BioNEMS for Real Time Viral/Bacterial Pathogen Detection
Fast, sensitive and portable virus detection techniques are essential to prevent and control future epidemics and bioterrorism threats. We have recently demonstrated a label-free biosensor that can directly detect live viruses (such Ebola and Small Pox surrogates) from biological media at clinical concentrations with minimal sample preparation. This PCR free detection technique enables point of care diagnostics in resource poor settings in developing world and on-field conditions.
Yanik et al. “An Optofluidic-NanoPlasmonic Biosensor for Direct Detection of Live Viruses from Biological Media”,Nano Letters,10 (12), pp 4962–4969 (2010).
Artar & Yanik et al “Fabry-Perot Nanocavities in Multilayered Crystals for Enhanced Biosensing”, Appl. Phys. Lett, Vol. 95, No. 051105, (2009).
Electromagnetically Induced Transparency (EIT), a spectrally narrow optical transmission window accompanied with extreme dispersion, give rise to dramatically slow down photons and orders of magnitude enhanced optical non-linearities enabling manipulation of light at few photon levels. We have proposed and demonstrated a novel approach based on coupled meta-atoms consisting of meta-materials to construct a homogeneous and scalable medium supporting multispectral EIT-like effect (plasmon induced transparency) that can simultaneously enhance multicoloredphoton-photon interactions.
Non-Equilibrium Quantum Transport in Molecular/Nano-Electronic Devices
Non-equilibrium Green's function (NEGF) formalism has been shown to be a unified, extremely efficient and accurate way to understand quantum transport and design nanoscale devices from graphene films to quantum hall effect devices. Furthermore, it is not straightforward to include dissipative interactions other quantum transport approaches such as Landauer formalism. NEGF formalism provides a natural framework for describing quantum transport in the presence of incoherent and dissipative processes. In the past, I studied electron and spin-dependent electron transport in semiconductors, carbon nanotubes and magnetic tunneling junctions using NEGF formalism.
Yanik et al., “Coherent Transport in Single-Wall Nanotubes with Spin-Orbit Coupling”,IEEE Nanotechnology, Vol. 4, 89-91, (2004).
"Invited Paper" in IEEE Nanotechnology IV, August 16-19 (2004).
Single Molecule Vibrational Spectroscopy & Proteomics
Plasmonic nano-antennaswith their unique ability to focus light beyond the diffraction limit, are at the core of a myriad of new exciting opportunities. Using collective plasmonic excitations in nano-antenna arrays, we have demonstrated 100,000 fold signal enhancements in conformational signatures of proteins. We achieved record low zepto-mole detection limits corresponding to vibrational signatures from ~10 molecules per antenna opening the door to single molecule level absorption spectroscopy.
Adato* & Yanik* et al. “Ultrasensitive Vibrational Spectroscopy of Protein Monolayers with Plasmonic Nanoantenna Arrays”, Proc. Natl. Acad. Sci. , 106, 19227 (2009). (*co-first authors)
Adato & Yanik et al. “Radiative Engineering of Plasmon Lifetimes in Embedded Nanoantenna Arrays”, Optics Express, Vol 18, pp. 4526-4537 (2010). (*co-first authors)
“Pickin' up Good Vibrations, with Nanoantenna Arrays”, Biophotonics International, Jan, 2010.
Highlighted in The Journal of Future Medicine “Nanoantenna Analysis of Biomolecules could give New Lease of Life to Drug Design” , December, 2009.
“Ultra-Sensitive Vibrational Spectroscopy”, Spectroscopy Now. Jan 15, 2010.
“Identifying Molecules in Infrared Could Lead to New Medicines”, The Epoch Times, Nov 3, 2009.
“New technique for "Seeing" How Proteins Interact is a Potential Game Changer”, U.S.NEWS, Oct 28, 2009.
Highlighted in National Academy Of Sciences Timeline.
“Identifying Molecules in Infrared Could Lead to New Medicines”, National Science Foundation, Oct 26, 2009.
"Invited Paper" in Virtual Journal of Biological Physics Research, Volume 18, Issue 11 (2009).
"Invited Paper" in Virtual Journal of Nanoscale Science & Technology, Volume 20, Issue 22 (2009).
Interference Nanolithography & 3-D Wafer Scale Fabrication of Metamaterials
Recently, we invented a high-throughput Lift-off Free Evaporation (LIFE) Nano-Lithography with extremely uniform and precisely controlled nanofeatures over large areas, leading to record high-quality optical resonances and ultrasensitive biosensors. We experimentally demonstrated record-low detection limits that are one to two orders of magnitude better than any plasmonic and metamaterial biosensors in literature. Furthermore, we adopted this fabrication scheme for realization of 3-D meta-materials for slow light and enhanced light-matter interactions.
Yanik e al.,“Seeing Biomolecular Monolayers with Naked Eye through Plasmonic Fano Resonances”,Proc. Natl. Acad. Sci. (PNAS), Vol 108, pp. 11784-11789 (2011).
Chang, Huang & Yanik et al.,“Large-Scale Plasmonic Microarrays for Label-Free High-Throughput Screening”, Lab-on-a-Chip, 11, 3596-3602 (2011).
“Cover Paper” to Lab-on-a-Chip, Issue 21 (2011).
One of the Top 10 Most Downloaded Research Articles in September 2011.
Selected as HOT Paper by Royal Chemical Society, 19 Sep (2011).
Related Article: “Research Highlights” by Seila Selimovic and Ali Khademhosseini, Lab-on-a-Chip, 11, 3386-3388 (2011).
Highlighted in Nanotechnology Reviews 3 DOI: 10.1515/ntrev-2011-0008 (2012)
Featured in Institute of Physics (IOP) Nanotech News and Biomarker & Diagnostic Breakthroughs Aug 4, 2011.
"Invited Paper" in Virtual Journal of Biological Physics Research, Volume 22, Issue 3 (2011).
"Invited Paper" in Virtual Journal of Nanoscale Science & Technology, Volume 24, Issue 6 (2011).