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Early kinetics of ctHPVDNA following surgery for HPV+OPSCC could serve as a biomarker for selecting adjuvant treatment

February 11, 2022

What happens to ctHPVDNA immediately after surgery for an HPV-associated cancer?

HPV+OPSCC is increasing at epidemic proportions and is commonly treated with transoral robotic surgery(TORS). A new manuscript published by the Faden Lab describes results from a prospective study examining the early clearance kinetics of ctHPVDNA following TORS. Using frequent blood draws immediately after surgery they found that ctHPVDNA levels drop rapidly and clear within hours in patients who lack risk factors for residual disease (RD),...

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