I am excited to be moving to the University of Michigan, Ann Arbor as an Assistant Professor in the Department of Biomedical Engineering in May 2017! Please visit our new lab page HERE.
The goal of my research, currently funded by an NCI K99/R00 Pathway to Independence Award, is to understand, at a single-cell level, mechanisms of adaptive resistance and fractional responses of cancer cells to targeted inhibition of oncogenic pathways. I am currently focusing on melanoma (the deadliest form of skin cancer) and drugs targeting the BRAFV600E oncoprotein. My work applies a combination of multiplex biochemical measurement, single-cell analysis and network-level computational modeling to link the observed diversity of drug-induced changes in signaling biochemistry to consequential changes in cell state and cell fate, and aims at developing biomarkers of drug adaptation to guide precision treatment strategies that mitigate drug resistance.
I received my Ph.D. in Chemical Engineering from the University of Michigan, Ann Arbor in 2012 under the supervision of Jennifer Linderman and Denise Kirschner. During my Ph.D, I worked on an interdisciplinary project that combined multi-scale modeling approaches with experiments on mouse models of tuberculosis to the study of mechanisms by which TNF signaling determines immunity to M. tuberculosis. These multi-scale approaches are applicable to the studies of other complex diseases, particularly cancer, where there is a critical need for bridging studies of therapeutic targets at the molecular scale to the effects of modulation of these targets at the cellular and tissue (tumor) levels. My doctoral thesis won the 2011 Richard and Eleanor Towner Award for Outstanding Ph.D. Research from the University of Michigan.
(2015) NIH K99 Pathway to Independence Award (NCI)
(2013-2015) Life Sciences Research Foundation Postdoctoral Fellowship
(2015) AACR-Aflac Scholar-in-Training Award
(2012) Distinguished Young Scholars Seminar Speaker, University of Washington, Seattle
(2011) Richard and Eleanor Towner Outstanding PhD Research Award, University of Michigan
(2011) Rackham Predoctoral Fellowship, University of Michigan
(2010) Phi Kappa Phi Graduate Award
(2009) Rackham International Student Fellowship, University of Michigan