Publications

In Press
Letamendia C, LeBlanc NJ, Pariente J, Simon NM, Thomas CL, Chabrol H, Chollet F, Raposo N, Schmitt L, Birmes P. Peritraumatic distress predicts acute posttraumatic stress disorder symptoms after a first stroke. [Internet]. In Press: - . WebsiteAbstract
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2012
Bui E, Rodgers R, Simon NM, Jehel L, Metcalf CA, Birmes P, Schmitt L. Body Piercings and Posttraumatic Stress Disorder Symptoms in Young Adults. Stress and Health [Internet]. 2012:n/a - n/a. WebsiteAbstract
Body piercing, which is prevalent in young adults, has been suggested to be associated with features usually related to posttraumatic stress disorder (PTSD) such as high-risk behaviours and psychopathological symptoms and might be motivated by a wish to deal with prior traumatic experiences. However, to date, no research has investigated the relationship between this practice and PTSD symptoms. The present research aims to investigate the possible relationship between body piercing and PTSD symptoms in French-speaking young adults. According to our results, having two or more body piercings was associated with a twofold increased risk for scoring above the cut-off score for PTSD on the PTSD checklist. Our findings suggest that two or more body piercings might serve as an identifiable marker for PTSD symptoms and may have important implications for clinical screening. Copyright © 2012 John Wiley & Sons, Ltd.
Dubosc A, Capitaine M, Franko DL, Bui E, Brunet A, Chabrol H, F. Rodgers R. Early adult sexual assault and disordered eating: The mediating role of posttraumatic stress symptoms. Journal of Traumatic Stress [Internet]. 2012;25(1):50 - 56. WebsiteAbstract
Although adult sexual assault has been suggested to be a risk factor for disordered eating, little is known about the pathways leading to this disorder. This study aimed to examine the mediating effect of depressive symptoms and symptoms of posttraumatic stress disorder (PTSD), in the relationship between sexual assault and disordered eating among female students. A sample of 296 French female students completed a questionnaire assessing experiences of sexual assault from age 15, PTSD symptoms, depressive symptoms, and disordered eating. Results revealed that PTSD symptoms fully mediated the effect of early adult sexual assault on disordered eating (B = 1.10, SE = 1.64), and depressive symptoms were a partial mediator of this relationship (B = 2.64, SE = 1.28). When examining both mediators simultaneously the relationship was fully mediated and neither variable emerged as a significantly stronger mediator. Our findings highlight the complex relationship between PTSD symptoms, depressive symptoms, and disordered eating following sexual assault. Further investigation into the temporal relationships between these variables would contribute to inform prevention interventions for disordered eating.
Bui E, Rodgers RF, Herbert C, Franko DL, Simon NM, Birmes P, Brunet A. The Impact of Internet Coverage of the March 2011 Japan Earthquake on Sleep and Posttraumatic Stress Symptoms: An International Perspective. [Internet]. 2012;169(2):221 - 222. WebsiteAbstract
To the Editor: On March 11, 2011, a 9.0 magnitude earthquake and tsunami struck Japan, killing 14,000 people and damaging nuclear and petrochemical plants. The immediate and intense media coverage exposed viewers across the world to disturbing images. While television coverage of a nearby disaster has been found to increase the risk for subsequent psychological distress (1), little is known about the effects of Internet coverage of a distant disaster.
Montastruc F, Sommet A, Bondon-Guitton E, Durrieu G, Bui E, Bagheri H, Lapeyre-Mestre M, Schmitt L, Montastruc J-L. The importance of drug–drug interactions as a cause of adverse drug reactions: a pharmacovigilance study of serotoninergic reuptake inhibitors in France. European Journal of Clinical Pharmacology [Internet]. 2012;68(5):767 - 775. WebsiteAbstract
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Ladois-Do Pilar Rei A, Bui E, Bousquet B, Simon NM, Rieu J, Schmitt L, Billard J, Rodgers R, Birmes P. Peritraumatic Reactions and Posttraumatic Stress Disorder Symptoms After Psychiatric Admission. The Journal of Nervous and Mental Disease [Internet]. 2012;200(1). WebsiteAbstract
Abstract: The present study aimed to explore exposure to stressful events during a psychiatric admission and the predictive power of peritraumatic distress and dissociation in the development of posttraumatic stress disorder (PTSD) symptoms after exposure to such events. Psychiatric inpatients (N = 239) were asked to report exposure to stressful events during their admission within 48 hours of being admitted. Individuals reporting at least one stressful event during admission (n = 70, 29%) were assessed for peritraumatic dissociation and distress in relation to this event and, 5 weeks later, were reassessed for PTSD symptoms. Eight participants (12.3%) scored above the cutoff for probable PTSD. Multiple regression analyses revealed that peritraumatic distress was a significant predictor of 5-week PTSD symptoms. Our findings suggest that individuals experiencing increased peritraumatic distress in relation to a stressful event experienced during a psychiatric admission might be at risk of PTSD symptoms and might benefit from increased attention.
