%PDF-1.3
%
4 0 obj
<>>>/BBox[0 0 612 792]/Length 155>>stream
xν0 OqjXQ&ZbSZR~%7\ Qΐ@4$Î!T=; ёzUjMYigv\?y_e!{[U)7SEa#SĒuÇ5RcVȪX9kU?60
endstream
endobj
3 0 obj
<>>>/BBox[0 0 612 792]/Length 155>>stream
xν0 OqjXQ&ZbSZR~%7\ Qΐ@4$Î!T=; ёzUjMYigv\?y_e!{[U)7SEa#SĒuÇ5RcVȪX9kU?60
endstream
endobj
1 0 obj
<>>>/BBox[0 0 612 792]/Length 155>>stream
xν0 OqjXQ&ZbSZR~%7\ Qΐ@4$Î!T=; ёzUjMYigv\?y_e!{[U)7SEa#SĒuÇ5RcVȪX9kU?60
endstream
endobj
6 0 obj
<>stream
Acrobat Distiller 8.1.0 (Windows); modified using iText 4.2.0 by 1T3XT
Arbortext Advanced Print Publisher 9.0.114/W
2018-09-17T10:15:54-07:00
2018-07-11T23:31:19+05:30
application/pdf
ACM-2018-29047-vtn-ver9-Napadow_3P 621..623
uuid:c0581498-b855-4a60-bb18-efb443889e20
uuid:9e64573c-73f9-4074-bb3b-4913b9b51e7f
endstream
endobj
7 0 obj
<>stream
x+ |
endstream
endobj
8 0 obj
<>stream
xS**T0T0 Bi y8#
endstream
endobj
9 0 obj
<>stream
x+ |
endstream
endobj
10 0 obj
<>stream
xS**T0T0 Bi yA$
endstream
endobj
11 0 obj
<>stream
x+ |
endstream
endobj
12 0 obj
<>stream
xS**T0T0 Bi yJ%
endstream
endobj
14 0 obj
<>stream
/GS1 gs
BT
/F5 1 Tf
9.843 0 0 9.843 62.022 725.1588 Tm
0 0 0 rg
-.0226 Tc
0 Tw
[(device)-387.7(d)5.1(e)-1.8(si)5(gners)-386.4(and)-380.8(r)-.6(es)5.3(ear)5.1(chers)-386.4(l)5(earn)-386.6(f)5.1(r)-.6(om)-382(th)5.1(e)-387.7(e)3.9(xtensi)5(ve)-382(re-)]TJ
0 -1.1174 TD
-.0223 Tc
[(search)-587.8(ev)5.4(idence)-583.2(bas)5.6(e)-589(su)5.4(ppo)5.4(rti)5.3(n)-.4(g)-587.8(a)4.2(cup)5.4(unctur)5.4(e)-1.5(?)-589(S)5.6(uch)-582.1(c)-1.5(ro)5.4(ss-)]TJ
0 -1.1116 TD
-.0228 Tc
[(ferti)4.8(lizati)4.8(o)-.9(n)-363.7(i)4.8(n)-363.7(r)-.8(esearch)-358(h)-.9(as)-357.8(been)-363.7(lack)4.9(ing)4.9(,)-366.1(as)-363.5(to)4.9(uch)4.9(e)-2(d)-358(upo)4.9(n)-363.7(b)-.9(y)]TJ
T*
-.0225 Tc
[(ou)5.2(r)-334.6(p)-.6(r)5.2(e)-1.7(vi)5.1(ous)-328.7(review,)]TJ
7.3823 0 0 6.5614 140.7118 696.6423 Tm
0 Tc
(2)Tj
9.843 0 0 9.843 147.4582 692.277 Tm
.311 Tc
[(a)331.8(n)338.7(ds)333.1(h)338.7(o)332.9(u)332.9(l)338.6(db)332.9(eb)332.9(e)337.5(t)332.8(t)332.8(e)337.5(rp)338.7(r)333(o)332.9(m)337.5(o)332.9(t)332.8(e)337.5(d)332.9(.)]TJ
-7.6662 -1.1116 TD
-.0217 Tc
[(In)-270.5(our)-270.4(cu)-5.5(rre)-6.7(nt)-270.6(hea)-6.7(lthc)-6.7(a)-.9(re)-271.6(sy)-5.5(ste)-6.7(m)-1(,)-267(t).1(h)-5.5(e)-.9(re)-271.6(is)-270.3(gr)-5.5(owi)-5.6(n).2(g)-270.5(i).1(nt)-5.6(eres)-5.3(t)-264.8(i)-5.6(n)]TJ
-1.0137 -1.1174 TD
-.0214 Tc
[(no)-5.2(nph)-5.2(arma)-6.4(col)-5.3(ogi)-5.3(cal)-408.5(neu)-5.2(r).6(omo)-5.2(dul)-5.3(ati)-5.3(o).5(n)-402.6(d)-5.2(evi)-5.3(ce-)-5.2(bas)-5(e)-.6(d)-402.6(t)-5.3(her)-5.2(a)-.6(pi)-5.3(es.)]TJ
0 -1.1116 TD
[(Ne)-6.4(uro)-5.2(m)-.7(odu)-5.2(lat)-5.3(i).4(on)-183.8(i)-5.3(s)-183.6(an)-183.8(umb)-5.2(r).6(el)-5.3(la)-184.9(ter)-5.2(m)-185(for)-183.7(a)-184.9(c)-6.4(l).4(as)-5(s)-183.6(o).5(f)-183.7(i).4(n)-5.2(t).4(er)-5.2(vent)-5.3(ion)-5.2(s)]TJ
T*
-.02 Tc
[(that)-395.6(ac)-5(t)-395.6(d)1.9(irectly)-395.5(upon)-395.5(nerves,)-397.8(u)]TJ
12.5619 0 TD
-.0217 Tc
[(s)-5.3(u).2(al)-5.6(ly)-397.2(th)-5.5(os)-5.3(e)-398.3(o).2(f)-397.1(t)-5.6(he)-398.3(pe)-6.7(rip)-5.5(h).2(era)-6.7(l)]TJ
-12.5619 -1.1174 TD
-.0215 Tc
[(ne)-6.5(rvo)-5.3(u).4(s)-275.8(s)-5.1(ys)-5.1(tem.)-278.4(I)-5.3(n)-276(fa)-6.5(ct,)-278.4(n)-5.3(euro)-5.3(mo)]TJ
12.896 0 TD
-.0205 Tc
[(dulation)-280.8(and)-280.8(e).3(le)-5.5(ctricity-base)-5.5(d)]TJ
-12.896 -1.1116 TD
-.0216 Tc
[(me)-6.6(dica)-6.6(l)-241.7(i)-5.5(nte)-6.6(r).4(ve)-6.6(nti)-5.5(ons)-247.1(ha)-6.6(ve)-248.5(been)-247.3(ar)-5.4(oun)-5.4(d)-241.6(f)-5.4(or)-247.3(hun)-5.4(dre)-6.6(d).3(s)-247.1(o).3(f)-247.3(y).3(ea)-6.6(rs,)]TJ
7.3823 0 0 6.5614 297.4109 630.8786 Tm
0 Tc
(3)Tj
9.843 0 0 9.843 62.022 615.5715 Tm
-.0192 Tc
[(from)-476.5(e)-4.2(l)2.6(ec)-4.2(tric)-476.5(eels)-475.1(t)-3.1(o)-475.3(m)1.5(odern)-475.3(a)1.6(pp)]TJ
13.6217 0 TD
-.0217 Tc
[(lic)-6.7(ati)-5.6(ons)-483.4(of)-483.5(tra)-6.7(n).2(sc)-6.7(utan)-5.5(eou)-5.5(s)]TJ
-13.6217 -1.1174 TD
-.0201 Tc
[(electrica)-5.1(l)-389.9(n)-3.9(erve)-396.7(stimulation)-389.8(\()-3.9(TENS\))-389.8(devic)-5.1(e).7(s)-389.6(f)-3.9(or)-395.5(pain)-389.8(control.)]TJ
0 -1.1116 TD
-.0216 Tc
[(Su)-5.4(ch)-316.4(i)-5.5(n).3(te)-6.6(rven)-5.4(tio)-5.4(ns)-316.2(a)-6.6(lte)-6.6(r,)-318.8(or)-322.2()52.2()-5.4(modu)-5.4(late)-6.6(,)52.2()-322.2(n).3(er)-5.4(ve)-317.6(ac)-6.6(tiv)-5.4(ity)-322.2(by)-316.4(de)-6.6(-)]TJ
T*
-.0204 Tc
[(livering)-274.9(elec)-5.4(trical)-269.3(impulse)]TJ
10.0334 0 TD
-.0214 Tc
[(s)-275.7(d).5(ir)-5.2(ect)-5.3(ly)-270.2(to)-275.9(tar)-5.2(g).5(et)-270.3(n)-5.2(e)-.6(rv)-5.2(es.)]TJ
-9.0197 -1.1116 TD
-.0157 Tc
[(Ther)-15.7(e)-312.8(i).4(s)-321.9(n)-15.7(o)10.9(w)-322.9(gr)-15.7(o)10.9(w)-.4(ing)-327.8(i).4(nte)-15.7(r)9.8(est)-328(b).5(y)-322.1(t).4(he)-329(biome)-15.7(d)9.7(ical)-327.9(and)-322.1(e)-.7(v)-15.7(e)9.7(n)]TJ
-1.0137 -1.1174 TD
-.0159 Tc
[(ph)-15.9(a)9.5(r).3(mace)-15.9(u)9.5(tica)-15.9(l)-359.2(ind)-15.9(u)10.7(str)-15.9(y)-357.9(for)-374.1(more)-369.5(t)-15.9(a)9.4(rget)-15.9(e)9.4(d)-368.3(e)-.9(le)-15.9(c)8.4(t).2(ri)-15.9(c)9.4(a)-.9(l)-368.5(s)-15.9(t)10.8(i).2(mul)-15.9(a)9.4(-)]TJ
0 -1.1116 TD
[(ti)-16(o)10.5(n)-374.2(th)-16(e)9.4(r).2(api)-16(e)9.3(s,)-376.5(fo)-16(r)-363.7(bot)-16(h)-363.9(p).2(ai)-16(n)-363.9(a)-1(nd)-380(nonp)-16(a)9.4(i).1(n)-374.2(i)-16(n)10.5(d).2(ica)-16(t)9.3(ion)-16(s)10.8(.)-376.5(A)-.7(t)-374.3(t)-16(h)10.5(e)]TJ
T*
-.0158 Tc
[(U.S.)-399.4(Na)-15.8(t)9.5(i).3(ona)-15.8(l)-387.9(Ins)-15.8(t)10.9(itu)-15.8(t)10.7(e)-.8(s)-396.8(o)-15.8(f)-386.6(H)-.5(eal)-15.8(t)10.5(h).4(,)-399.4(t).3(he)-404(Common)-397(F)-15.8(u)11(nd)-15.8(s)-386.4(S).5(ti)-15.8(-)]TJ
0 -1.1174 TD
-.0159 Tc
