@article {33346,
	title = {Regional and Hemispheric Asymmetries of Cerebral Hemodynamic and Oxygen Metabolism in Newborns},
	journal = {Cerebral Cortex},
	volume = {23},
	number = {2},
	year = {2012},
	pages = {339-348},
	abstract = {Understanding the evolution of regional and hemispheric asymmetries in the early stages of life is essential to the advancement of developmental neuroscience. By using 2 noninvasive optical methods, frequency-domain near-infrared spectroscopy and diffuse correlation spectroscopy, we measured cerebral hemoglobin oxygenation (SO2), blood volume (CBV), an index of cerebral blood flow (CBFi), and the metabolic rate of oxygen (CMRO2i) in the frontal, temporal, and parietal regions of 70 premature and term newborns. In concordance with results obtained using more invasive imaging modalities, we verified both hemodynamic (CBV, CBFi, and SO2) and metabolic (CMRO2i) parameters were greater in the temporal and parietal regions than in the frontal region and that these differences increased with age. In addition, we found that most parameters were significantly greater in the right hemisphere than in the left. Finally, in comparing age-matched males and females, we found that males had higher CBFi\&nbsp;in most cortical regions, higher CMRO2i\&nbsp;in the frontal region, and more prominent right{\textendash}left CBFi\&nbsp;asymmetry. These results reveal, for the first time, that we can detect regional and hemispheric asymmetries in newborns using noninvasive optical techniques. Such a bedside screening tool may facilitate early detection of abnormalities and delays in maturation of specific cortical areas.},
	url = {http://cercor.oxfordjournals.org/content/early/2012/02/10/cercor.bhs023},
	author = {Pei-Yi Lin and Nadege Roche-Labarbe and Mathieu Dehaes and Angela Fenoglio and P. Ellen Grant and Maria Angela Franceschini}
}