Hinton DE, Kredlow MA, Bui E, Pollack MH, Hofmann SG. Treatment change of somatic symptoms and cultural syndromes among Cambodian refugees with PTSD. Depression and Anxiety [Internet]. 2012;29(2):148 - 155. WebsiteAbstract
Background There is only one previously published study of treatment change across initial pharmacological treatment for a minority or refugee group with posttraumatic stress disorder (PTSD). That study found that certain somatic symptoms among Southeast Asian populations did not improve across treatment. This article assesses in a culturally sensitive way symptom change through time of Cambodian patients presenting for pharmacotherapy treatment of PTSD. Methods Fifty-six Cambodian refugees with PTSD and no previous psychiatric treatment were assessed at baseline and then at 3 and 6 months after initiating pharmacotherapy. The measures included the PTSD Checklist; the Cambodian Somatic Symptom and Syndrome Inventory (SSI) to assess culturally salient somatic symptoms and cultural syndromes; and the Short Form-12 Health Survey to assess self-perceived functioning. Results Across treatment, large effect sizes were seen on all measures (Cohen's d = 1.1–1.4). The SF-12 change score was more highly correlated to the SSI change score (r = .82) than to the PTSD change score (r = .61). Significant change only occurred from baseline to 3 months. Conclusions Pharmacological treatment for traumatized Cambodian refugees with PTSD seems to lead to improvement not only in PTSD symptoms, but also in culturally salient somatic symptoms and cultural syndromes. Culturally sensitive assessment and treatment should ideally include the assessment of culturally salient somatic symptoms and cultural syndromes. Depression and Anxiety 0:1–8, 2011. © 2011 Wiley-Liss, Inc.
2011
Bui E, Rodgers R, Chabrol H, Birmes P, Schmitt L. Is Anakin Skywalker suffering from borderline personality disorder?. Psychiatry research [Internet]. 2011;185(1):299 - . WebsiteAbstract
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Neauport A, Rodgers RF, Simon NM, Birmes PJ, Scmitt L, Bui E. Effects of a psychiatric label on medical residents’ attitudes. International Journal of Social Psychiatry [Internet]. 2011. WebsiteAbstract
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Rieu J, Bui E, Rouch V, Faure K, Birmes P, Schmitt L. Efficacy of Ultrabrief Cognitive and Behavioural Therapy Performed by Psychiatric Residents on Depressed Inpatients. [Internet]. 2011;80(6):374 - 376. Website
Rodgers RF, Stritzke WGK, Bui E, Franko DL, Chabrol H. Evaluation of the French version of the orientation towards chocolate questionnaire: Chocolate-related guilt and ambivalence are associated with overweight and disordered eating. [Internet]. 2011;12(4):254 - 260. WebsiteAbstract
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Cailhol L, Bui E, Rouillon L, Bruno N, Lemoalle A, Faure K, Klein R, Lamy P, Guelfi J-D, Schmitt L. Indication différentielle des psychothérapies adaptées au trouble de la personnalité limite. Therapeutique [Internet]. 2011;37, Supplement 1:S77 - S82. WebsiteAbstract
RésuméLe trouble de personnalité limite (TPL) représente 10 % de l’activité psychiatrique ambulatoire. Le risque de suicide est important, ainsi que l’altération du fonctionnement psychosocial. L’objectif de notre revue de littérature est de déterminer l’efficacité des psychothérapies adaptées aux sujets présentant un TPL sur la sphère affective, comportementale, le fonctionnement interpersonnel et global ainsi que sur la personnalité. Pour cela, nous avons réalisé une revue de littérature de 1990 à 2008 sur Medline recoupant les mots clefs, « borderline personality disorder » et « psychotherapy » avec les limites « randomised control trial » ou « meta analysis ». Nous avons retenu 39 résumés, dont 17 (44 %) ont été sélectionnés, après application des critères d’exclusion (méthode non contrôlée, étude centrée sur un psychotrope, étude ne correspondant pas à notre objectif). Les psychothérapies apparaissent efficaces dans la prise en charge de plusieurs aspects touchant au TPL. La thérapie comportementale et dialectique possède le plus haut niveau de preuve, notamment concernant son action sur les comportements autoagressifs. La thérapie basée sur la mentalisation possède le plus large spectre d’action. La thérapie cognitive manualisée et la formation d’inspiration systémique à la prédiction émotionnelle et à la résolution de problème offrent la faisabilité la plus importante. En l’état actuel, il existe des différences d’indication probable en fonction des symptômes cibles et des ressources sanitaires disponibles. SummaryBackground Borderline personality disorder (BPD) accounts for 10% of outpatient psychiatric practice. The risk of suicide attempts is high and the psychosocial impairment significant. Different theoretical streams