Massachusetts General Hospital and Harvard Medical School
The Bastepe Lab investigates endocrine diseases that involve mineral ion metabolism and skeletal health. We are primarily interested in diseases caused by disrupted G protein signaling and GPCR actions. Using molecular genetics and a wide range of in vitro and in vivo technologies, our studies currently focus on the GNAS complex locus, an imprinted gene giving rise to the alpha-subunit of the stimulatory G protein (Gsα) and multiple other monoallelically expressed transcripts and proteins, such as XLαs. Our laboratory also investigates the role of Gq/11 and protein kinase C signaling in the hormonal regulation of bone and mineral metabolism, particularly regarding the actions of FGF23 and PTH.