<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Upadhyay, G. A.</style></author><author><style face="normal" font="default" size="100%">Choudhry, N. K.</style></author><author><style face="normal" font="default" size="100%">Auricchio, A.</style></author><author><style face="normal" font="default" size="100%">Ruskin, J.</style></author><author><style face="normal" font="default" size="100%">Singh, J. P.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cardiac resynchronization in patients with atrial fibrillation: a meta-analysis of prospective cohort studies</style></title><secondary-title><style face="normal" font="default" size="100%">J Am Coll Cardiol</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2008</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Oct 7</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=18926327</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">15</style></number><edition><style face="normal" font="default" size="100%">2008/10/18</style></edition><volume><style face="normal" font="default" size="100%">52</style></volume><pages><style face="normal" font="default" size="100%">1239-46</style></pages><isbn><style face="normal" font="default" size="100%">1558-3597 (Electronic)</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">OBJECTIVES: This study is a meta-analysis of prospective cohort studies comparing the impact of cardiac resynchronization therapy (CRT) for patients in atrial fibrillation (AF) and sinus rhythm (SR). BACKGROUND: Although close to one-third of advanced heart failure patients exhibit AF, the impact of CRT in this group remains unclear. METHODS: Prospective cohort studies comparing patients in normal SR and chronic AF treated with CRT were included. All studies reported death, New York Heart Association functional class, ejection fraction, 6-min walk test, and the Minnesota score or its equivalent as outcomes. Data sources included Ovid MEDLINE In-Process &amp; Other Non-Indexed Citations, the Cochrane Central Register of Controlled Trials, the Database of Abstracts of Reviews of Effects, and the American College of Physicians Journal Club. RESULTS: Of 2,487 reports identified, 5 studies following a total of 1,164 patients were included. Both AF and SR patients benefited significantly from CRT. Mortality was not significantly different at 1 year (relative risk ratio: 1.57, 95% confidence interval [CI]: 0.87 to 2.81). The New York Heart Association functional class improved similarly for both groups (-0.90 for SR patients, -0.84 for AF patients). SR patients showed greater relative improvement in the 6-min walk test (11.6 m greater, 95% CI: 10.4 to 12.8 m) and the Minnesota score (3.9 points less, 95% CI: 3.4 to 4.5 points) than AF patients. AF patients, however, achieved a small but statistically significant greater change in ejection fraction (0.39% greater change in ejection fraction, 95% CI: 0.22% to 0.55%). CONCLUSIONS: Patients in AF show significant improvement after CRT, with similar or improved ejection fraction as SR patients, but smaller benefits in regard to functional outcomes.</style></abstract><accession-num><style face="normal" font="default" size="100%">18926327</style></accession-num><notes><style face="normal" font="default" size="100%">Upadhyay, Gaurav AChoudhry, Niteesh KAuricchio, AngeloRuskin, JeremySingh, Jagmeet PUnited StatesJournal of the American College of CardiologyJ Am Coll Cardiol. 2008 Oct 7;52(15):1239-46.</style></notes><auth-address><style face="normal" font="default" size="100%">Department of Medicine and the Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.</style></auth-address></record></records></xml>