Liquid-liquid phase separation in biology


Anthony A. Hyman, Christoph A. Weber, and Frank Jülicher. 2014. “Liquid-liquid phase separation in biology.” Annual review of cell and developmental biology, 30, Pp. 39–58.


Cells organize many of their biochemical reactions in non-membrane compartments. Recent evidence has shown that many of these compartments are liquids that form by phase separation from the cytoplasm. Here we discuss the basic physical concepts necessary to understand the consequences of liquid-like states for biological functions.