@article {150496, title = {Neurobiological Mechanisms for Impulsive-Aggression: The Role of MAOA.}, journal = {Curr Top Behav Neurosci}, year = {2014}, month = {2014 Jan 28}, abstract = {Aggression may be present across a large part of the spectrum of psychopathology, and underlies costly criminal antisocial behaviors. Human aggression is a complex and underspecified construct, confounding scientific discovery. Nevertheless, some biologically tractable subtypes are apparent, and one in particular-impulsive (reactive) aggression-appears to account for many facets of aggression-related dysfunction in psychiatric illness. Impulsive-aggression is significantly heritable, suggesting genetic transmission. However, the specific neurobiological mechanisms that mediate genetic risk for impulsive-aggression remain unclear. Here, we review extant data on the genetics and neurobiology of individual differences in impulsive-aggression, with particular attention to the role of genetic variation in Monoamine Oxidase A (MAOA) and its impact on serotonergic signaling within corticolimbic circuitry.}, issn = {1866-3370}, doi = {10.1007/7854_2013_272}, author = {Dorfman, Hayley M and Andreas Meyer-Lindenberg and Joshua W. Buckholtz} }