Assessing the localization accuracy and clinical utility of electric and magnetic source imaging in children with epilepsy

Citation:

Eleonora Tamilia, Michel Alhilani, Naoaki Tanaka, Melissa Tsuboyama, Jurriaan M Peters, P. Ellen Grant, Joseph R Madsen, Steven M Stufflebeam, Phillip L. Pearl, and Christos Papadelis. 2019. “Assessing the localization accuracy and clinical utility of electric and magnetic source imaging in children with epilepsy.” Clin Neurophysiol, 130, 4, Pp. 491-504. Publisher's Version

Abstract:

OBJECTIVE: To evaluate the accuracy and clinical utility of conventional 21-channel EEG (conv-EEG), 72-channel high-density EEG (HD-EEG) and 306-channel MEG in localizing interictal epileptiform discharges (IEDs). METHODS: Twenty-four children who underwent epilepsy surgery were studied. IEDs on conv-EEG, HD-EEG, MEG and intracranial EEG (iEEG) were localized using equivalent current dipoles and dynamical statistical parametric mapping (dSPM). We compared the localization error (E) with respect to the ground-truth Irritative Zone (IZ), defined by iEEG sources, between non-invasive modalities and the distance from resection (D) between good- (Engel 1) and poor-outcomes. For each patient, we estimated the resection percentage of IED sources and tested whether it predicted outcome. RESULTS: MEG presented lower E than HD-EEG and conv-EEG. For all modalities, D was shorter in good-outcome than poor-outcome patients, but only the resection percentage of the ground-truth IZ and MEG-IZ predicted surgical outcome. CONCLUSIONS: MEG localizes the IZ more accurately than conv-EEG and HD-EEG. MSI may help the presurgical evaluation in terms of patient's outcome prediction. The promising clinical value of ESI for both conv-EEG and HD-EEG prompts the use of higher-density EEG-systems to possibly achieve MEG performance. SIGNIFICANCE: Localizing the IZ non-invasively with MSI/ESI facilitates presurgical evaluation and surgical prognosis assessment.
Last updated on 04/08/2020