[(mul)-15.9(a)9.4(tin)-15.9(g)-317.6(P)-15.9(e)9.7(r).3(iph)-15.9(e)9.5(ral)-333.9(A)-.6(c)-15.9(t)9.4(ivit)-15.9(y)-317.7(t)-15.9(o)-323.5(R)-.7(elie)-15.9(v)9.5(e)-329.2(C)-15.9(o)9.7(ndi)-15.9(t)10.4(i).2(on)-15.9(s)-317.4(\()-15.9(S)10.9(P).4(AR)-15.9(C)8.6(\))]TJ
0 -1.1116 TD
-.0161 Tc
[(is)-345.3(no)-16.1(w)-330.2(f).1(o)-16.1(c)9.3(use)-16.1(d)-330.5(on)-345.5(und)-16.1(e)9.3(r).1(s)-16.1(t)10.6(andi)-16.1(n)10.4(g)-339.7(n)-16.1(e)9.3(rve)-16.1()9.3(org)-16.1(a)9.3(n)-339.7(i)-16.1(n)10.4(tera)-16.1(c)8.2(tio)-16.1(n)10.5(s)-345.3(to)]TJ
T*
-.0156 Tc
[(ul)-15.6(t)10.7(i).5(mat)-15.6(e)9.7(l).5(y)-362.3(a)-15.6(d)9.8(v).6(anc)-15.6(e)-354.2(th)-15.6(e)-353(n).6(eu)-15.6(r)11(o).6(mod)-15.6(u)11(lat)-15.6(i)10.7(on)-368(eld)-368(towa)-15.6(r)9.9(d)-362.3(p)-15.6(r)11(eci)-15.6(s)11.1(e)]TJ
0 -1.1174 TD
0 Tc
[(t)16.1(r)0(e)25.5(a)15(t)16.1(m)15(e)15(n)0(t)-359.4(o)16.2(f)-375.4(d)16.2(i)16.1(s)0(e)25.6(a)15(s)16.4(e)15(s)-375.3(a)15(n)16.2(d)-375.5(c)15(o)16.2(n)16.2(d)0(i)26.5(t)16.1(i)16.1(o)16.2(ns)-359.1(f)16.2(o)0(r)-359.3(w)15.3(hi)26.5(c)15(h)-369.7(co)25.4(n)16.2(v)16.2(e)15(nt)26.5(i)16.1(o)16.2(na)25.4(l)]TJ
0 -1.1116 TD
-.0158 Tc
[(th)-15.8(e)9.6(r).4(api)-15.8(e)9.5(s)-419.9(f).4(all)-420.2(s)-15.8(h)11(ort)-15.8(.)14.1(*)-420.1(I)-15.8(n)-403.9(f)-15.8(a)9.7(ct,)-422.4(a)-421.2(recen)-15.8(t)-404(p)-15.8(u)10.8(b).4(li)-15.8(c)9.5(a)-.8(tio)-15.8(n)-409.7(i).3(n)]TJ
/F6 1 Tf
21.5874 0 TD
-.0159 Tc
[(Natur)-15.9(e)]TJ
/F5 1 Tf
-21.5874 -1.1116 TD
-.0156 Tc
[(su)-15.6(g)11(g).6(es)-15.6(t)11.1(s)-460(th)-15.6(a)9.8(t)-460.3(man)-15.6(y)-449.8(n).6(eur)-15.6(o)11(modu)-15.6(l)10.9(a)-.6(to)-15.6(r)11(y)-460.2(the)-15.6(r)9.9(api)-15.6(e)9.7(s)-460(can)-466(be)-461.4(co)-15.6(n)11(-)]TJ
0 -1.1174 TD
-.0159 Tc
[(si)-15.9(d)10.6(e)-.9(re)-15.9(d)-382.1()46.4(ele)-15.9(c)8.4(t).2(ro)-15.9(c)9.5(e)-.9(uti)-15.9(c)9.4(als)-15.9(,)14.3()46.4()-397.1(or)-397.1(in)-391.4(o)-15.9(t)10.6(her)-397.1(w)-.6(or)-15.9(d)10.7(s)-396.9(medic)-15.9(i)9.4(n).3(es)-396.9(th)-15.9(a)9.5(t)]TJ
0 -1.1116 TD
-.0156 Tc
[(us)-15.6(e)-231.9(e)-.6(l)-15.6(e)9.7(ctr)-15.6(i)10.9(cal)-247.2(impu)-15.6(l)10.9(s).8(es)-246.9(\(a)-15.6(s)-231.9(o)-15.6(p)11(pos)-15.6(e)10(d)-241.3(t)-15.6(o)-231(p)-15.6(h)11(armac)-15.6(o)9.8(l).5(og)-15.6(i)10.9(cal)-247.2(agen)-15.6(t)10.9(s).8(,)]TJ
T*
-.0159 Tc
[(as)-333.6(i)-15.9(n)-323.5()52.2().3(p)-15.9(h)10.7(arma)-15.9(c)8.4(e)-.9(uti)-15.9(c)9.4(als)-15.9()62.8(\))-333.7(t)-15.9(o)-323.5(modul)-15.9(a)9.4(t).2(e)-334.9(b).3(o)-15.9(d)10.7(y)-333.8(phy)-15.9(s)10.9(i).2(ol)-15.9(o)10.6(gy.)]TJ
7.3823 0 0 6.5614 280.5165 444.5857 Tm
0 Tc
(4)Tj
9.843 0 0 9.843 72 429.2786 Tm
-.0222 Tc
[(In)5.5(terest)5.4(ing)5.5(l)-.4(y,)-423(many)-426.5(n)5.5(e)-1.4(ur)5.5(omo)5.5(dul)5.4(at)5.4(ory)-426.5(t)5.4(her)5.5(a)-1.4(pi)5.4(es)-426.3(target)-426.6(cu)5.5(ta-)]TJ
-1.0137 -1.1174 TD
-.0226 Tc
[(neous)5.3(ly)-513.3(accessi)5(ble)-508.7(p)-.7(er)5.1(iph)5.1(e)-1.8(ral)-513.4(n)]TJ
12.631 0 TD
-.0229 Tc
[(erves)-513.4(a)-2.1(n)4.8(d)-513.6(recepto)4.8(r)-.9(s.)-510.1(In)-507.8(turn)4.8(,)]TJ
-12.631 -1.1116 TD
-.0215 Tc
[(ac)5(upu)6.2(nct)6.1(u).4(re)-450(i)6.1(n)-448.8(gen)6.2(e)-.7(ra)5(l,)-445.4(and)-448.8(e)5(lec)5(t).3(ro)6.2(acu)6.2(pun)6.2(ctu)6.2(r).5(e)-450(i).3(n)-448.8(p)6.2(art)6.1(i).3(cu)6.2(la)5(r,)]TJ
T*
-.0225 Tc
[(wh)5.2(ich)-530.4(c)-1.7(ou)5.2(ples)-536(metalli)5.1(c)-537.4(\()-.5(cond)5.2(uctiv)5.2(e\))-536.2(n)5.2(eed)5.2(les)-530.3(w)-1.4(it)5.1(h)-536.2(e)-1.7(l)5.1(e)-1.7(ctrical)]TJ
0 -1.1174 TD
-.0277 Tc
[(s)-5.6(t)-5.9(im)-7(ul)-5.9(a)-6.9(t)-.1(i)-5.9(o)-5.8(n,)]TJ
7.3823 0 0 6.5614 106.1858 389.7637 Tm
0 Tc
(5)Tj
9.843 0 0 9.843 112.422 385.3983 Tm
-.022 Tc
[(sig)5.7(n)-.1(i)5.9(can)5.7(tly)-282.3(ov)5.7(erl)5.6(a)-1.2(p)-282.3(w)-.9(it)5.6(h)-288(m)4.5(any)-282.3(n)-.1(ew)-283.2(techno)5.7(log)5.7(i)-.2(es)]TJ
-5.1204 -1.1116 TD
-.0224 Tc
[(falli)5.2(ng)-196.3(und)5.3(er)-196.3(th)5.3(is)-196.1(bro)5.3(a)-1.6(d)-196.3(n)-.5(euromod)5.3(u)-.5(latio)5.3(n)-196.3(u)-.5(mb)5.3(rel)5.2(l)-.6(a.)-192.9(For)-196.3(i)-.6(n)5.3(s)-.3(tance,)]TJ
T*
-.0214 Tc
[(re)5.1(sea)5.1(r).6(ch)6.3(ers)-431.2(h).5(av)6.3(e)-438.4(e)-.6(v)6.3(e)-.6(n)-437.2(r)6.3(efe)5.1(rre)5.1(d)-437.2(t).4(o)-431.4(cer)6.3(tai)6.2(n)-437.2(fo)6.3(rm)5.1(s)-437(o).5(f)-437.2(T)5.1(EN)5.4(S)-437(a)-.6(s)]TJ
0 -1.1174 TD
-.0228 Tc
[()51()-.8(acup)4.9(unctur)4.9(e)-2(-l)4.8(ike)51()-277.3(T)3.7(ENS)5.1(,)-279.7(when)-277.3(usi)4.8(n)-.9(g)-277.3(l)4.8(ow-)4.9(frequency)-271.6(s)-.7(ti)4.8(mu)4.9(la-)]TJ
0 -1.1116 TD
-.0222 Tc
[(ti)5.4(on,)-238.7(acu)5.5(poi)5.4(nt)-242.3(targetin)5.5(g,)-244.5(etc.)]TJ
7.3823 0 0 6.5614 166.4503 345.9401 Tm
0 Tc
(6)Tj
9.843 0 0 9.843 172.2897 341.5747 Tm
-.0226 Tc
[(Mor)5.1(e)-1.8(ov)5.1(er,)-239.1(e)-1.8(lectr)5.1(o)-.7(acup)5.1(unctur)5.1(e)-249.5(and)]TJ
-11.2026 -1.1116 TD
-.022 Tc
[(TENS)-512.5(may)-506.9(b)-.1(e)-513.8(m)4.5(odu)5.7(lat)5.6(i)-.2(ng)-506.9(similar)-512.6(a)-1.2(n)5.7(a)-1.2(to)5.7(mi)5.6(cal)-507(tar)5.7(g)-.1(et)5.6(s.)]TJ
7.3823 0 0 6.5614 277.6818 334.9983 Tm
0 Tc
(7)Tj
9.843 0 0 9.843 286.2425 330.633 Tm
-.0242 Tc
(The)Tj
-22.7796 -1.1116 TD
-.0273 Tc
[(w)-6.2(e)-.8(a)-6.5(l)-5.5(th)-258.8(of)-258.8(re)-6.5(s)-5.2(e)-.8(a)-6.5(r)-5.3(ch)-258.8(al)-5.5(r)-5.3(e)-.8(a)-6.5(d)-5.4(y)-253(p)-5.4(ub)-5.4(l)-5.5(i).3(s)-5.2(h)-5.4(ed)-258.8(co)-5.4(v)-5.4(e)-.8(r)-5.3(i)-5.5(ng)-258.8(ne)-6.5(u)-5.4(r).4(o)-5.4(m)-6.6(od)-5.4(ul)-5.5(a)-6.5(t).3(i)-5.5(o)-5.4(n)]TJ
0 -1.1174 TD
-.0214 Tc
[(an)6.3(d)-299(e)5.1(le)5.1(ctr)6.3(o).5(ac)5.1(upu)6.3(nct)6.2(u).5(re)-294.4(th)6.3(er)6.3(apy)-293.2(n).5(e)5.1(e)-.6(ds)-293(t)6.2(o)-299(b)6.3(e)-300.1(b)6.3(e)-.6(t)6.2(t).4(er)-293.2(in)6.3(teg)6.3(r).6(at)6.2(ed)-293.2(to)]TJ
0 -1.1116 TD
-.0224 Tc
[(fu)5.3(rther)-599.4(o)5.3(ur)-599.4(u)5.3(nderst)5.2(a)-1.6(nd)5.3(ing)-593.7(o)-.5(f)-593.7(m)-1.7(echanis)5.5(m)-1.7(s)-593.5(s)-.3(upp)5.3(ort)5.2(i)-.6(ng)-593.7(th)5.3(ese)]TJ
