Publications by Year: In Press

In Press
J. T. Heaton, et al., “Aerodynamically driven phonation of individual vocal folds under general anesthesia in canines,” The Laryngoscope, In Press. Publisher's VersionAbstract


We previously developed an instrument called the Aerodynamic Vocal Fold Driver (AVFD) for intraoperative magnified assessment of vocal fold (VF) vibration during microlaryngoscopy under general anesthesia. Excised larynx testing showed that the AVFD could provide useful information about the vibratory characteristics of each VF independently. The present investigation expands those findings by testing new iterations of the AVFD during microlaryngoscopy in the canine model.

Study Design

Animal model.


The AVFD is a handheld instrument that is positioned to contact the phonatory mucosa of either VF during microlaryngoscopy. Airflow delivered through the AVFD shaft to the subglottis drives the VF into phonation‐like vibration, which enables magnified observation of mucosal‐wave function with stroboscopy or high‐speed video. AVFD‐driven phonation was tested intraoperatively (n = 26 VFs) using either the original instrument design or smaller and larger versions three‐dimensionally printed from a medical grade polymer. A high‐fidelity pressure sensor embedded within the AVFD measured VF contact pressure. Characteristics of individual VF phonation were compared with typical two‐fold phonation and compared for VFs scarred by electrocautery (n = 4) versus controls (n = 22).


Phonation was successful in all 26 VFs, even when scar prevented conventional bilateral phonation. The 15‐mm‐wide AVFD fits best within the anteroposterior dimension of the musculo‐membranous VF, and VF contact pressure correlated with acoustic output, driving pressures, and visible modes of vibration.


The AVFD can reveal magnified vibratory characteristics of individual VFs during microlaryngoscopy (e.g., without needing patient participation), potentially providing information that is not apparent or available during conventional awake phonation, which might facilitate phonosurgical decision making.

Level of Evidence


D. D. Deliyski, et al., “Laser-calibrated system for transnasal fiberoptic laryngeal high-speed videoendoscopy,” Journal of Voice, In Press.
H. Ghasemzadeh, D. D. Deliyski, D. S. Ford, J. B. Kobler, R. E. Hillman, and D. D. Mehta, “Method for vertical calibration of laser-projection transnasal fiberoptic high-speed videoendoscopy,” Journal of Voice, In Press. Publisher's VersionAbstract
The ability to provide absolute calibrated measurement of the laryngeal structures during phonation is of paramount importance to voice science and clinical practice. Calibrated three-dimensional measurement could provide essential information for modeling purposes, for studying the developmental aspects of vocal fold vibration, for refining functional voice assessment and treatment outcomes evaluation, and for more accurate staging and grading of laryngeal disease. Recently, a laser-calibrated transnasal fiberoptic endoscope compatible with high-speed videoendoscopy (HSV) and capable of providing three-dimensional measurements was developed. The optical principle employed is to project a grid of 7 × 7 green laser points across the field of view (FOV) at an angle relative to the imaging axis, such that (after calibration) the position of each laser point within the FOV encodes the vertical distance from the tip of the endoscope to the laryngeal tissues. The purpose of this study was to develop a precise method for vertical calibration of the endoscope. Investigating the position of the laser points showed that, besides the vertical distance, they also depend on the parameters of the lens coupler, including the FOV position within the image frame and the rotation angle of the endoscope. The presented automatic calibration method was developed to compensate for the effect of these parameters. Statistical image processing and pattern recognition were used to detect the FOV, the center of FOV, and the fiducial marker. This step normalizes the HSV frames to a standard coordinate system and removes the dependence of the laser-point positions on the parameters of the lens coupler. Then, using a statistical learning technique, a calibration protocol was developed to model the trajectories of all laser points as the working distance was varied. Finally, a set of experiments was conducted to measure the accuracy and reliability of every step of the procedure. The system was able to measure absolute vertical distance with mean percent error in the range of 1.7% to 4.7%, depending on the working distance.
M. E. Powell, et al., “Efficacy of videostroboscopy and high-speed videoendoscopy to obtain functional outcomes from perioperative ratings in patients with mass lesions,” Journal of Voice, In Press. Publisher's Version