• actin and osteoclast


    ...are the cells that clear away bone and have a characteristic actin ring and multiple nuclei (sometimes as many as 30!)

  • Still good...

    A cell optoporated with propidium iodide (a DNA intercalator, shown in red) still managers to divide

  • BRD4

    It's a pile of FRAP!

    Fluorescence Recovery After Photobleaching (FRAP) can reveal how well a protein is bound to its target in presence of a drug

  • collagen

    Comparing extracellular matrix in disease and healthy tissue

    Collagen and elastin produce a unique second harmonic signal and two photon excitation fluorescence respectively

  • cell 7

    Dead or alive

    A temporary hole can be made in the cell membrane to allow proteins that normally would not enter a living cell

Highlighted Publications

Z Inde, C Yapp et al., 2020, Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 disease severity, Biorxiv, doi: https://doi.org/10.1101/2020.09.13.276923

A Farkkila....C Yapp  et al., 2020, Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer, Nat. Comm. 11, 1459

G Gaglia, R Rashid, C Yapp et al., 2020, HSF1 phase transition mediates stress adaptation and cell fate decisions, Nat. Cel. Biol., 22, 151-158

ML Onozato*, C Yapp*,(* contributed equally) et al., 2019, Highly Multiplexed Fluorescence in Situ Hybridization for in Situ Genomics, J Molecular Diagnostics, 21:3, 390–407

S Saka,...C Yapp, et al., ,2019, Highly multiplexed in situ protein imaging with signal amplification by Immuno-SABER, Nat. Biotech, 37(9), 1080

JR Lin, ...C Yapp, et al., 2018, Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes, Elife, 11,7: e31657

SB Hatch*, C Yapp*, (* contributed equally) et al., 2017, Assessing histone demethylase inhibitors in cells: lessons learned, Epigenetics and Chromatin, 10:9

C Yapp, U Oppermann, A Price et al., 2016, H3K27me3 demethylases regulate in vitro chondrogenesis and chondrocyte activity in osteoarthritis, Arthritis Res. Ther., 18(1):158

C Yapp, C Rogers, Pavel Savitsky et al., 2016, Frapid: achieving full automation of FRAP for chemical probe validation, Biomed. Opt. Express, 7(2):422-441

M Philpott, CM Rogers, C Yapp, et al., 2014, Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching, Epigenetics & Chromatin

RJ Hopkinson*, A Tumber*, C Yapp* (* contributed equally) et al., 2013, 5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation. Chemical Science