T*
[(th)5.4(erapies.)-244.6(My)-242.3(con)5.4(t)-.5(en)5.4(tio)5.4(n)-242.3(i)-.5(s)-242.1(t)-.5(h)5.4(a)-1.5(t)-242.4(b)-.4(o)5.4(t)-.5(h)-242.3(o)-.4(f)-242.2(t)5.3(hese)-243.4()5.6(e)-1.5(l)5.3(d)-.4(s)-242.1(h)-.4(av)5.4(e)-243.4(qui)5.3(te)-243.4(a)]TJ
0 -1.1174 TD
-.0222 Tc
[(bi)5.4(t)-282.6(t)-.4(o)-282.5(l)-.4(earn)-282.5(f)5.5(r)-.2(om)-277.9(one)-283.6(anot)5.4(her)5.5(.)-284.8(Turn)5.5(ing)-282.5(a)-283.6(b)5.5(lin)5.5(d)-282.5(e)-1.4(ye)-277.9(to)-282.5(th)5.5(e)-283.6(\()-.2(ob)5.5(vi-)]TJ
0 -1.1116 TD
-.0224 Tc
[(ou)5.3(s\))-190.5(lin)5.3(ks)-190.3(thr)5.3(eat)5.2(ens)-190.3(t)-.6(o)-190.5(r)5.3(etard)-190.5(pot)5.2(ent)5.2(i)-.6(al)5.2(ly)-190.5(valuable)-191.7(advances)-196.1(i)5.2(n)-190.5(our)]TJ
T*
-.0221 Tc
[(un)5.6(der)5.6(s)0(tandi)5.5(ng)-322.7(of)-316.9(how)-323.6(b)5.6(e)-1.3(st)-317.1(to)-322.7(op)5.6(timize)-323.9(p)-.2(r)5.6(o)-.2(mi)5.5(sin)5.6(g)-322.7(dir)5.6(ect)5.5(ion)5.6(s)-322.5(in)]TJ
0 -1.1174 TD
[(perip)5.7(h)-.1(er)5.7(al)-276.7(ner)5.7(v)-.1(e)-277.7(s).1(ti)5.6(mu)5.7(lat)5.6(i)-.2(on)-276.5(th)5.7(erapies.)]TJ
1.0137 -1.1116 TD
-.0159 Tc
[(In)-385.6(fact)-15.9(,)-371.9(m)-.9(ult)-15.9(i)10.4(ple)-386.8(e)-.9(xa)-15.9(m)8.3(p).3(les)-385.4(o).3(f)-385.6(ove)-15.9(r)9.6(l).2(ap)-385.6(or)-385.6(pot)-15.9(e)9.4(n).3(ti)-15.9(a)9.4(l)-380(o)-15.9(v)10.7(erl)-15.9(a)9.4(p)]TJ
-1.0137 -1.1116 TD
[(bet)-15.9(w)9.7(een)-374.1(neur)-15.9(o)10.7(m)-.9(odu)-15.9(l)10.6(a)-.9(tio)-15.9(n)-357.9(a)-.9(nd)-374.1(elec)-15.9(t)9.4(roa)-15.9(c)8.4(upun)-15.9(c)9.5(t).2(ur)-15.9(e)-359(e)-.9(xi)-15.9(s)10.8(t).1(,)-370.7(b).3(o)-15.9(t)10.6(h)]TJ
0 -1.1174 TD
-.0157 Tc
[(in)-299(c)-15.7(o)9.7(ncep)-15.7(t)-288.7(a)-.7(nd)-299(i)-15.7(n)-288.7(pra)-15.7(c)8.6(tice)-15.7(.)-286.3(F)-15.7(o)11.1(r)-299(i).4(ns)-15.7(t)11(a)-.7(nc)-15.7(e)8.6(,)-301.4(elect)-15.7(r)10.8(i).4(cal)-304.9(stimu)-15.7(l)10.8(ati)-15.7(o)10.8(n)]TJ
0 -1.1116 TD
[(app)-15.7(l)10.8(ied)-460.3(t)-15.7(o)-450(t).4(he)-461.5(medi)-15.7(a)9.6(n)-460.3(n).5(erv)-15.7(e)9.7(,)-456.9(w)-15.7(h)10(i).4(ch)-460.3(tr)-15.7(a)9.8(c)-.7(ks)-460.1(t)-15.7(h)10.8(e)-461.5(p).5(eri)-15.7(c)9.6(ardi)-15.7(u)10.8(m)]TJ
T*
[(\(P)-15.8(C)9.9(\))-345.2(merid)-15.8(i)10.7(a)-.8(n)-345.2(w)-.5(ith)-15.8(i)10.7(n)-345.2(the)-346.4(for)-15.8(e)9.7(a)-.8(rm,)-347.5(h).4(as)-345(been)-345.2(s)-15.8(h)11(own)-345.2(t).3(o)-345.2(m)-.8(odu)-15.8(-)]TJ
T*
0 Tc
[(l)16.1(a)0(t)25.3(e)-411.2(e)15(s)0(s)27(e)15(nt)26.5(i)16.1(a)15(l)-415.9(t)16.1(r)16.2(e)15(mo)25.4(r)]TJ
7.3823 0 0 6.5614 142.4126 181.5874 Tm
(8)Tj
9.843 0 0 9.843 150.1795 177.222 Tm
-.0157 Tc
[(and)-431.5(i).4(nd)-15.7(u)10.9(c)-.7(e)-432.7(cardi)-15.7(o)10.8(pro)-15.7(t)10.8(ect)-15.7(i)10.6(v).5(e)-432.7(e)-.7(ffec)-15.7(t)9.6(s)-431.3(i).4(n)]TJ
-8.9563 -1.1174 TD
-.0154 Tc
[(ani)-15.4(m)9.8(al)-368(model)-15.4(s)-357.4(\(e.g.,)-364.4(re)-15.4(d)10(u).8(ced)-367.8(at)-15.4(r)11.1(i).7(al)-368(re)-15.4(m)8.8(odeli)-15.4(n)11.1(g)]TJ
7.3823 0 0 6.5614 246.1606 170.5889 Tm
0 Tc
(9)Tj
9.843 0 0 9.843 253.3039 166.2236 Tm
-.0159 Tc
[(a)-15.9(n)9.5(d)-368.3(r).3(educ)-15.9(e)8.4(d)]TJ
-19.4332 -1.1116 TD
[(ven)-15.9(t)10.6(ric)-15.9(u)9.5(lar)-529.6(a)-.9(rrh)-15.9(y)10.7(t).2(hmi)-15.9(a)]TJ
7.3823 0 0 6.5614 150.3496 159.6472 Tm
-.0162 Tc
(10)Tj
9.843 0 0 9.843 157.4362 155.2818 Tm
-.0158 Tc
[(\).)-526.1(S)-15.8(i)10.8(mila)-15.8(r)9.7(l).3(y,)-526.1(el)-15.8(e)9.5(c)-.8(tr)-15.8(o)10.8(acup)-15.8(u)10.8(nctu)-15.8(r)10.8(e)-524.9(a)-15.8(p)9.6(-)]TJ
-9.6936 -1.1116 TD
[(pl)-15.8(i)10.5(e)-.8(d)-448.9(o)-15.8(v)10.8(e)-.8(r)-454.6(t).3(he)-455.8(PC)-449.9(mer)-15.8(i)10.7(d).4(ia)-15.8(n)-439.6(h).4(as)-454.4(bee)-15.8(n)-439.6(sh)-15.8(o)10.8(w)-.5(n)-454.6(i).3(n)-448.9(a)-455.8(seri)-15.8(e)9.5(s)-448.7(o)-15.8(f)]TJ
0 -1.1174 TD
-.016 Tc
[(st)-16(u)10.5(d).2(ie)-16(s)-301.4(t).1(o)-310.8(r)-16(e)9.5(duce)-312(h)-16(y)10.6(p).2(er)-16(t)10.5(e)-1(ns)-16(i)10.7(on.)]TJ
7.3823 0 0 6.5614 181.9275 137.707 Tm
-.0162 Tc
(11)Tj
9.843 0 0 9.843 192.0755 133.3417 Tm
-.0155 Tc
[(I)-15.5(n)-299.9(fact)-15.5(,)-296.6(t)-15.5(h)11(e)-311.5(ov)-15.5(e)9.9(r).7(lap)-316.1(b).7(etwe)-15.5(e)8.8(n)]TJ
-13.2128 -1.1116 TD
-.0158 Tc
[(med)-15.8(i)10.7(a)-.8(n)-650.5(n).4(e)-15.8(r)9.7(ve)-651.6(ne)-15.8(u)9.6(romo)-15.8(d)10.8(ulat)-15.8(i)10.5(o).4(n)-650.5(a)-.8(n)-15.8(d)-640(PC)-651.5(ac)-15.8(u)9.6(poin)-15.8(t)10.7(-ta)-15.8(r)9.7(get)-15.8(e)9.5(d)]TJ
T*
[(el)-15.7(e)9.6(c)-.7(tro)-15.7(a)9.7(cupu)-15.7(n)10.9(c)-.7(tu)-15.7(r)10.9(e)-265.6(wa)-15.7(s)-255(r).5(e)-15.7(c)8.6(entl)-15.7(y)-254.2(a)-.7(c)-15.7(k)9.7(nowl)-15.7(e)9.6(dged)-270.2(i).4(n)-270.2(a)-265.6(rev)-15.7(i)10.8(ew)-271.1(on)]TJ
0 -1.1174 TD
-.0156 Tc
[(dev)-15.6(i)10.9(ce)-380.7(a)-15.6(p)9.8(plic)-15.6(a)8.7(tio)-15.6(n)11(s)-379.4(fo)-15.6(r)-369.1(car)-15.6(d)11(i).5(ac)-380.7(o)-15.6(u)11(tco)-15.6(m)9.8(es.)]TJ
7.3823 0 0 6.5614 225.581 104.8819 Tm
-.0162 Tc
(12)Tj
9.843 0 0 9.843 236.4094 100.4598 Tm
-.0159 Tc
[(P)-15.9(a)9.7(rti)-15.9(c)9.4(ular)-15.9(l)10.6(y)-379.9(ne)-15.9(a)8.4(r)]TJ
-17.7169 -1.1116 TD
[(th)-15.9(e)-451.2(w)-.6(ri)-15.9(s)10.8(t).2(,)-462.8(t).2(he)-467.4(media)-15.9(n)-451.2(n).3(erv)-15.9(e)-451.2(is)-466.1(quite)-467.4(shal)-15.9(l)10.4(o).3(w)-461.4(\()]TJ
/F12 1 Tf
19.1453 0 TD
0 Tc
(*)Tj
/F5 1 Tf
.9849 0 TD
[(1)-150.8(c)15(m)-445.8(d)16.2(ee)24.3(p)]TJ
5.3738 64.5778 TD
-.0157 Tc
[(f)-15.7(r)11(om)-254.2(th)-15.7(e)-243.7(s).7(ki)-15.7(n)-242.7(s).7(urf)-15.7(a)9.8(ce\))-252.9(a)-15.7(n)9.7(d)-252.9(eas)-15.7(i)11(l).3(y)-252.9(a)-.7(c)-15.7(c)8.6(ess)-15.7(i)11(ble)-254.1(b)-15.7(y)-242.5(a)-.7(n)-252.9(acu)-15.7(p)10.9(unct)-15.7(u)10.8(re)]TJ
0 -1.1174 TD
