Publications

    J. T. Heaton, et al., “Aerodynamically driven phonation of individual vocal folds under general anesthesia in canines,” The Laryngoscope, In Press. Publisher's VersionAbstract

    Objectives/Hypothesis

    We previously developed an instrument called the Aerodynamic Vocal Fold Driver (AVFD) for intraoperative magnified assessment of vocal fold (VF) vibration during microlaryngoscopy under general anesthesia. Excised larynx testing showed that the AVFD could provide useful information about the vibratory characteristics of each VF independently. The present investigation expands those findings by testing new iterations of the AVFD during microlaryngoscopy in the canine model.

    Study Design

    Animal model.

    Methods

    The AVFD is a handheld instrument that is positioned to contact the phonatory mucosa of either VF during microlaryngoscopy. Airflow delivered through the AVFD shaft to the subglottis drives the VF into phonation‐like vibration, which enables magnified observation of mucosal‐wave function with stroboscopy or high‐speed video. AVFD‐driven phonation was tested intraoperatively (n = 26 VFs) using either the original instrument design or smaller and larger versions three‐dimensionally printed from a medical grade polymer. A high‐fidelity pressure sensor embedded within the AVFD measured VF contact pressure. Characteristics of individual VF phonation were compared with typical two‐fold phonation and compared for VFs scarred by electrocautery (n = 4) versus controls (n = 22).

    Results

    Phonation was successful in all 26 VFs, even when scar prevented conventional bilateral phonation. The 15‐mm‐wide AVFD fits best within the anteroposterior dimension of the musculo‐membranous VF, and VF contact pressure correlated with acoustic output, driving pressures, and visible modes of vibration.

    Conclusions

    The AVFD can reveal magnified vibratory characteristics of individual VFs during microlaryngoscopy (e.g., without needing patient participation), potentially providing information that is not apparent or available during conventional awake phonation, which might facilitate phonosurgical decision making.

    Level of Evidence

    NA

    H. Ghasemzadeh, D. D. Deliyski, D. S. Ford, J. B. Kobler, R. E. Hillman, and D. D. Mehta, “Method for vertical calibration of laser-projection transnasal fiberoptic high-speed videoendoscopy,” Journal of Voice, In Press. Publisher's VersionAbstract
    The ability to provide absolute calibrated measurement of the laryngeal structures during phonation is of paramount importance to voice science and clinical practice. Calibrated three-dimensional measurement could provide essential information for modeling purposes, for studying the developmental aspects of vocal fold vibration, for refining functional voice assessment and treatment outcomes evaluation, and for more accurate staging and grading of laryngeal disease. Recently, a laser-calibrated transnasal fiberoptic endoscope compatible with high-speed videoendoscopy (HSV) and capable of providing three-dimensional measurements was developed. The optical principle employed is to project a grid of 7 × 7 green laser points across the field of view (FOV) at an angle relative to the imaging axis, such that (after calibration) the position of each laser point within the FOV encodes the vertical distance from the tip of the endoscope to the laryngeal tissues. The purpose of this study was to develop a precise method for vertical calibration of the endoscope. Investigating the position of the laser points showed that, besides the vertical distance, they also depend on the parameters of the lens coupler, including the FOV position within the image frame and the rotation angle of the endoscope. The presented automatic calibration method was developed to compensate for the effect of these parameters. Statistical image processing and pattern recognition were used to detect the FOV, the center of FOV, and the fiducial marker. This step normalizes the HSV frames to a standard coordinate system and removes the dependence of the laser-point positions on the parameters of the lens coupler. Then, using a statistical learning technique, a calibration protocol was developed to model the trajectories of all laser points as the working distance was varied. Finally, a set of experiments was conducted to measure the accuracy and reliability of every step of the procedure. The system was able to measure absolute vertical distance with mean percent error in the range of 1.7% to 4.7%, depending on the working distance.
    D. D. Mehta, et al., “Toward development of a vocal fold contact pressure probe: Bench-top validation of a dual-sensor probe using excised human larynx models,” Applied Sciences, vol. 9, no. 20, pp. 4360, 2019. Publisher's VersionAbstract
    A critical element in understanding voice production mechanisms is the characterization of vocal fold collision, which is widely considered a primary etiological factor in the development of common phonotraumatic lesions such as nodules and polyps. This paper describes the development of a transoral, dual-sensor intraglottal/subglottal pressure probe for the simultaneous measurement of vocal fold collision and subglottal pressures during phonation using two miniature sensors positioned 7.6 mm apart at the distal end of a rigid cannula. Proof-of-concept testing was performed using excised whole-mount and hemilarynx human tissue aerodynamically driven into self-sustained oscillation, with systematic variation of the superior–inferior positioning of the vocal fold collision sensor. In the hemilarynx experiment, signals from the pressure sensors were synchronized with an acoustic microphone, a tracheal-surface accelerometer, and two high-speed video cameras recording at 4000 frames per second for top–down and en face imaging of the superior and medial vocal fold surfaces, respectively. As expected, the intraglottal pressure signal exhibited an impulse-like peak when vocal fold contact occurred, followed by a broader peak associated with intraglottal pressure build-up during the de-contacting phase. As subglottal pressure was increased, the peak amplitude of the collision pressure increased and typically reached a value below that of the average subglottal pressure. Results provide important baseline vocal fold collision pressure data with which computational models of voice production can be developed and in vivo measurements can be referenced.
    M. Motie-Shirazi, et al., “Toward development of a vocal fold contact pressure probe: Sensor characterization and validation using synthetic vocal fold models,” Applied Sciences, vol. 9, no. 15, pp. 3002, 2019. Publisher's VersionAbstract
    Excessive vocal fold collision pressures during phonation are considered to play a primary role in the formation of benign vocal fold lesions, such as nodules. The ability to accurately and reliably acquire intraglottal pressure has the potential to provide unique insights into the pathophysiology of phonotrauma. Difficulties arise, however, in directly measuring vocal fold contact pressures due to physical intrusion from the sensor that may disrupt the contact mechanics, as well as difficulty in determining probe/sensor position relative to the contact location. These issues are quantified and addressed through the implementation of a novel approach for identifying the timing and location of vocal fold contact, and measuring intraglottal and vocal fold contact pressures via a pressure probe embedded in the wall of a hemi-laryngeal flow facility. The accuracy and sensitivity of the pressure measurements are validated against ground truth values. Application to in vivo approaches are assessed by acquiring intraglottal and VF contact pressures using a synthetic, self-oscillating vocal fold model in a hemi-laryngeal configuration, where the sensitivity of the measured intraglottal and vocal fold contact pressure relative to the sensor position is explored.
    M. E. Powell, D. D. Deliyski, R. E. Hillman, S. M. Zeitels, J. A. Burns, and D. D. Mehta, “Comparison of videostroboscopy to stroboscopy derived from high-speed videoendoscopy for evaluating patients with vocal fold mass lesions,” American Journal of Speech-Language Pathology, vol. 25, pp. 576-589, 2016. Publisher's VersionAbstract

