High-Speed Video

In Press
D. D. Deliyski, et al., “Laser-calibrated system for transnasal fiberoptic laryngeal high-speed videoendoscopy,” Journal of Voice, In Press.
H. Ghasemzadeh, D. D. Deliyski, D. S. Ford, J. B. Kobler, R. E. Hillman, and D. D. Mehta, “Method for vertical calibration of laser-projection transnasal fiberoptic high-speed videoendoscopy,” Journal of Voice, In Press. Publisher's VersionAbstract
The ability to provide absolute calibrated measurement of the laryngeal structures during phonation is of paramount importance to voice science and clinical practice. Calibrated three-dimensional measurement could provide essential information for modeling purposes, for studying the developmental aspects of vocal fold vibration, for refining functional voice assessment and treatment outcomes evaluation, and for more accurate staging and grading of laryngeal disease. Recently, a laser-calibrated transnasal fiberoptic endoscope compatible with high-speed videoendoscopy (HSV) and capable of providing three-dimensional measurements was developed. The optical principle employed is to project a grid of 7 × 7 green laser points across the field of view (FOV) at an angle relative to the imaging axis, such that (after calibration) the position of each laser point within the FOV encodes the vertical distance from the tip of the endoscope to the laryngeal tissues. The purpose of this study was to develop a precise method for vertical calibration of the endoscope. Investigating the position of the laser points showed that, besides the vertical distance, they also depend on the parameters of the lens coupler, including the FOV position within the image frame and the rotation angle of the endoscope. The presented automatic calibration method was developed to compensate for the effect of these parameters. Statistical image processing and pattern recognition were used to detect the FOV, the center of FOV, and the fiducial marker. This step normalizes the HSV frames to a standard coordinate system and removes the dependence of the laser-point positions on the parameters of the lens coupler. Then, using a statistical learning technique, a calibration protocol was developed to model the trajectories of all laser points as the working distance was varied. Finally, a set of experiments was conducted to measure the accuracy and reliability of every step of the procedure. The system was able to measure absolute vertical distance with mean percent error in the range of 1.7% to 4.7%, depending on the working distance.
M. E. Powell, et al., “Efficacy of videostroboscopy and high-speed videoendoscopy to obtain functional outcomes from perioperative ratings in patients with mass lesions,” Journal of Voice, In Press. Publisher's Version
2019
M. Motie-Shirazi, et al., “Toward development of a vocal fold contact pressure probe: Sensor characterization and validation using synthetic vocal fold models,” Applied Sciences, vol. 9, no. 15, pp. 3002, 2019. Publisher's VersionAbstract
Excessive vocal fold collision pressures during phonation are considered to play a primary role in the formation of benign vocal fold lesions, such as nodules. The ability to accurately and reliably acquire intraglottal pressure has the potential to provide unique insights into the pathophysiology of phonotrauma. Difficulties arise, however, in directly measuring vocal fold contact pressures due to physical intrusion from the sensor that may disrupt the contact mechanics, as well as difficulty in determining probe/sensor position relative to the contact location. These issues are quantified and addressed through the implementation of a novel approach for identifying the timing and location of vocal fold contact, and measuring intraglottal and vocal fold contact pressures via a pressure probe embedded in the wall of a hemi-laryngeal flow facility. The accuracy and sensitivity of the pressure measurements are validated against ground truth values. Application to in vivo approaches are assessed by acquiring intraglottal and VF contact pressures using a synthetic, self-oscillating vocal fold model in a hemi-laryngeal configuration, where the sensitivity of the measured intraglottal and vocal fold contact pressure relative to the sensor position is explored.
Paper
2016
M. E. Powell, D. D. Deliyski, R. E. Hillman, S. M. Zeitels, J. A. Burns, and D. D. Mehta, “Comparison of videostroboscopy to stroboscopy derived from high-speed videoendoscopy for evaluating patients with vocal fold mass lesions,” American Journal of Speech-Language Pathology, vol. 25, pp. 576-589, 2016. Publisher's VersionAbstract

indirect physiological signal to predict the phase of the vocal fold vibratory cycle for sampling. Simulated stroboscopy (SS) extracts the phase of the glottal cycle directly from the changing glottal area in the high-speed videoendoscopy (HSV) image sequence. The purpose of this study is to determine the reliability of SS relative to VS for clinical assessment of vocal fold vibratory function in patients with mass lesions.

