We investigated the effects substance-related cardiac arrests (SRCA) in patients who failed to regain consciousness after resuscitation on severe cerebral edema development, a neuroimaging intermediate endpoint for neurologic injury. Patients for whose cardiac arrests could be attributed to substance-use were more likely to develop severe cerebral edema compared to patients whose cardiac arrests were not due to subtance-use. SRCA patients had higher proportion of brain deaths compared to non-SRCA patients. However, there were no statistically significant differences in...