    indirect physiological signal to predict the phase of the vocal fold vibratory cycle for sampling. Simulated stroboscopy (SS) extracts the phase of the glottal cycle directly from the changing glottal area in the high-speed videoendoscopy (HSV) image sequence. The purpose of this study is to determine the reliability of SS relative to VS for clinical assessment of vocal fold vibratory function in patients with mass lesions.

    Methods VS and SS recordings were obtained from 28 patients with vocal fold mass lesions before and after phonomicrosurgery and 17 controls who were vocally healthy. Two clinicians rated clinically relevant vocal fold vibratory features using both imaging techniques, indicated their internal level of confidence in the accuracy of their ratings, and provided reasons for low or no confidence.

    Results SS had fewer asynchronous image sequences than VS. Vibratory outcomes were able to be computed for more patients using SS. In addition, raters demonstrated better interrater reliability and reported equal or higher levels of confidence using SS than VS.

    Conclusion Stroboscopic techniques on the basis of extracting the phase directly from the HSV image sequence are more reliable than acoustic-based VS. Findings suggest that SS derived from high-speed videoendoscopy is a promising improvement over current VS systems.

    D. D. Deliyski, R. E. Hillman, and D. D. Mehta, “Laryngeal high-speed videoendoscopy: Rationale and recommendation for accurate and consistent terminology,” Journal of Speech, Language, and Hearing Research, vol. 58, no. 5, pp. 1488-1492, 2015. Publisher's VersionAbstract

    Abstract Purpose: The authors discuss the rationale behind the term laryngeal high-speed videoendoscopy to describe the application of high-speed endoscopic imaging techniques to the visualization of vocal fold vibration. Method: Commentary on the advantages of using accurate and consistent terminology in the field of voice research is provided. Specific justification is described for each component of the term high-speed videoendoscopy, which is compared and contrasted with alternative terminologies in the literature. Results: In addition to the ubiquitous high-speed descriptor, the term endoscopy is necessary to specify the appropriate imaging technology and distinguish among modalities such as ultrasound, magnetic resonance imaging, and nonendoscopic optical imaging. Furthermore, the term video critically indicates the electronic recording of a sequence of optical still images representing scenes in motion, in contrast to strobed images using high-speed photography and non-optical high-speed magnetic resonance imaging. High-speed videoendoscopy thus concisely describes the technology and can be appended by the desired anatomical nomenclature such as laryngeal. Conclusions: Laryngeal high-speed videoendoscopy strikes a balance between conciseness and specificity when referring to the typical high-speed imaging method performed on human participants. Guidance for the creation of future terminology provides clarity and context for current and future experiments and the dissemination of results among researchers.

    G. Maguluri, E. Chang, N. Iftimia, D. Mehta, and J. Kobler, “Dynamic vocal fold imaging by integrating optical coherence tomography with laryngeal high-speed video endoscopy,” Proceedings of the Conference on Lasers and Electro-Optics (CLEO), pp. 1-2, 2015.Abstract

    We demonstrate three-dimensional vocal fold imaging during phonation by integrating optical coherence tomography with high-speed videoendoscopy. Results from ex vivo larynx experiments yield reconstructed vocal fold surface contours for ten phases of periodic motion.

    D. D. Mehta and R. E. Hillman, “The evolution of methods for imaging vocal fold phonatory function,” Perspectives on Speech Science and Orofacial Disorders, vol. 22, no. 1, pp. 5-13, 2012. Publisher's VersionAbstract

    In this article, we provide a brief summary of the major technological advances that led to current methods for imaging vocal fold vibration during phonation including the development of indirect laryngoscopy, imaging of rapid motion, fiber optics, and digital image capture. We also provide a brief overview of new emerging technologies that could be used in the future for voice research and clinical voice assessment, including advances in laryngeal high-speed videoendoscopy, depth-kymography, and dynamic optical coherence tomography.

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