photon Emission Computed Tomography Findings Before and After Electroconvulsive Therapy in Major Depressive Disorder With Parkinsonism. The Journal of ECT [Internet]. 2011;27(4).
WebsiteAbstractBackground: To date, only a few cases of improvement of Parkinsonism in depressed patients treated with electroconvulsive therapy (ECT) have been reported. However, no functional imaging data are available to support this finding.Objective: To describe the first observation of increase in dopamine transporter uptake after ECT.
Methods: Iodine-123 fluoropropyl-carbomethoxy-3-β-(4-iodophenyltropane) single-photon emission computed tomographic imaging was conducted in a 77-year-old depressed patient displaying symptoms of Parkinson disease (PD) before and after a series of 12 bilateral ECTs.
Results: The patient displayed improvement in PD symptoms and increase in dopamine transporter uptake after ECT.
Conclusions: Our observation suggests that the PD symptoms and decrease in striatal uptake appearing in the context of a depressive episode might warrant further attention, as they might be reversible.
Brunet A, Poundja J, Tremblay J, Bui É, Thomas É, Orr SP, Azzoug A, Birmes P, Pitman RK.
Trauma Reactivation Under the Influence of Propranolol Decreases Posttraumatic Stress Symptoms and Disorder: 3 Open-Label Trials. Journal of Clinical Psychopharmacology [Internet]. 2011;31(4).
Website Mutabaruka J, Séjourné N, Bui E, Birmes P, Chabrol H.
Traumatic Grief and Traumatic Stress in Survivors 12 Years after the Genocide in Rwanda. Stress and Health [Internet]. 2011:n/a - n/a.
WebsiteAbstractThe relationship between exposure to traumatic events and traumatic grief and the role of mediating and moderating variables [peritraumatic distress, post traumatic stress disorder (PTSD) symptoms and symptoms of depression] were studied in survivors of the genocide of Batutsi in Rwanda in 1994. One hundred and two survivors (70 women, mean age 45 ± 7.53 years) participated in this retrospective study. All of them had lost a member of their family. The severity of traumatic exposure (Comprehensive Trauma Inventory), peritraumatic distress (Peritraumatic Distress Inventory), current PTSD symptoms (PTSD Checklist), depressive symptoms (Beck Depression Inventory) and traumatic grief symptoms (Inventory of Traumatic Grief) was evaluated. A hierarchical multiple regression analysis was then conducted to examine the relative contribution of each variable to the symptoms of traumatic grief. The severity of traumatic exposure was related to traumatic grief symptoms (B = 0.06, R = 0.6, R2 = 0.36 and ß = 0.6, t = 7.54, p = 0.00). The Baron and Kenny procedure (1986) (including three separate regressions), along with the Sobel test, was used to test mediation effects. Peritraumatic distress and PTSD symptoms may be mediating variables between traumatic exposure and traumatic grief. Traumatic grief is a complex but assessable entity, where previous distress and suffering result from both psychological trauma and the loss of a loved one. Copyright © 2011 John Wiley & Sons, Ltd.
Bourredjem A, Pelissolo A, Rotge J-Y, Jaafari N, Machefaux S, Quentin S, Bui E, Bruno N, Pochon J-B, Polosan M.
A video clinical global impression scale (CGI) in obsessive compulsive disorder. Psychiatry research [Internet]. 2011;186(1):117 - 122.
WebsiteAbstractThe Clinical Global Impression scale (CGI) is frequently used in clinical research because of its face validity and ease of use but data on its reliability are scarce. Our goal was to estimate the reliability of the scale and compare reliability between face-to-face and video scoring. We analyzed 50 different video interviews recorded during 5 visits of a crossover trial to study the effect of subthalamic nucleus stimulation. Six specialized clinicians rated the CGI using these videos, providing 300 different ratings. The intraclass correlation was lower at inclusion (0.30 [0.13–0.50]) than at later visits (0.68 [0.61–0.80]). Reliability was not influenced by the patients' stimulation status. The mean of at least two independent evaluations of the video is needed to achieve an ICC greater than 0.8. The video CGI is a valid clinical outcome measure suitable for clinical trials (ClinicalTrials.gov number, NCT00169377).