[(n)-15.8(e)9.6(edl)-15.8(e)9.5(.)-387.9(H)-.5(ence)-392.4(elec)-15.8(t)9.5(roa)-15.8(c)8.5(upun)-15.8(c)9.6(t).2(ur)-15.8(e)-376.2(can)-391.3(be)-386.7(re)-15.8(a)8.5(d).4(il)-15.8(y)-375.2(a)-.8(pp)-15.8(l)10.7(i).2(ed)-391.3(for)]TJ
0 -1.1116 TD
[(m)-15.8(e)8.4(dian)-425.8(ne)-15.8(r)9.7(v).4(e)-427(n).4(eur)-15.8(o)10.8(modu)-15.8(l)10.7(a)-.8(ti)-15.8(o)10.7(n).4(,)-422.4(a)-.8(n)-15.8(d)-409.7(l)-15.8(o)10.7(cal)-15.8(l)10.5(y)-425.8(targe)-15.8(t)9.5(e)-.8(d)-425.8(i).3(ndi)-15.8(c)9.5(a)-.8(-)]TJ
T*
[(t)-15.6(i)10.7(ons)-15.6(,)-365.5(s).8(uch)-379.6(a)-.6(s)-373.6(car)-15.6(p)11(a)-.6(l)-373.9(t)-15.6(u)10.9(nnel)-379.7(s).8(ynd)-15.6(r)11(o).6(me,)-376.1(r)-15.6(e)9.9(spo)-15.6(n)11(d)-373.8(w)-.3(el)-15.6(l)-363.6(t).4(o)-373.8(e)-15.6(l)9.7(ec-)]TJ
T*
-.0161 Tc
[(t)-16.1(r)10.4(oac)-16.1(u)9.3(punc)-16.1(t)9.2(ure)-16.1(,)-517.1(w)-16.1(i)9.5(t)0(h)-529.8(l)-16.1(o)10.4(ngi)-16.1(t)10.2(udi)-16.1(n)10.4(a)-1.1(l)-529.9(i)0(m)-16.1(p)9.3(rove)-16.1(m)8.1(e)-1.1(nts)-535.4(i)-.1(n)-529.8(m)-1.1(e)-16.1(d)9.3(ian)]TJ
0 -1.1174 TD
0 Tc
[(ne)25.4(r)16.2(v)16.2(e)-319(fu)26.6(n)16.2(c)15(ti)26.3(o)16.2(n)-317.9(a)15(n)16.2(d)-317.9(b)0(r)26.6(a)15(i)16(n)-317.9(ne)25.4(u)16.2(r)16.2(o)0(p)26.6(l)16(a)15(s)0(t)26.7(i)16.1(c)15(i)16.1(ty)26.5(.)]TJ
7.3823 0 0 6.5614 471.4014 674.7021 Tm
-.0239 Tc
(13)Tj
9.843 0 0 9.843 323.0361 659.3951 Tm
.0245 Tc
[(An)-5.4(other)-304.9(i).2(mpor)-5.4(tant)-305(poin)-5.4(t)-299.3(i)-5.5(s)-298.9(t)-5.5(h).4(at)-305(cutane)-6.6(ous)-304.7(neuro)-5.4(modu-)]TJ
-1.0137 -1.1116 TD
[(l)-5.6(a)-.9(tion)-224.4(i).1(s)-218.4(non)-5.5(invasi)-5.6(ve,)-220.9(l).1(eadin)-5.5(g)-218.6(t).1(o)-218.6(r).3(e)-6.7(duced)-218.6(ba)-6.7(rrier)-5.5(s)-218.4(for)-224.3(entry)]TJ
0 -1.1174 TD
.0247 Tc
[(b)-5.2(y)-437.2(medi)-5.3(cal)-437.3(de)-6.4(vice)-438.3(c)-6.4(o).6(mpanies)-5(.)-439.5(Sever)-5.2(a)-.6(l)-437.3(c)-.6(omp)-5.2(a)-.6(nies)-442.7(have)]TJ
0 -1.1116 TD
.0116 Tc
[(now)-284.1(d)4.7(e)-2.2(v)4.7(e)-2.2(l)4.6(oped)-283.2(t)-1.1(h)4.7(e)-2.2(rapeut)4.6(ic)-284.4(devi)]TJ
13.1724 0 TD
.0121 Tc
[(ces)-288.3(t)5.1(ar)5.3(geti)5.1(ng)-282.7(medi)5.1(an)-282.7(nerv)5.2(e)]TJ
-13.1724 -1.1116 TD
[(sti)5.2(m)-1.6(u)5.3(l)-.5(ati)5.2(o)-.4(n)-299.9(f)5.4(or)-294.1(vario)5.3(u)-.4(s)-294(i)-.5(nd)5.3(icat)5.2(io)5.3(ns,)-296.5(i)5.2(ncl)5.2(u)-.4(d)5.3(i)-.5(n)5.3(g)-299.9(h)5.3(ypert)5.2(en)5.3(sio)5.3(n)]TJ
0 -1.1174 TD
.0189 Tc
[(\()-5.2(e)-.6(.g.,)-353.1(e)-6.4(C)-.5(oin)-5.2(,)-353.1(by)-356.6(Val)-5.4(e)-.6(nc)-6.4(ia)-352(T)-6.4(echn)-5.2(o).5(lo)-5.2(gie)-6.4(s).7(,)-353.1(a)-.6(n)-356.6(e)-.6(x)-5.2(a)-.6(mpl)-5.4(e)-352(of)-356.5(a)]TJ
0 -1.1116 TD
.012 Tc
[(sub)5.1(c)-1.8(u)5.1(t)-.7(aneo)5.1(us)-530.3(impl)5(an)5.1(ted)-530.5(n)-.6(eur)5.2(o)-.6(st)5(imul)5(at)5(io)5.1(n)-536.3(d)-.6(evi)5(c)-1.8(e\).)-532.8(S)-.4(i)5(m)-1.8(i)5(-)]TJ
T*
.0072 Tc
[(l)-5.5(a)-6.6(rl)-5.5(y,)-197.8(p)-5.4(e)-.8(r)-5.4(c)-.8(u)-5.4(t)-5.5(an)-5.4(eo)-5.4(us)-201.1(ti)-5.5(bi)-5.5(a)-6.6(l)-195.6(ne)-6.6(r)-5.4(v)]TJ
12.1069 0 TD
.0115 Tc
[(e)-192.3(s)-.9(ti)4.5(mu)4.6(latio)4.6(n)-191.2(h)-1.1(as)-196.8(been)-191.2(appl)4.5(ied)]TJ
-12.1069 -1.1116 TD
.0122 Tc
[(by)-340.2(in)5.3(terv)5.3(en)5.3(tio)5.3(nal)-340.4(u)-.4(r)5.4(o)-.4(l)5.2(ogi)5.2(st)5.2(s)-340(for)-340.2(many)-340.2(y)5.3(e)-1.6(ars)-340(f)-.4(o)5.3(r)-340.2(ov)5.3(er)5.4(act)5.2(iv)5.3(e)]TJ
0 -1.1174 TD
.0115 Tc
[(bladd)4.6(e)-2.3(r)4.7(.)]TJ
7.3823 0 0 6.5614 345.9967 565.1148 Tm
.0145 Tc
[(14)14.5(,)-11.1(1)0(5)]TJ
9.843 0 0 9.843 368.6172 560.7495 Tm
.0118 Tc
[(Th)4.9(is)-559.3(cut)4.8(a)-2(n)4.9(e)-2(ou)4.9(s)-559.3(n)-.8(eur)5(o)-.8(mod)4.9(u)-.8(lato)4.9(ry)-559.5(t)4.8(e)-2(chni)4.8(qu)4.9(e)]TJ
-5.6445 -1.1116 TD
.0122 Tc
[(can)-386.3(target)-392.2(a)-393.2(r)5.4(e)-1.6(g)5.3(i)-.5(on)-386.3(cl)5.2(ose)-393.2(t)5.2(o)-392.1(a)4.2(cu)5.3(poi)5.2(nt)-392.2(S)5.5(P)-.3(-)5.4(6)-392.1(on)-392.1(t)5.2(h)-.4(e)-393.2(m)4.1(edial)]TJ
T*
.0117 Tc
[(asp)4.8(e)-2.1(ct)-450.3(of)-450.1(t)4.7(h)-.9(e)-451.3(l)4.7(ower)-450.1(leg,)-446.7(an)4.8(d)-450.2(a)-451.3(recent)-450.3(revi)4.7(ew)-451(o)4.8(f)-450.1(el)4.7(ectro)4.8(-)]TJ
0 -1.1174 TD
.0118 Tc
[(acu)4.9(pu)4.9(nctu)4.9(re)-370.6(fo)4.9(r)-369.4(o)-.8(v)4.9(e)-2(r)5(a)-2(ctiv)4.9(e)-370.6(b)-.8(l)4.8(a)-2(d)4.9(d)-.8(er)-369.4(syn)4.9(t)-.9(h)4.9(e)-2(s)5.1(i)-.9(zed)-369.4(d)-.8(ata)-370.6(f)5(ro)4.9(m)]TJ
0 -1.1116 TD
[(10)-219.7(r)5(a)-2(n)4.9(d)-.8(o)4.9(m)-2(i)4.8(z)-2(ed)-219.7(con)4.9(t)-.9(ro)4.9(ll)4.8(ed)-213.9(tri)4.8(a)-2(l)4.8(s)-.6(,)-216.3()5.1(ndi)4.8(ng)-213.9(su)4.9(ppo)4.9(rt)-214.1(fo)4.9(r)-219.6(r)-.8(edu)4.9(c)-2(ed)]TJ
T*
[(noctu)4.9(ri)4.8(a)-284.2(a)3.8(nd)-277.3(i)4.8(m)-2(p)4.9(rov)4.9(ed)-277.3(q)4.9(u)-.8(alit)4.8(y)-277.3(o)-.8(f)-277.3(l)-.9(i)4.8(f)-.8(e.)]TJ
7.3823 0 0 6.5614 466.0156 510.3495 Tm
0 Tc
(16)Tj
9.843 0 0 9.843 323.0361 494.9857 Tm
-.0218 Tc
[(Anot)5.8(her)-380(i)0(nt)5.8(erest)5.8(i)0(ng)-380(example)-381.2(o)5.9(f)-380(overl)5.8(ap)-380(between)-380(cu)5.9(taneous)]TJ
-1.0137 -1.1116 TD
-.022 Tc
[(neuro)5.7(m)-1.3(odu)5.7(latio)5.7(n)-391.7(a)4.5(nd)-386(acupu)5.7(nctu)5.7(re)-392.9(i)5.6(s)-391.5(with)-386(auricular)-385.9(t)-.2(ranscut)5.6(a)-1.2(-)]TJ
T*
-.0222 Tc
[(neous)-483.9(vag)5.5(u)-.3(s)-489.6(n)-.3(erve)-485.2(stimulati)5.4(on,)]TJ
7.3823 0 0 6.5614 436.1385 477.4676 Tm
-.0315 Tc
(17)Tj
9.843 0 0 9.843 447.8739 473.1022 Tm
-.0243 Tc
[(w)-3.2(h)-2.4(ich)-491.9(h)-2.4(as)-491.7(be)-3.5(en)-491.9(show)-3.2(n)-486.2(t)-2.5(o)]TJ
-13.6966 -1.1174 TD
-.0212 Tc
[(modu)6.5(late)-242.3(fun)6.5(c)-.4(tio)6.5(n)-246.9(i)6.4(n)-246.9(s).9(e)5.3(v).7(era)5.3(l)-247.1(v)6.5(i).6(scer)6.5(al)-241.3(organ)6.5(s)-246.7(\()6.5(e)-.4(.g)6.5(.,)-237.7(cardi)6.4(ac)]TJ
7.3823 0 0 6.5614 529.0582 466.5258 Tm
