Who is Clarence?
Clarence obtained his MSc and DPhil from the University of Oxford, England in the labs of Professor Udo Oppermann and Professor Alison Noble. His postdoctoral studies was under Dr. Susanne Muller-Knapp at the Structural Genomics Consortium and Target Discovery Institute where they pioneered cell-based assays for validating novel epigenetic targets and identifying over 20 small molecule chemical probes. During that time, he simultaneously served as Microscopy Manager for the Botnar Research Center. He studied Biomedical Engineering and prior to that, Mechatronics Engineering. Now, Clarence is the Platform Manager for Microscopy and Image Analysis at the Laboratory of Systems Pharmacology (LSP) under Professor Peter Sorger, as well as a research associate at the Image and Data Analysis Core (IDAC) under Dr. Hunter Elliott, and regularly works with the Nikon Imaging Center (NIC) under Dr. Jennifer Waters at Harvard Medical School (HMS).
SB Hatch*, C Yapp*, RC Montenegro et al., 2017, Assessing histone demethylase inhibitors in cells: lessons learned, Epigenetics and Chromatin (preprint)
A Kawamura, M Munzel, T Kojima, C Yapp et al., 2017, Highly Selective inhibition of histone demethylases by de novo macrocyclic peptides, Nature Communications (preprint)
C Yapp, U Oppermann, A Price et al., 2016, H3K27me3 demethylases regulate in vitro chondrogenesis and chondrocyte activity in osteoarthritis, Arthritis Res. Ther., 18(1):158
C Yapp, C Rogers, Pavel Savitsky et al., 2016, Frapid: achieving full automation of FRAP for chemical probe validation, Biomed. Opt. Express, 7(2):422-441
MK Kuzniarska, C Yapp, PA Hulley, 2016, Using fluorescence recovery after photobleaching to study gap junctional communication in vitro, Gap Junction Protocols, 1437:171-179
SG Dakin, FM Estrada, C Yapp et al., 2016, Inflammation activation and resolution in human tendon disease, Sci. Transl. Med., 7(311):173
CL Sutherell, C Tallant, O Monteiro, C Yapp et al., 2016, Identificaton and development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex, J. Med. Chem.
TM Grant, C Yapp et al., 2015, The Mechanical, structural, and compositional changes of tendon exposed to elastase, Ann. Biomed. Eng.
CC Thinnes, A Tumber, C Yapp et al., 2015, Betti Reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases, Chem. Commun.
M Philpott, CM Rogers, C Yapp, et al., 2014, Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching, Epigenetics & Chromatin
MK Kuzniarska, C Yapp et al., 2014, Functional assessment of gap junctions in monolayer and three-dimensional cultures of human tendon cells using fluorescence recovery after photobleaching. J. Biomed. Opt.
RJ Hopkinson*, A Tumber*, C Yapp* et al., 2013, 5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation. Chemical Science
I Adekanmbi, NZ Baboldashti, C Yapp et al. 2013, A novel in vitro loading system for high frequency loading of cultured tendon fascicles. Med Eng Phys.
U Tirlapur & C Yapp, 2011, Near Infrared Three-Dimensional Nonlinear Optical Monitoring of Stem Cell Differentiation. Optical Fluorescence Microscopy
C Yapp & ASK Bin, 2008, Teaching Image Processing: A Two Step Process. Computer Applications in Engineering Education. 16(3):211-222
LB Leong & C Yapp, 2008, Dissipative Relativistic Standard Map. Chaos, Solitons & Fractals. 37(5): 1300-1304