Our research examines structural and functional changes in the brain with aging and age-associated neurodegenerative disease. A primary focus of this work is to determine how the common decline in vascular health with advancing age contributes to neurodegenerative changes, cognitive attenuation and the development of Alzheimer’s disease and other dementias. We utilize structural and functional neuroimaging technology as a primary tool to measure subtle alterations in tissue integrity and physiology and how those changes relate to measures of cognitive function and systemic physiology. Through these studies, we hope to advance procedures for the clinical utilization of imaging technology in the diagnosis, characterization and tracking of neurodegenerative disease as well as towards advancing understanding of the pathological mechanisms that cause dementia.
- Hear our Director, Dr. Reisa Sperling, talk about the future of Alzheimer's disease clinical trials on @WBUR: t.co/Vx9i3Lf0ks
- NI: False positive rates in surface-based anatomical analysis t.co/JvyRfM0ymF
Factors influencing accuracy of cortical thickness in the diagnosis of Alzheimer's disease t.co/fDFQ6qriKB #Alzheimers @MGHMartinos t.co/liSCGaTjeW
David Salat recapping his 2004 paper on cortical thinning in aging at the #FreeSurfer 20 year symposium. t.co/tNuf3l92lx
Neuroimaging of deployment-associated traumatic brain injury (TBI) with a focus on mild TBI (mTBI) since 2009. t.co/xGMtMM9V34 t.co/WoTL6LXw3w