-.0315 Tc
(18)Tj
9.843 0 0 9.843 538.4125 462.1038 Tm
-.0242 Tc
(and)Tj
-22.8948 -1.1116 TD
-.0227 Tc
[(gastro)5(intestinal)]TJ
7.3823 0 0 6.5614 369.8078 455.5274 Tm
-.0315 Tc
(19)Tj
9.843 0 0 9.843 380.1826 451.1621 Tm
-.0219 Tc
[(phy)5.8(siolo)5.8(gy\))-345.5(and)-345.5(t)-.1(y)5.8(p)0(ically)-345.5(targ)5.8(ets)-345.3(a)-346.7(regi)5.7(on)-345.5(of)]TJ
-6.8195 -1.1116 TD
[(the)-162.5(a)-1.2(ur)5.7(icle)-162.5(\(e.g.,)-163.7(cymba)-162.5(a)4.5(nd)-161.3(cav)5.7(um)-162.6(con)5.7(c)-1.2(ha\))-161.3(t)-.2(h)5.7(a)-1.2(t)-161.5(i)-.2(s)-161.1(t)-.2(hou)5.7(ght)-161.5(t)-.2(o)-161.3(m)4.5(ap)]TJ
T*
-.0222 Tc
[(to)-380.4(vi)5.4(sceral)-380.5(o)5.5(r)-.2(gans)-374.4(such)-374.6(as)-374.4(the)-375.8(h)-.3(ear)5.5(t)-380.5(a)-1.4(n)5.5(d)-380.4(gu)5.5(t)-380.5(i)-.4(n)-374.6(a)-1.4(ur)5.5(icular)-380.4(acu-)]TJ
0 -1.1174 TD
-.0217 Tc
[(punct)5.9(u).2(re)-179.5(t)5.9(h).2(eor)6(y).2(.)]TJ
7.3823 0 0 6.5614 373.6629 422.6456 Tm
-.0315 Tc
(20)Tj
9.843 0 0 9.843 382.3369 418.2802 Tm
-.0216 Tc
[(St)6(imul)6(ation)-172.4(o).3(f)-178.2(t)6(his)-178(r)6.1(egion)-172.4(h).3(as)-172.3(been)-172.4(show)5.2(n)]TJ
7.3823 0 0 6.5614 536.0314 422.6456 Tm
-.0315 Tc
(21)Tj
9.843 0 0 9.843 544.7054 418.2802 Tm
-.0218 Tc
(to)Tj
-23.5342 -1.1116 TD
[(activ)6(ate)-277.4(n)6(uclei)-270.6(\().3(i.e.,)-272.8(nucleus)-276(t)5.9(r).3(act)5.9(us)-276(soli)5.9(tarii)5.9(\))-276.2(cont)5.9(ainin)6(g)-276.2(the)-277.4(p)6(ri-)]TJ
T*
-.0221 Tc
[(mary)-414.8(brai)5.5(nstem)-416.1(s)0(ynapse)-421.8(f)5.6(or)-420.6(th)5.6(e)-421.8(v)-.2(agus)-420.4(nerve,)-417.2(wh)5.6(ose)-421.8(e)4.4(fferent)]TJ
0 -1.1174 TD
-.0219 Tc
[(bers)-287.8(a)4.6(re)-289.1(kn)5.8(own)-287.9(t)-.1(o)-282.2(i)-.1(nnervate)-283.3(t)-.1(he)-289.1(h)5.8(eart)-288.1(a)4.6(nd)-287.9(th)5.8(e)-289.1(gut.)-284.5(E)-1.2(v)5.8(e)-1.1(n)-287.9(m)-1.2(o)5.8(r).1(e)]TJ
0 -1.1116 TD
-.0215 Tc
[(inter)6.2(e)-.7(stin)6.2(gly,)-261.1(such)-264.5(br)6.2(ainst)6.1(e)-.7(m)-265.7(act)6.1(ivat)6.1(ion)-264.5(w)-.4(as)-264.3(fo)6.2(und)-264.5(to)-264.5(b)6.2(e)-265.7(great)6.1(er)]TJ
T*
[(when)-293.4(st)6(imul)6(ation)-293.4(o)6.1(ccur)6.1(s)-299(d)6.1(u).3(ring)-293.4(t)6(h).3(e)-294.6(e)-.8(xh)6.1(alat)6(ory)-293.4(pha)4.9(se)-294.6(of)-293.4(the)-294.6(r)6.1(e-)]TJ
0 -1.1174 TD
[(spirat)6(ory)-506.5(c)-.8(y)6.1(c)-.8(le,)]TJ
7.3823 0 0 6.5614 373.096 356.9385 Tm
-.0315 Tc
(21)Tj
9.843 0 0 9.843 385.0582 352.5164 Tm
-.022 Tc
[(po)5.7(ssibl)5.6(y)-506.9(s).1(uppo)5.7(rting)-506.9(t)-.2(h)5.7(e)-508.1(Chin)5.7(ese)-508.1(m)-1.3(edici)5.6(n)-.1(e)]TJ
-7.3148 -1.1116 TD
-.0223 Tc
[(concept)-282.7(o)-.4(f)-288.3(t)5.3(he)-283.7(impo)5.4(rtance)-289.5(o)5.4(f)-288.3(r)5.4(e)-1.5(spiratory)-282.6(phase)-283.7(for)-282.6(acup)5.4(unctu)5.4(re)]TJ
T*
-.0221 Tc
[(needl)5.5(e)-375.7(in)5.6(serti)5.5(o)-.2(n)-374.5(t)5.5(o)-374.5(a)-1.3(chiev)5.6(e)-375.7(to)5.6(nication)-368.8(a)-1.3(nd)-368.8(disp)5.6(ersio)5.6(n)-.2(,)-371.1(p)-.1(oten-)]TJ
T*
[(tiall)5.6(y)-259.2(h)-.1(avi)5.6(n)-.1(g)-259.2(d)-.1(ist)5.6(i)-.2(nct)-259.4(e)4.5(ffect)5.6(s)-259.1(o)-.1(n)-259.2(o)-.1(rgan)-259.2(phys)5.9(iolog)5.7(y)-.1(.)]TJ
1.0137 -1.1174 TD
-.0223 Tc
[(Cl)5.3(ear)5.4(ly,)-515.3(t)-.5(here)-519.9(i)5.3(s)-518.5(sig)5.4(n)-.4(i)5.6(can)5.4(t)-518.9(overlap)-518.7(in)-518.7(b)5.4(o)-.4(th)-513(practi)5.3(ce)-519.9(and)]TJ
-1.0137 -1.1116 TD
[(theory)-564.8(sup)5.4(por)5.4(tin)5.4(g)-570.6(a)4.2(cu)5.4(pun)5.4(ctu)5.4(r)-.3(e)-566(a)-1.5(nd)-564.8(neuro)5.4(m)-1.6(o)5.4(dul)5.3(ati)5.3(o)-.3(n.)-567.1(There)]TJ
T*
-.022 Tc
[(hav)5.7(e)-346.8(been)-339.9(a)-346.8(n)5.7(umb)5.7(e)-1.2(r)-339.8(o)-.1(f)-345.6(i)5.6(nteres)5.9(tin)5.7(g)-345.6(i)-.2(n)5.7(nov)5.7(at)5.6(ion)5.7(s)-345.4(in)-339.9(neu)5.7(r)0(omod)5.7(u-)]TJ
0 -1.1174 TD
[(lat)5.5(i)-.3(on)-501.3(t)5.5(h)-.2(at)-495.6(shou)5.6(ld)-501.3(b)5.6(e)-502.4(con)5.6(s)0(id)5.6(ered)-501.2(by)-501.2(acup)5.6(unctu)5.6(rist)5.5(s,)-503.6(s)5.8(u)-.2(ch)-495.5(as)]TJ
0 -1.1116 TD
-.0275 Tc
[(c)-6.7(l)-5.7(os)-5.4(e)-6.7(d)-495.1(l)-5.7(o).2(o)-5.6(p)-495.1(s)-5.4(t)-5.7(im)-6.8(ul)-5.7(a)-6.7(t).1(i)-5.7(o)-5.6(n,)-497.5()-5.4(e)-6.7(xi)-5.7(b)-5.6(i).1(l)-5.7(i)-5.7(t).1(y)-495.1(i)-5.7(n)-495.1(p)-5.6(u)-5.6(l).1(s)-5.4(e)-496.3(w)-6.4(a)-1(v)-5.6(e)-6.7(fo)-5.6(r)-5.5(m)-1(s)-5.4(,)-497.5(an)-5.6(d)]TJ
T*
-.0224 Tc
[(imp)5.3(l)-.6(an)5.3(ted)-259.6(s)-.3(t)5.2(i)-.6(mu)5.3(lat)5.2(o)-.5(rs)5.5(.)-262(M)-1.4(or)5.3(eov)5.3(e)-1.6(r,)-262(crit)5.2(ical)-265.5(concept)5.2(s)-265.2(p)5.3(r)-.4(omulg)5.3(a)-1.6(ted)]TJ
0 -1.1174 TD
-.0216 Tc
[(in)-316.4(th)6.1(e)-317.6(n)6.1(eur)6.1(o).3(mo)6.1(dul)6(ati)6(o).3(n)-316.4()6.3(eld)6.1(,)-318.8(s)6.3(u).3(ch)-310.7(as)-316.2()52.2()6.1(tar)6.1(g).3(et)-310.8(eng)6.1(a)-.8(g)6.1(e)-.8(me)4.9(nt,)52.2()-310.7(o).3(r)]TJ
0 -1.1116 TD
-.0222 Tc
[(the)-335.5(i)-.4(d)5.5(e)-1.4(a)-335.5(t)-.4(h)5.5(a)-1.4(t)-334.5(a)-335.5(quanti)5.4(t)-.4(at)5.4(ive)-335.5(o)-.3(u)5.5(t)-.4(come)-335.5(metr)5.5(ic)-335.5(can)-340.1(c)4.3(on)5.7(rm)-335.5(th)5.5(at)-334.5(a)]TJ
T*
-.022 Tc
[(phy)5.7(siol)5.6(ogi)5.6(cal)-495.5()51.8(target)51.8()-495.4(o)5.7(f)-495.4(s).1(ti)5.6(mul)5.6(a)-1.2(ti)5.6(on)-495.4(i)5.6(s)-495.2(act)5.6(ual)5.6(l)-.2(y)-495.4(m)4.5(odu)5.7(lat)5.6(e)-1.2(d,)]TJ
0 -1.1174 TD
-.0216 Tc
[(cou)6.1(l).2(d)-333.7(b).3(e)-334.9(i).2(m)4.9(p).3(o)6.1(r).4(ta)4.9(nt)-333.9(to)-333.7(tra)4.9(n).3(sl)6(ate)-334.9(t)6(o)-333.7(acu)6.1(pun)6.1(ctu)6.1(r).4(e)-334.9(r).4(e)4.9(s).5(ea)4.9(rch)-333.7(a)4.9(nd/)6(or)]TJ
0 -1.1116 TD
[(cli)6(n).3(ic)4.9(al)-339.6(p)6.1(r).4(ac)4.9(tic)4.9(e.)-336(In)-339.5(t)6(u).3(rn)6.1(,)-341.8(a)4.9(cup)6.1(unc)4.9(tur)6.1(e)-340.6(sc)4.9(hol)6(ars)-333.5(a)-.8(nd)-333.7(rese)4.9(ar)6.1(che)4.9(r).4(s)]TJ
T*
-.0226 Tc