have suggested psychotherapeutical approaches for BPD. Objective to examine the efficacy of psychotherapy for BPD patients on affective symptoms, behavioural outcomes, interpersonal and social functioning, as well as BPD criteria. Methods We reviewed the medical literature from 1990 to 2008 on Medline by combining the following keywords “borderline personality disorder” and “psychotherapy” (inclusion criteria). We restricted the analysis to “randomised control trial” or “meta analysis”. Results Of the 39 abstracts that came out from the search, we selected 17 (44%) after applying the exclusion criteria. According to our review, different types of psychotherapies have shown some efficacy on reducing affective symptoms and BPD criteria, as well as improving behavioural outcomes and psychosocial functioning. Dialectical behavioural therapy presents the best-documented efficacy, notably on reducing self-mutilating and suicidal behaviours (five randomized controlled trials [RCT]). Mentalization based treatment seems to be efficient on the four types of outcomes, but has been the object of only one RCT. Finally, some evidence suggests that Manual Assisted Cognitive Treatment and Systems Training for Emotional Predictability and Problem Solving are the most cost-effective and easiest to be implemented. Conclusion According to our review, some evidence supports an efficiency of psychotherapies in the management of several features of BPD. It is likely that, depending on the target symptoms, one type of therapy might be more efficient than another. The acceptability of these long-term treatments is however unknown.
Bui E, Delrieu J, Wagner T, Rieu J, Véry E, Letamendia C, Payoux P, Schmitt L. Iodine-123 Fluoropropyl-Carbomethoxy-3-β-(4-Iodophenyltropane) Single-Photon Emission Computed Tomography Findings Before and After Electroconvulsive Therapy in Major Depressive Disorder With Parkinsonism. The Journal of ECT [Internet]. 2011;27(4). WebsiteAbstract
Background: To date, only a few cases of improvement of Parkinsonism in depressed patients treated with electroconvulsive therapy (ECT) have been reported. However, no functional imaging data are available to support this finding.Objective: To describe the first observation of increase in dopamine transporter uptake after ECT. Methods: Iodine-123 fluoropropyl-carbomethoxy-3-β-(4-iodophenyltropane) single-photon emission computed tomographic imaging was conducted in a 77-year-old depressed patient displaying symptoms of Parkinson disease (PD) before and after a series of 12 bilateral ECTs. Results: The patient displayed improvement in PD symptoms and increase in dopamine transporter uptake after ECT. Conclusions: Our observation suggests that the PD symptoms and decrease in striatal uptake appearing in the context of a depressive episode might warrant further attention, as they might be reversible.
Brunet A, Poundja J, Tremblay J, Bui É, Thomas É, Orr SP, Azzoug A, Birmes P, Pitman RK. Trauma Reactivation Under the Influence of Propranolol Decreases Posttraumatic Stress Symptoms and Disorder: 3 Open-Label Trials. Journal of Clinical Psychopharmacology [Internet]. 2011;31(4). Website
Mutabaruka J, Séjourné N, Bui E, Birmes P, Chabrol H. Traumatic Grief and Traumatic Stress in Survivors 12 Years after the Genocide in Rwanda. Stress and Health [Internet]. 2011:n/a - n/a. WebsiteAbstract
The relationship between exposure to traumatic events and traumatic grief and the role of mediating and moderating variables [peritraumatic distress, post traumatic stress disorder (PTSD) symptoms and symptoms of depression] were studied in survivors of the genocide of Batutsi in Rwanda in 1994. One hundred and two survivors (70 women, mean age 45 ± 7.53 years) participated in this retrospective study. All of them had lost a member of their family. The severity of traumatic exposure (Comprehensive Trauma Inventory), peritraumatic distress (Peritraumatic Distress Inventory), current PTSD symptoms (PTSD Checklist), depressive symptoms (Beck Depression Inventory) and traumatic grief symptoms (Inventory of Traumatic Grief) was evaluated. A hierarchical multiple regression analysis was then conducted to examine the relative contribution of each variable to the symptoms of traumatic grief. The severity of traumatic exposure was related to traumatic grief symptoms (B = 0.06, R = 0.6, R2 = 0.36 and ß = 0.6, t = 7.54, p = 0.00). The Baron and Kenny procedure (1986) (including three separate regressions), along with the Sobel test, was used to test mediation effects. Peritraumatic distress and PTSD symptoms may be mediating variables between traumatic exposure and traumatic grief. Traumatic grief is a complex but assessable entity, where previous distress and suffering result from both psychological trauma and the loss of a loved one. Copyright © 2011 John Wiley & Sons, Ltd.