Methods VS and SS recordings were obtained from 28 patients with vocal fold mass lesions before and after phonomicrosurgery and 17 controls who were vocally healthy. Two clinicians rated clinically relevant vocal fold vibratory features using both imaging techniques, indicated their internal level of confidence in the accuracy of their ratings, and provided reasons for low or no confidence.

Results SS had fewer asynchronous image sequences than VS. Vibratory outcomes were able to be computed for more patients using SS. In addition, raters demonstrated better interrater reliability and reported equal or higher levels of confidence using SS than VS.

Conclusion Stroboscopic techniques on the basis of extracting the phase directly from the HSV image sequence are more reliable than acoustic-based VS. Findings suggest that SS derived from high-speed videoendoscopy is a promising improvement over current VS systems.

C. E. Stepp, M. Zañartu, D. D. Mehta, and R. E. Hillman, “Hyperfunctional voice disorders: Current results, clinical implications, and future directions of a multidisciplinary research program,” Proceedings of the Annual Convention of the American Speech-Language-Hearing Association, 2016.
N. Iftimia, G. Maguluri, E. Chang, J. Park, J. Kobler, and D. Mehta, “Dynamic vocal fold imaging with combined optical coherence tomography/high-speed video endoscopy,” Proceedings of the 10th International Conference on Voice Physiology and Biomechanics, pp. 1-2, 2016. Paper
2015
G. Maguluri, E. Chang, N. Iftimia, D. Mehta, and J. Kobler, “Dynamic vocal fold imaging by integrating optical coherence tomography with laryngeal high-speed video endoscopy,” Proceedings of the Conference on Lasers and Electro-Optics (CLEO), pp. 1-2, 2015.Abstract

We demonstrate three-dimensional vocal fold imaging during phonation by integrating optical coherence tomography with high-speed videoendoscopy. Results from ex vivo larynx experiments yield reconstructed vocal fold surface contours for ten phases of periodic motion.

Paper
D. D. Mehta, D. D. Deliyski, S. M. Zeitels, M. Zañartu, and R. E. Hillman, “Integration of transnasal fiberoptic high-speed videoendoscopy with time-synchronized recordings of vocal function”, K. Izdebski, Y. Yan, R. R. Ward, B. J. F. Wong, and R. M. Cruz, Ed. San Francisco: Pacific Voice & Speech Foundation, 2015, pp. 105-114. Publisher's Version
D. D. Deliyski, R. E. Hillman, and D. D. Mehta, “Laryngeal high-speed videoendoscopy: Rationale and recommendation for accurate and consistent terminology,” Journal of Speech, Language, and Hearing Research, vol. 58, no. 5, pp. 1488-1492, 2015. Publisher's VersionAbstract

Abstract Purpose: The authors discuss the rationale behind the term laryngeal high-speed videoendoscopy to describe the application of high-speed endoscopic imaging techniques to the visualization of vocal fold vibration. Method: Commentary on the advantages of using accurate and consistent terminology in the field of voice research is provided. Specific justification is described for each component of the term high-speed videoendoscopy, which is compared and contrasted with alternative terminologies in the literature. Results: In addition to the ubiquitous high-speed descriptor, the term endoscopy is necessary to specify the appropriate imaging technology and distinguish among modalities such as ultrasound, magnetic resonance imaging, and nonendoscopic optical imaging. Furthermore, the term video critically indicates the electronic recording of a sequence of optical still images representing scenes in motion, in contrast to strobed images using high-speed photography and non-optical high-speed magnetic resonance imaging. High-speed videoendoscopy thus concisely describes the technology and can be appended by the desired anatomical nomenclature such as laryngeal. Conclusions: Laryngeal high-speed videoendoscopy strikes a balance between conciseness and specificity when referring to the typical high-speed imaging method performed on human participants. Guidance for the creation of future terminology provides clarity and context for current and future experiments and the dissemination of results among researchers.