[(hav)5.1(e)-347.4(accu)5.1(mul)5(a)-1.8(ted)-346.2(b)5.1(oth)-340.5(e)-1.8(mpiri)5(c)-1.8(al)-346.4(an)5.1(d)-346.2(r)-.6(esearch)-340.5(s)-.5(up)5.1(por)5.1(t)-346.4(f)-.6(o)5.1(r)-346.2(th)5.1(e)]TJ
T*
-.0241 Tc
[(sa)-3.3(fety,)-298.2(e)2.4(fca)-3.3(cy,)-298.2(a)-3.3(nd)-301.7(me)-3.3(c)-3.3(h)3.6(a)-3.3(n)3.6(isms)-301.5(of)-295.9(c)-3.3(u)3.6(ta)-3.3(ne)-3.3(ous)-301.5(o)3.6(r)-301.6(p)-2.2(erc)-3.3(u)3.6(tane)-3.3(ous)]TJ
0 -1.1174 TD
-.0223 Tc
[(stimul)5.3(ati)5.3(o)-.4(n)-449.6(t)-.5(o)-449.6(a)-1.5(dd)5.4(res)5.6(s)-455.2(mult)5.3(ipl)5.3(e)-456.5(medi)5.3(cal)-455.5(d)5.4(isor)5.4(der)5.4(s)-.2(a)-450.8(k)5.4(nowl-)]TJ
0 -1.1116 TD
[(edg)5.5(e)-249.1(bas)5.7(e)-249.1(in)-247.9(need)-247.9(o)5.5(f)-247.9(greater)-247.9(c)-1.4(on)5.5(sid)5.5(e)-1.4(ratio)5.5(n)-247.9(b)-.3(y)-247.9(a)-249.1(br)5.5(oad)5.5(e)-1.4(r)-247.9(a)4.3(rray)-247.9(o)5.5(f)]TJ
T*
-.0214 Tc
[(bio)6.3(m)-.7(ed)6.3(ica)5.1(l)-333.7(r)6.3(e)-.6(se)5.1(arc)5.1(h).5(er)6.3(s)-333.3(a)5.1(nd)-333.5(o)6.3(u).5(r)-327.7(h).5(ea)5.1(lth)6.3(car)6.3(e)-334.7(s)6.5(yste)5.1(m.)]TJ
1.0137 -1.1174 TD
0 Tc
[(In)-480.2(summary,)-481.1(whether)-477.5(acupuncture)-483.4(is)-480.2(a)-474.6(form)-477.9(of)-480.2(neuro-)]TJ
-1.0137 -1.1116 TD
[(modulation)-301.8(may)-305.2(be)-297.1(simply)-301.6(asking)-301.4(whether)-299(a)-301.8()50.8(white)-302.6(horse)50.1()]TJ
T*
[(is)-238.3(a)-238.4()50.8(horse)43.3()-237.2(i)0(n)-232.7(the)-240.7(ancient)-241.9(Chinese)-241.4(white)-238.2(horse)-236.8(paradox.)-238.1(For)]TJ
0 -1.1174 TD
[(this)-252.1(example,)-252.1(the)-246.5(white)-249.7(horse)-254.1(may)-247.6(indeed)-251(be)-251(a)-244.2(horse,)-251.8(and)-246.4(we)]TJ
0 -1.1116 TD
[(should)-548(embrace)-543.5(this)-545.9(overlap)-545.8(to)-543.7(further)-544.6(research)-548.9(in)-543.7(both)]TJ
T*
[(elds,)-372.7(rather)-371.9(than)-374.3(turning)-370.8(a)-370.9(blind)-368.6(eye)-374.2(and)-367.3(needing)-373(to)-370.9(rein-)]TJ
0 -1.1174 TD
[(vent)-443.4(the)-436.6(wheel)-440.8(in)-440.1(research)-445.2(design)-439.7(and)-442.2(evaluation)-441.1(of)-439.9(both)]TJ
0 -1.1116 TD
[(acupu)-7.8(ncture)-331.6(and)-338.5(neuromodulation)-337.2(therapies.)]TJ
ET
q
1 i
62.022 71.546 m
301.153 71.546 l
301.153 56.58 l
62.022 56.58 l
W n
0 0 0 RG
1 J 1 j .227 w 10 M []0 d
q 1 0 0 1 13.89 71.546 cm 0 0 m
120.359 0 l
S
Q
Q
BT
8.9663 0 0 8.9663 70.9795 56.5795 Tm
[(*\(https://commonfund.nih.gov)105.9(/)110.3(sparc\).)]TJ
/F11 1 Tf
-.999 77.2976 TD
(622)Tj
49.3946 0 TD
(NAPADOW)Tj
ET
endstream
endobj
23 0 obj
<>stream
h,=N0 F
(p&HD&vةIS;IE#gV}Xk6ðN:LJ'{gWQ7uW?ogzi/kgH@d.. nQ*YjE!yg,KiNi5RUȢ{w_s$
Pc)
"YxT
)+TQR/ٌ?(b>C䢈xGNLlunu1d(S8(1R4d` ㇟
endstream
endobj
26 0 obj
<>stream
/GS1 gs
BT
/F13 1 Tf
8.9663 0 0 8.9663 59.7543 725.7825 Tm
0 0 0 rg
0 Tc
0 Tw
[(Author)-338.3(Disclosure)-338.2(Statement)]TJ
/F5 1 Tf
9.843 0 0 9.843 69.7323 709.3416 Tm
[(Financial)-589.6(interests)-593.9(include)-586.3(GlaxoSmithKline)-10.8(,)-585.2(Inc.)-583.8(and)]TJ
-1.0137 -1.1116 TD
[(neuroPhase,)-340.1(Inc.)]TJ
/F13 1 Tf
8.9663 0 0 8.9663 59.7543 676.4597 Tm
(References)Tj
/F5 1 Tf
9.2951 0 0 9.2951 64.4031 660.4155 Tm
[(1.)-500.4(Longzi)-329.7(G.)-325.1(On)-325.1(the)-327.3(white)-328.6(horse.)-329.7(In:)-325.4(Ivanhoe)-328.9(P,)-320.3(Van)-329.5(Norden)]TJ
1.2503 -1.1283 TD
.0129 Tc
[(B,)-505.6(eds)-4.6(.)-505.6(Read)-5.5(in)-5.5(gs)-504.8(i)-5(n)-505.7(Cl)-5(ass)-4.6(i)-5(cal)-505.1(C)-4.2(h)-5.5(i)1.1(n)-5.5(e)-3.6(se)-509.9(Ph)-5.5(il)-5(os)-4.7(o)-5.5(phy)-5.5(.)-505.6(I)-1.8(n-)]TJ
0 -1.1223 TD
[(d)-5.5(i)1.1(an)-5.5(ap)-5.5(ol)-5(is)-4.7(,)-334.8(I)-1.8(N)-7.1(:)-334.3(Hacket)-5(t)-334.3(P)-2.3(ub)-5.5(li)-5(s)-4.6(h).6(i)-5(ng,)-340.9(200)-5.5(5:)-5(36)-5.5(3)-5.5(368)-5.5(.)]TJ
-1.2503 -1.1284 TD
0 Tc
[(2.)-500.4(MacPherson)-560.5(H,)-556.8(Hammerschlag)-556.9(R,)-553.9(Coeytaux)-556.6(RR,)-558.9(et)-552.9(al.)]TJ
1.2503 -1.1223 TD
[(Unanticipated)-365.7(insights)-363.6(into)-359.3(biomedicine)-359.7(from)-364.6(the)-357.8(study)-359.1(of)]TJ
0 -1.1284 TD
[(acupuncture.)-313(J)-310.3(Altern)-306.7(Complement)-311.5(Med)-308.9(2016;22:101107.)]TJ
-1.2503 -1.1223 TD
[(3.)-500.4(Koehler)-397(PJ,)-392.7(Finger)-394(S,)-393.5(Piccolino)-395.1(M.)-389.8(The)-396.9()58.5(Eels)50.9()-392.8(o)0(f)-393(South)]TJ
1.2503 -1.1284 TD
[(America:)-589.4(Mid-18th-Century)-589.1(Dutch)-585.4(Contributions)-585.2(to)-585.2(the)]TJ
0 -1.1223 TD
[(Theory)-247.2(of)-240.5(Animal)-242.9(Electricity.)-247.4(J)-243.2(Hist)-244.1(Biol)-242.1(2009;42:715763.)]TJ
-1.2503 -1.1284 TD
[(4.)-500.4(Famm)-263(K,)-264.1(Litt)-263(B,)-261.2(Tracey)-261.7(KJ,)-263.3(et)-260.1(al.)-266.3(Drug)-260.6(discovery:)-266.3(A)-257.9(jump-)]TJ
1.2503 -1.1223 TD
[(start)-334.6(for)-334.4(electroceuticals.)-341.5(Nature)-335.9(2013;496:159161.)]TJ
-1.2503 -1.1284 TD
[(5.)-500.4(Langevin)-425.6(HM,)-428.1(Schnyer)-423.3(R,)-425.8(MacPherson)-426.3(H,)-428.7(et)-424.8(al.)-424.8(Manual)]TJ
1.2503 -1.1223 TD
[(and)-395(electrical)-400.7(needle)-403.3(stimulation)-398.1(in)-390.1(acupuncture)-404.4(research:)]TJ
0 -1.1284 TD
[(Pitfalls)-348.9(and)-352.3(challenges)-351.7(of)-350.3(heterogeneity.)-348.8(J)-346.9(Altern)-349.4(Comple-)]TJ
T*
[(ment)-339.2(Med)-333.3(2015;21:113128.)]TJ
-1.2503 -1.1223 TD
-.0152 Tc
[(6)-15.2(.)-515.6(Fr)-15.2(a)8.5(n)3(cis)-313.3(R)-1.8(P,)-314.1(Jo)-15.2(h)8.9(n)3(son)-314.2(M)-2.4(I.)-314.1(Th)-15.2(e)-300.3(c)-1.2(h)-15.2(a)10.8(racteristics)-313.3(o)3(f)-316.5(acup)-15.2(u)15(n)-15.2(c)10.8(ture-)]TJ
1.2503 -1.1284 TD
-.0138 Tc
[(lik)4.4(e)-268.2(t)4.9(ran)-13.8(s)11.2(cu)4.4(tan)4.4(e).2(o)-13.8(u)16.4(s)-263.1(e).2(lectri)4.9(cal)-269.5(n)4.4(e).2(rv)-13.8(e)-250.1(s)-.9(ti)4.9(mu)4.4(lati)4.9(o)-13.8(n)-252(\(acu)4.4(p)-13.8(u)16.4(n)-13.8(c)12.2(tu)4.4(re-)]TJ
0 -1.1223 TD
0 Tc
