This course provides a critical overview of conceptual approaches and empirical evidence for interventions that take a social determinants approach to reduce socioeconomic and racial/ethnic disparities in health status. The focus is on the extent to which policies and interventions on the social determinants of health can both improve health and reduce disparities. It considers interventions within the healthcare system, but emphasis is given to population-based interventions on the social determinants of health in multiple other societal sectors.