Innovation, globalization, and digitalization are transforming every industry. This course focuses on creating new businesses, new markets, and effectiveness through innovation, entrepreneurship, and digital capabilities. Entire industries are threatened by disruptors like Uber, Airbnb and blockchain: outsiders with new, less expensive solutions for customers. Apple, Amazon, Skype, and digital currencies have created uncontested markets, delivered higher value, redefined channels, and secured competitive advantages. Blockchain is capable of transforming virtually every industry. Entrepreneurs and existing firms are compelled to create innovative environments, products, processes, services, and new business models. Incremental improvements are not enough. We examine successful strategies, business models, frameworks, funding options, barriers, and risks for introducing breakthrough products and services. Topics include business model innovation, design thinking, lean thinking, organizational learning, agility, blockchain, and fundraising.