Paper
G. Luegmair, D. D. Mehta, J. B. Kobler, and M. Döllinger, “Three-dimensional optical reconstruction of vocal fold kinematics using high-speed video with a laser projection system,” IEEE Transactions on Medical Imaging, vol. 34, no. 12, pp. 2572-2582, 2015. Publisher's Version Paper
2014
M. L. Cooke, D. D. Mehta, and R. E. Hillman, “Relationships between the Cepstral-Spectral Index of Dysphonia and vocal fold vibratory function during phonation,” Proceedings of the 43rd Annual Symposium of the Voice Foundation: Care of the Professional Voice, 2014. Poster
2013
M. Zañartu, J. C. Ho, D. D. Mehta, R. E. Hillman, and G. R. Wodicka, “Acoustic coupling during incomplete glottal closure and its effect on the inverse filtering of oral airflow,” Proceedings of Meetings on Acoustics, vol. 19, pp. 060241-7, 2013. Paper
D. D. Mehta, et al., “High-speed videomicroscopy and acoustic analysis of ex vivo vocal fold vibratory asymmetry,” Proceedings of the 10th International Conference on Advances in Quantitative Laryngology, Voice and Speech Research, 2013. Paper
2012
D. D. Mehta and R. E. Hillman, “The evolution of methods for imaging vocal fold phonatory function,” Perspectives on Speech Science and Orofacial Disorders, vol. 22, no. 1, pp. 5-13, 2012. Publisher's VersionAbstract

In this article, we provide a brief summary of the major technological advances that led to current methods for imaging vocal fold vibration during phonation including the development of indirect laryngoscopy, imaging of rapid motion, fiber optics, and digital image capture. We also provide a brief overview of new emerging technologies that could be used in the future for voice research and clinical voice assessment, including advances in laryngeal high-speed videoendoscopy, depth-kymography, and dynamic optical coherence tomography.

Paper
D. D. Mehta, S. M. Zeitels, J. A. Burns, A. D. Friedman, D. D. Deliyski, and R. E. Hillman, “High-speed videoendoscopic analysis of relationships between cepstral-based acoustic measures and voice production mechanisms in patients undergoing phonomicrosurgery,” Annals of Otology, Rhinology, and Laryngology, vol. 121, pp. 341-347, 2012. Paper
2011
S. S. Karajanagi, et al., “Assessment of canine vocal fold function after injection of a new biomaterial designed to treat phonatory mucosal scarring,” Annals of Otology, Rhinology, and Laryngology, vol. 120, no. 3, pp. 175-184, 2011. Publisher's Version Paper
D. D. Mehta, D. D. Deliyski, T. F. Quatieri, and R. E. Hillman, “Automated measurement of vocal fold vibratory asymmetry from high-speed videoendoscopy recordings,” Journal of Speech, Language, and Hearing Research, vol. 54, no. 1, pp. 47-54, 2011. Publisher's VersionAbstract

Purpose: In prior work, a manually derived measure of vocal fold vibratory phase asymmetry correlated to varying degrees with visual judgments made from laryngeal high-speed videoendoscopy (HSV) recordings. This investigation extended this work by establishing an automated HSV-based framework to quantify 3 categories of vocal fold vibratory asymmetry. Method: HSV-based analysis provided for cycle-to-cycle estimates of left-right phase asymmetry, left-right amplitude asymmetry, and axis shift during glottal closure for 52 speakers with no vocal pathology producing comfortable and pressed phonation. An initial cross-validation of the automated left-right phase asymmetry measure was performed by correlating the measure with other objective and subjective assessments of phase asymmetry. Results: Vocal fold vibratory asymmetry was exhibited to a similar extent in both comfortable and pressed phonations. The automated measure of left-right phase asymmetry strongly correlated with manually derived measures and moderately correlated with visual-perceptual ratings. Correlations with the visual-perceptual ratings remained relatively consistent as the automated measure was derived from kymograms taken at different glottal locations. Conclusions: An automated HSV-based framework for the quantification of vocal fold vibratory asymmetry was developed and initially validated. This framework serves as a platform for investigating relationships between vocal fold tissue motion and acoustic measures of voice function.

Paper
M. Döllinger, J. B. Kobler, D. A. Berry, D. D. Mehta, G. Luegmair, and C. Bohr, “Experiments on analysing voice production: Excised (human, animal) and in vivo (animal) approaches,” Current Bioinformatics, vol. 6, no. 3, pp. 286-304, 2011. Publisher's Version Paper
D. D. Mehta, S. M. Zeitels, J. A. Burns, A. D. Friedman, D. D. Deliyski, and R. E. Hillman, “High-speed videoendoscopic analysis of relationships between cepstral-based acoustic measures and voice production mechanisms in patients undergoing phonomicrosurgery,” Proceedings of the American Laryngological Association. 2011.

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