[(li)19.2(ke)-364.3(TE)20.3(NS)25.7(\):)-361.9(A)-373.8(l)12.6(it)19.2(er)17.6(a)14(t)0(u)18.6(r)0(e)-360.6(r)0(e)17.6(v)0(i)24.7(e)0(w)18.3(.)-372.1(Ac)18.3(up)24.1(un)18(c)14(t)-371.6(El)16.7(e)14(c)0(t)14.4(r)15.8(ot)18.6(he)19.9(r)-368.4(R)0(e)15.1(s)]TJ
0 -1.1284 TD
[(20)18(11)24.1(;3)18.6(6:)24.7(23)18(1)24.1(25)18(8.)]TJ
-1.2503 -1.1223 TD
[(7.)-500.4(Langevin)-261(HM,)-257.4(Wayne)-257.5(PM.)-258.7(What)-258.6(is)-255(the)-260.2(point?)-260.1(The)-256.6(problem)]TJ
1.2503 -1.1284 TD
[(with)-251.1(acupuncture)-258(research)-253.5(that)-247.6(no)-250.4(one)-248.6(wants)-255.1(to)-249.8(talk)-247.6(about.)-254.5(J)]TJ
0 -1.1223 TD
[(Altern)-337.2(Complement)-335.9(Med)-333.3(2018;24:200207.)]TJ
-1.2503 -1.1284 TD
[(8.)-500.4(Britton)-378.4(TC,)-379.1(Thompson)-373.8(PD,)-376.9(Day)-378.3(BL,)-379.1(et)-376(al.)-376(Modulation)-375.3(of)]TJ
1.2503 -1.1223 TD
[(postural)-481.4(tremors)-477.6(at)-479.7(the)-479.8(wrist)-478.3(by)-476(supramaximal)-483.4(electrical)]TJ
0 -1.1284 TD
[(m)12.5(e)14(d)18.2(i)12.6(a)14(n)-280.7(n)18.2(e)14(rv)27.9(e)-284.9(s)19(ho)30.2(c)14(k)0(s)-267.8(i)12.6(n)-280.7(e)20.1(s)12.9(s)12.9(e)14(n)18.2(t)12.6(i)12.6(a)14(l)-280.1(t)18.7(re)23.7(m)18.6(o)0(r)27.9(,)-280.6(P)15.3(a)14(r)15.8(k)0(i)30.8(n)0(s)25(o)18.2(n)27.9(s)-279.8(d)18.2(i)12.6(s)12.9(e)14(a)14(s)19(e)]TJ
0 -1.1223 TD
[(a)14(n)0(d)-329.6(n)0(o)30.2(r)15.8(m)12.5(a)14(l)-341.1(s)12.9(u)18.2(b)0(j)24.7(e)14(c)14(t)18.7(s)-346.9(m)18.6(i)12.6(m)12.5(i)18.7(c)14(ki)30.8(ng)-329.6(t)12.6(r)15.8(e)14(m)12.5(o)18.2(r)15.8(.)-347.7(J)-340.8(N)16.6(e)14(ur)27.9(ol)-329.1(N)16.6(e)14(ur)27.9(o)18.2(s)12.9(ur)27.9(g)]TJ
0 -1.1284 TD
[(P)15.3(s)12.9(yc)26(h)18.2(i)12.6(a)14(t)18.7(ry)-307.6(1)18.2(9)0(9)30.2(3)0(;)30.8(5)0(6)24.1(:)18.7(10)30.2(85)30.2(1)30.2(08)30.2(9.)]TJ
-1.2503 -1.1223 TD
[(9.)-500.4(Zhao)-305.5(Q,)-306.8(Zhang)-299.6(S,)-302(Zhao)-305.5(H,)-306.8(et)-302.8(al.)-302.9(Median)-306.8(nerve)-304.2(stimulation)]TJ
1.2503 -1.1284 TD
[(prevents)-278.8(atrial)-278.2(electrical)-278.7(remodelling)-278.5(and)-279.1(inammation)-272.6(in)-274.2(a)]TJ
0 -1.1223 TD
[(canine)-385(model)-376(with)-379.2(rapid)-378.7(atrial)-381.9(pacing.)-374.7(Europace)-383.9(2018;20:)]TJ
0 -1.1284 TD
(712718.)Tj
-1.7505 -1.1223 TD
[(10.)-500.5(Zhao)-329.9(S,)-326.4(Tang)-323.8(M,)-328.8(Yuan)-323.5(K,)-331.2(et)-327.2(al.)-321.2(Median)-331.2(nerve)-328.6(stimulation)]TJ
1.7505 -1.1284 TD
[(reduces)-533.5(ventricular)-529.5(arrhythmias)-530.6(induced)-527.3(by)-524.8(dorsomedial)]TJ
0 -1.1223 TD
[(hy)30.2(po)30.2(t)12.6(h)0(a)26(l)18.7(a)14(m)12.5(i)18.7(c)-266.6(s)12.9(t)18.7(i)12.6(m)12.5(u)18.2(l)12.6(a)14(t)18.7(i)12.6(o)0(n)30.2(.)-262.3(J)-261.5(I)15.8(nt)24.7(e)14(r)15.8(v)-262.4(C)13.4(a)14(r)15.8(d)-262.4(E)16.3(l)12.6(e)14(c)14(t)18.7(ro)27.9(ph)30.2(ys)31.1(i)12.6(o)0(l)-249.8(2)18.2(01)30.2(6;)]TJ
0 -1.1284 TD
-.0302 Tc
[(4)-30.2(7)0(:)-17.6(2)-30.2(75)-30.2(2)-30.2(83)-30.2(.)]TJ
-1.7505 -1.1223 TD
-.0243 Tc
[(1)-24.3(1)-24.3(.)-524.8(Li)-237.3(P,)-237.8(Lon)6.1(ghurst)-237.3(JC.)-237.8(N)4.5(eural)-237.3(m).4(echanism)-237.5(of)-234.1(electroacu)6.1(punctures)]TJ
1.7505 -1.1284 TD
-.0245 Tc
[(hypotensive)-333.8(effects.)-335.6(Au)5.9(ton)-335.7(N)-1.8(eurosci)-329(2010;157)5.9(:)-5.8(2)5.9(430.)]TJ
25.263 47.4825 TD
0 Tc
[(12.)-500.5(Ng)-294.6(FL,)-297.9(Saxena)-296.9(M,)-298.3(Mahfoud)-293.5(F,)-295.9(et)-296.7(al.)-296.8(Device-based)-305.8(therapy)]TJ
1.7505 -1.1223 TD
[(for)-334.4(hypertension.)-333.8(Curr)-333.3(Hypertens)-335.4(Rep)-338.8(2016;18:61.)]TJ
-1.7505 -1.1284 TD
[(13.)-500.5(Maeda)-372.5(Y,)-367.8(Kim)-373.1(H,)-373.8(Kettner)-372(N,)-373.8(et)-369.9(al.)-369.9(Rewiring)-372.8(the)-370(primary)]TJ
1.7505 -1.1223 TD
[(so)12.8(mat)14.7(osen)14.4(so)12.8(ry)-356.4(cor)17.4(tex)-351.7(in)-353.5(car)13.2(pal)-351.7(tun)12.3(ne)13.8(l)-359.4(syn)12.7(dro)15.5(me)-357.8(wit)17.4(h)-360(acu-)]TJ
0 -1.1283 TD
[(pun)17.9(ctu)14.2(re.)-324(Bra)18.8(in,)-323(201)17.9(7:1)12.3(40:)18.4(914)17.7(927.)]TJ
-1.7505 -1.1223 TD
[(14.)-500.5(de)-321.7(Wall)-325.1(LL,)-321.3(Heesakkers)-331.5(JP.)-319.5(Effectiveness)-327.3(of)-325.9(percutaneous)]TJ
1.7505 -1.1284 TD
[(tibial)-618.8(nerve)-615.3(stimulation)-623.7(in)-615.7(the)-614(treatment)-624(of)-618.6(overactive)]TJ
0 -1.1223 TD
[(bladder)-334.4(syndrome.)-335.8(Res)-331.8(Rep)-338.8(Urol)-333.3(2017;9:145157.)]TJ
-1.7505 -1.1284 TD
[(15.)-500.5(Finazzi-Agro)]TJ
6.6787 .0427 TD
(`)Tj
.8661 -.0427 TD
[(E,)-459.5(Petta)-456.1(F,)-454.5(Sciobica)-460.8(F,)-454.5(et)-455.3(al.)-455.3(Percutaneous)]TJ
-5.7943 -1.1223 TD
[(tibial)-563.9(nerve)-566.5(stimulation)-568.8(effects)-571.8(on)-561.4(detrusor)-569.7(overactivity)]TJ
0 -1.1284 TD
[(incontinence)-254.7(are)-249(not)-249.9(due)-248.6(to)-249.8(a)-254.4(placebo)-250.9(effect:)-255(A)-245.7(randomized,)]TJ
0 -1.1223 TD
.0254 Tc
[(dou)-5.2(bl)-4.7(e-)-7.6(bli)-4.7(n).9(d)-5.2(,)-322.3(pl)-4.7(aceb)-5.2(o)-322.4(c)-3.3(ont)-4.7(rol)-4.7(l)1.4(ed)-322.4(t)-4.7(r)-1.5(ial)-4.7(.)-322.3(J)-321.5(U)-.7(ro)-5.2(l)-321.8(2).9(0)-5.2(1).9(0)-5.2(;)1.4(18)-5.2(4:)]TJ
0 -1.1284 TD
.0245 Tc
[(200)-6.1(1)-6.1(200)-6.1(6.)]TJ
-1.7505 -1.1284 TD
0 Tc
[(16.)-500.5(Zhao)-329.9(Y,)-325.1(Zhou)-331.8(J,)-328.7(Mo)-328.9(Q,)-325.1(et)-333.3(al.)-327.3(Acupuncture)-334.7(for)-328.3(adults)-326.3(with)]TJ
1.7505 -1.1223 TD
[(overactive)-306.1(bladder:)-309.6(A)-312.8(systematic)-309(review)-311.5(and)-303.5(meta-analysis)]TJ
0 -1.1284 TD
[(of)-246.6(ran)11.3(dom)12.2(ize)16.1(d)-256.3(con)13.7(tro)16.1(lled)-247.6(tri)16.7(als)15.1(.)-256.2(Med)14.4(icin)14.7(e)-254.4(\(Ba)12.7(lti)13.5(mo)12.3(re\))-253.2(201)17.9(8;)]TJ
0 -1.1223 TD
[(97:)18.4(e98)13.7(38.)]TJ
-1.7505 -1.1284 TD
