Karel is a research associate at Harvard University, working with Prof. Bill Hanage in the Center for Communicable Disease Dynamics at Harvard Chan School and Prof. Michael Baym in the Department of Biomedical Informatics at Harvard Medical School. His research focuses on methods for rapid antibiotic resistance detection from point-of-care sequencing data obtained by mobile sequencing technologies.

Karel is the lead developer of RASE, ProPhyleOcoco, RNFtools, SAMsiftProphAsmDyMas, and Disty McMatrixFace. He was also involved in the development of Blind Friendly MapsProPhex, Seed-KrakenSeed-Jellyfish, and NanoSim-H.

Prior to joining Harvard, Karel received his Ph.D. in computer science at Université Paris-Est and a master degree in mathematical computer science at the Czech Technical University in Prague.