The Loggia lab's main research questions focus on the neural mechanisms of pain in humans. We are particularly interested in the evaluation of neuroimaging metrics as potential biomarkers of clinical pain, and in the identification of brain alterations occurring in patients suffering from chronic pain conditions. Some of the lab's most recent work focuses of the exploration of the role of non-neural cells in the brain (glial cells) and their interplay with neural cells as a potential pathophysiological mechanism in patients with chronic pain. While neuroinflammation has been the subject of intense investigation in animal models, as of today it has been heavily understudied in humans. In the quest to achieve a deeper understanding of the brain mechanisms of human pain, we use a variety of psychophysical and brain imaging techniques, such as functional magnetic resonance imaging (fMRI), -including Blood Oxygen Level Dependent (BOLD) fMRI and Arterial Spin Labeling (ASL)-, as well as integrated Positron Emission Tomography / Magnetic Resonance (PET/MR) imaging.

Latest News

6/16/16 Welcome to our new intern, Hagen Puller! More

6/02/16 Welcome to our new research coordinators, Courtney Bergan and Ellie Kim! More

6/01/16 Marco presents at the NIH Pain Consortium Symposium! More

4/30/16 Our Brain study highlighted in keynote addresses by NIH director Francis Collins and NIDA Director Nora Volkow! More

4/19/16 Marco receives new R01 grant from the NINDS! More

3/29/16 Dan Albrecht's new review on in vivo imaging of human neuroinflammation released in ACS Chemical Neuroscience! More

3/01/16 Marco's Why-and-How talk on neuroanatomy is now on Youtube! More

2/5/16 Marco is the recipient of the 2016 IASP Ulf Lindblom Young Investigator Award for Clinical Science! More

1/12/16 Pain Research Forum recognizes our 2015 Brain paper as one of the top studies of the year 2015! More 

8/21/15 New Review on Chronic Headache in Collaboration with Wei-Ta Chen Has Been Accepted for Publication! More

8/17/15 "When you imagine an itch, does it make it so?" New Paper in Collaboration with Vitaly Napadow accepted for publication! More

7/3/15 New Publication Accepted in Brain Connectivity, in Collaboration with Colleagues at UPMC! More

6/16/15 Marco featured in the July issue of Popular Science! More 

5/14/15 Marco chairs a session on glia and pain at the 5th NeuPSIG Congress in Nice, France! More 

5/13/15 Our Brain 2015 paper is featured in the May issue of Anesthesiology (Science, Medicine and the Anesthesiologist)! More

4/13/15 Marco presents at the Harvard Catalyst Advanced Imaging in Clinical/Translational Neuroscience Research! More

4/9/15 Marco and colleagues' new paper, "The lateral prefrontal cortex mediates the hyperalgesic effects of negative cognitions in chronic pain patients," has been accepted for publication in the Journal of Pain! More 

2/13/15 Marco's Brain paper is featured in "il Venerdi' di Repubblica" (italian). Take a look here!

1/21/15 The Rheumatologist publishes a feature on Marco's fMRI research. Read it for a great introduction to the lab's work! 

1/15/2015 Our 2015 Brain paper is receiving press attention! Read the articles here!