Bui E, Brunet A, Olliac B, Very E, Allenou C, Raynaud J-P, Claudet I, Bourdet-Loubère S, Grandjean H, Schmitt L. Validation of the Peritraumatic Dissociative Experiences Questionnaire and Peritraumatic Distress Inventory in school-aged victims of road traffic accidents. [Internet]. 2011;26(2):108 - 111. WebsiteAbstract
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Bourredjem A, Pelissolo A, Rotge J-Y, Jaafari N, Machefaux S, Quentin S, Bui E, Bruno N, Pochon J-B, Polosan M. A video clinical global impression scale (CGI) in obsessive compulsive disorder. Psychiatry research [Internet]. 2011;186(1):117 - 122. WebsiteAbstract
The Clinical Global Impression scale (CGI) is frequently used in clinical research because of its face validity and ease of use but data on its reliability are scarce. Our goal was to estimate the reliability of the scale and compare reliability between face-to-face and video scoring. We analyzed 50 different video interviews recorded during 5 visits of a crossover trial to study the effect of subthalamic nucleus stimulation. Six specialized clinicians rated the CGI using these videos, providing 300 different ratings. The intraclass correlation was lower at inclusion (0.30 [0.13–0.50]) than at later visits (0.68 [0.61–0.80]). Reliability was not influenced by the patients' stimulation status. The mean of at least two independent evaluations of the video is needed to achieve an ICC greater than 0.8. The video CGI is a valid clinical outcome measure suitable for clinical trials (ClinicalTrials.gov number, NCT00169377).
2010
Alice in Wonderland Syndrome in Major Depressive Disorder. [Internet]. 2010;22(3):352.e16 - 352.e16. Website
Arbus C, Gardette V, Bui E, Cantet C, Andrieu S, Nourhashémi F, Schmitt L, Vellas B. Antidepressant use in Alzheimer's disease patients: results of the REAL.FR cohort. [Internet]. 2010;22(01):120 - 128 - M3 - 10.1017/S1041610209990780 . WebsiteAbstract
ABSTRACT ABSTRACTBackground: Psychotropic medication is widely prescribed in clinical practice for the management of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease (AD). However, there have been few pharmaco-epidemiological studies or studies conducted in a natural setting on the real use of antidepressants in AD. The aim of this survey was to assess the prevalence of antidepressant use in AD and to identify the clinical factors associated with antidepressant prescription.Methods: REAL.FR is a four-year, prospective, multi-center study. Baseline data including demographic characteristics, clinical variables and drug intake were obtained. Depressive symptoms were determined using the Neuropsychiatric Inventory (NPI).Results: A total of 686 AD patients were included. Antidepressant treatment was prescribed for 34.8% of patients. Clinically significant depressive symptoms (NPI ≥ 4) were observed in 20.5% of the total population. Although depressed subjects were significantly more likely to be treated with antidepressants than non-depressed subjects (p<0.0001), only 60% of depressed subjects overall were prescribed an antidepressant. In multivariate analysis, clinically significant depressive symptoms were associated with antidepressant prescription although this result was only observed in subjects without a previous history of depression.Conclusions: The available data on antidepressant efficacy in BPSD other than depression (in particular, agitation, aggression and, occasionally, psychotic symptoms) do not influence prescription choices. Depressive symptoms may be taken more seriously in the absence of a previous history of depression, leading to increased antidepressant prescription rates in individuals presenting with depression for the first time.
Bui E, Rodgers R, Cailhol L, Birmes P, Chabrol H, Schmitt L. Body Piercing and Psychopathology: A Review of the Literature. [Internet]. 2010;79(2):125 - 129. Website

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