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The mutational landscape of early‐ and typical‐onset oral tongue squamous cell carcinoma

January 5, 2021
An international multicenter consortium of investigators, including the Faden lab, conducted the largest study to date a characterizing the somatic mutational landscape of oral tongue cancers from young patients without known risk factors. Read the article published in Cancer, here. Read more about The mutational landscape of early‐ and typical‐onset oral tongue squamous cell carcinoma

Human Papillomavirus in Sinonasal Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis

January 5, 2021

As described in a new manuscript published in the journal Cancers, 26% of sinonasal squamous cell carcinomas have detectable HPV. Interestingly, HPV prevalence was higher in subsites with high exposure to secretion flow compared to low exposure subsites and HPV prevalence followed the global distribution of HPV+ oropharyngeal squamous cell carcinoma. This manuscript is the largest analysis of HPV in...

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VTX-2337-HN-001: a neoadjuvant combination immunotherapy trial opens at Boston Medical Center

October 21, 2020

VTX-2337-HN-001 A Phase 1b Multicenter Pre-Surgical Study to Evaluate Immune Biomarker Modulation in Response to Motolimod (VTX-2337) in Combination with Nivolumab in Subjects with Resectable Squamous Cell Carcinoma of the Head and Neck (SCCHN) will be activated this week at Boston Medical Center. The study is open to patients with a new diagnosis of head and neck squamous cell carcinoma who will be undergoing surgical...

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Work from the Faden Lab demonstrates the clinical, genomic and viromic landscape of patients with multiple HPV+ head and neck cancers

October 21, 2020

The incidence of HPV related head and neck cancers (HPV+ HNC) is increasing significantly in the United States. Concomitantly, we are now seeing patients present with, or develop, multiple HPV+ HNCs, which previously was not a clinical scenario that was thought to occur. This year The Faden Lab, along with colleagues at the University of Pittsburgh, Vanderbilt and the National Cancer Institute ...

Read more about Work from the Faden Lab demonstrates the clinical, genomic and viromic landscape of patients with multiple HPV+ head and neck cancers

Mao Lin joins Faden Lab

June 10, 2020
Maoxuan (Mao) is a computational biologist and a former radiologist. He earned his medical degree from China Medical University, Shenyang, China. He switched his career from radiology to bioinformatics impressed by the great translational capability of bioinformatics and its significant benefits for human health. He received his Master and Doctorate degrees in Bioinformatics and Genomics from the University of North Carolina at Charlotte and had worked at the University of Michigan on human cardiovascular genomics and at the Forsyth Institute on the human oral microbiome. His Post-doctoral... Read more about Mao Lin joins Faden Lab