[(17.)-500.5(Yuan)-530.9(H,)-526.3(Silberstein)-536.6(SD.)-529.4(Vagus)-530.2(nerve)-529.9(and)-529.2(vagus)-534.7(nerve)]TJ
1.7505 -1.1223 TD
.0116 Tc
[(st)11.6(i)-5.8(m)-.3(ulatio)5.4(n,)-391(a)-389.2(c)1.2(omp)5.4(r)-3.1(ehen)5.4(si)]TJ
11.3751 0 TD
.0108 Tc
[(ve)-390(re)-5.7(view:)-391.3(P)1.7(art)-385.2(I)-3.9(II.)-391.8(Headache)]TJ
-11.3751 -1.1284 TD
.0123 Tc
[(2)6.1(016;)12.3(5)-5.7(6)0(:47)6.1(94)6.1(90.)]TJ
-1.7505 -1.1223 TD
-.0201 Tc
[(1)-20.1(8)-20.1(.)-520.6(M)4.9(u)-1.9(rray)-294.7(A)-3.5(R,)-294.6(Atk)4.2(i)-1.4(ns)5(on)-294.7(L,)-294.6(Mahad)4.2(i)-294.1(MK,)-300.7(e)0(t)-294.1(a)0(l)4.7(.)-300.7(Th)4.2(e)-298.9(s)-1.1(t)4.7(r)-4.3(an)4.2(ge)-292.8(case)]TJ
1.7505 -1.1284 TD
-.0207 Tc
[(of)-419.6(the)-421.5(ear)-419.6(and)-423.4(t)4.1(he)-415.4(heart:)-416.7(The)-421.5(a)-.6(uricular)-419.6(vagus)-416.4(n)-2.5(erve)-421.5(and)-417.3(i)4.1(ts)]TJ
0 -1.1223 TD
-.0214 Tc
[(inuence)-245.3(on)-247.2(cardiac)-245.3(control.)-247.1(Au)]TJ
12.3022 0 TD
-.0184 Tc
[(to)5.9(n)-244.2(N)4.3(eu)5.9(ro)5.9(sci)-243.6(2)5.9(01)5.9(6;)6.4(19)5.9(9:4)5.9(8)-.2()5.9(5)-.2(3)5.9(.)]TJ
-14.0526 -1.1284 TD
-.0162 Tc
[(1)-16.2(9)-16.2(.)-516.7(F)5.2(r)-.4(k)-16.2(j)14.6(a)3.8(er)-238.2(JB,)-235.8(B)3.3(ergmann)-235.9(S)-.9(,)-235.8(B)-2.8(r)5.7(o)-16.2(c)15.9(k)-235.9(C,)-235.8(et)-235.3(al.)-235.8(M)2.7(od)-16.2(u)14(l)2.5(ation)-242(o)2(f)-238.2(v)2(a)3.9(g)-16.2(a)15.9(l)]TJ
1.7505 -1.1223 TD
-.0176 Tc
[(tone)-418.4(enh)-17.6(a)14.5(nces)-413.3(gas)-4.7(t)1.1(roduo)-17.6(d)12.6(e)2.5(n)-17.6(a)14.5(l)-413.6(m)-5.1(otil)-5(ity)-414.2(and)-414.2(r)-1.8(educes)-413.3(som)-5.1(a)2.5(t)-5(i)1.1(c)]TJ
0 -1.1284 TD
-.0181 Tc
[(pai)-5.5(n)-335.4(sensit)-5.5(ivit)-5.5(y.)-335.3(Neu)-18.1(r)15.9(o)-18.1(g)12.1(as)-5.2(troenterol)-334.8(Mot)-5.5(i).6(l)-334.8(2016;)-5.5(28:5)-18.1(9)12.1(2598)-18.1(.)]TJ
-1.7505 -1.1223 TD
0 Tc
[(20.)-500.5(Alimi)-414.9(D,)-410.4(Chelly)-417.4(JE.)-416.1(New)-416.4(universal)-412.6(nomenclature)-421.9(in)-414.5(aur-)]TJ
1.7505 -1.1284 TD
[(iculotherapy.)-332.2(J)-334.7(Altern)-337.2(Complement)-335.9(Med)-333.3(2018;24:714.)]TJ
-1.7505 -1.1223 TD
[(21.)-500.5(Garcia)-346.2(RG,)-342.2(Lin)-337.2(RL,)-342.5(Lee)-346.2(J,)-340.9(et)-345.5(al.)-339.5(Modulation)-344.8(of)-338.1(brainstem)]TJ
1.7505 -1.1284 TD
[(activity)-623.3(and)-620.7(connectivity)-628.1(by)-622.4(respiratory-gated)-629.8(auricular)]TJ
0 -1.1223 TD
[(vagal)-344(afferent)-349.5(nerve)-346.9(stimulation)-349.3(in)-341.3(migraine)-345.8(patients.)-348.6(Pain)]TJ
0 -1.1284 TD
(2017;158:14611472.)Tj
9.843 0 0 9.843 438.803 381.4298 Tm
[(Address)-331.9(correspondence)-343.5(to:)]TJ
/F6 1 Tf
.1037 -1.1116 TD
[(Vitaly)-331.9(Napadow,)-335.8(PhD,)-337.1(LAc)]TJ
-9.7454 -1.1116 TD
[(Center)-338.2(for)-337.3(Integrative)-338.3(Pain)-334(NeuroImaging)-338.7(\(CiPNI\))]TJ
4.1297 -1.1174 TD
[(Martinos)-332.3(Center)-338.2(for)-337.3(Biomedical)-332.6(Imaging)]TJ
3.571 -1.1116 TD
[(Massachusetts)-339.7(General)-339.1(Hospital)]TJ
3.1045 -1.1116 TD
[(Harvard)-337.7(Medical)-333.9(School)]TJ
-.9676 -1.1174 TD
[(CNY)-333.5(149-2301,)-334.8(13th)-332.8(Street)]TJ
1.1116 -1.1116 TD
[(Charlestown)-9.5(,)-331.7(M)0(A)-332.8(02129)]TJ
-3.4155 -2.1253 TD
(E-mail:)Tj
/F5 1 Tf
3.3982 0 TD
(vitaly@mgh.harvard.edu)Tj
/F11 1 Tf
8.9663 0 0 8.9663 59.7543 749.7069 Tm
[(SAR)-338.6(TURNING)-333.3(POINTS)]TJ
53.0113 0 TD
(623)Tj
ET
endstream
endobj
30 0 obj
<>stream
h M![%j)aEURLID&+cu"U-ٕT+U1xD" %!
B{RIE)RtEZ|RZ#i)bAGH$vD5jM, DcgIwcrjNcV-VֻKX>Wkrn)pqq_) x3
bG{Nމymjݹ1pbX{\Ҍ9~ێ\1j39Mn0*C9Y;pW,f{*
GG3.GldíoYñ]B_wճ0#g06_&G) }i.=>!໗@3߹6t'=]gf
=R=uXv#f(=Uvc i~
q|9`~[d$}-e^?U,t^1.d+)XI\cϸB}RJ2L}Ӧ'-5Ka W,NA?'|[щ(:9l
d*kڐUqFCSl`a/^3*+*/6h?y$ҿONH@r̶ȹipFMƙ|xt0./XEw2-;p!XVsRh77Z%g*E21,`WždgîoŞA4OÓ4,o"2Kz隲3BseSg?p1ualnmB0kf]bjtAfgkn=@ų@>kjOWo4fdN[#B)]98eO8XXI=7$!v?OYb˫K7j#S~,NThCLYnᴽywxsaiMЅ&qsC]PF5UQmm=|#}Hߞ?lnĪvknSq$Sٞ&ZrGފ
C5|Ѷ)@a&s]e:_wPPbCsYx?]hI0g}(u;bdy j
endstream
endobj
32 0 obj
<>stream
hTn0E{bʍRn$(En{X
23d|3{s<^p'8hYJKF:{;OyisnSVܧw^B KIX#)4
(>"Feѓ
NYX5FKK$V)}HQ"I~ĶʩEy]Gk)N Z|m?${E.Q^%l<=Ɇ'`
endstream
endobj
34 0 obj
<>stream
8;X]O>EqN@%''O_@%e@?J;%+8(9e>X=MR6S?i^YgA3=].HDXF.R$lIL@"pJ+EP(%0
b]6ajmNZn*!='OQZeQ^Y*,=]?C.B+\Ulg9dhD*"iC[;*=3`oP1[!S^)?1)IZ4dup`
E1r!/,*0[*9.aFIR2&b-C#soRZ7Dl%MLY\.?d>Mn
6%Q2oYfNRF$$+ON<+]RUJmC0InDZ4OTs0S!saG>GGKUlQ*Q?45:CI&4J'_2j$XKrcYp0n+Xl_nU*O(
l[$6Nn+Z_Nq0]s7hs]`XX1nZ8&94a\~>
endstream
endobj
36 0 obj
<>stream
8;Z]"%@2Vh%"u/emZ[P/527O;f`]]#jB#_nq])4YCYR/Q5`EpJ0$'OsSQ^5O+sqN\
#3C:'i@3*Y_Qj!q'8sK^cu)Qp'n!CheW]bOlaDP+Q[M$n7[7k`\j#N\k-@p"`"qKo
#Yq(0!XD-ED$h+Co?gj?$]T)7Q=!,j+3cuMY]L&(l>q0K9X+DQ5.1.7@Ec*[dN-']
eoA]_T:2e!N2P=sof;E1JVO>5u1ikh-XEsG(7L=
-2q^d\-8o*5o6SJU4Ym*AE@CQP1'sMV,k!);$&$`oVEi+AT?@h7!+p0)YU$+j[8$p
01+i\!0CUD(P"c@J2k8%\UDWB3.b=#&:^uuMirg//1gJ$bq9k"0@]u!i"e-3X,3YY
feoM"V%fu`(H@RMqu0R5ojsqYV'J']c?fNr;f=N'X0hA,_Ca+/J,5-=?`1X>!#7Y=ir~>
endstream
endobj
15 0 obj
<>stream
8;Z\76#smd%-.@0oQN@`Ccbe(,hl]:Sb7hm+A7TEM:j7+0h-09G9#bn'uLD`#(G@i
[1Wl[94L,'+^W>IPffjnmMKQsC8JH)=0o7V00W1:\9gLmYfPTC_Vtb>o]p.:b@kEA
&(_Wp,]aaNrN]QCd/S;OW%hi!/WnEA&23SCCIoF[l97,I2q6]#,9"7-+>a]^1bGuN
7Y@rqY3bs!,GRY;6uj?NIaR7./$(8:M^sB$ieGJ*11@=.\7C7X-D`
$\6gPAf:Dk5g=X_CCprua4r'G:Z$-bV'Xb-S5mc.hH[$;X:R$3s.E_BWU@+*`c"Y*
s)(sQG5Y
endstream
endobj
27 0 obj
<>stream
8;Z\7>8"e,#jhLCaE=#X25LGm6;m,/m$D4DI5IT0'b]./]O-=VH]+]]fEAd,C&uE(
GUQM5cA/Z[CRcb/21NQ9\'`O"Z#nfkQf#Q!QKJk]%6YVrk7mhf?9>De:)aXa=hX02
P=FliMFl=bPGh<_G7kLT^l!]$(F0LU3Y_&pG]q/=^nS@lGB66.`2C%jFiR*@gR2=Lk*'isIW@L-d
c7qS\hg6WPn0'7MMdUITi*dEfNhpmk6mk%*dBKHQ=+o4#C"<*1g?2U/e$^l\?f
\>A.E.PP,U'6JR)W$^#p
endstream
endobj
40 0 obj
<>
endobj
41 0 obj
<>stream
/GS1 gs
BT
/F1 1 Tf
9.9626 0 0 9.9626 59.7543 667.9557 Tm
0 0 0 rg
0 Tc
0 Tw
[(SAR)-341.6(TURNI)-8.4(NG)-335.7(POINTS)]TJ
ET
173.31 667.672 376.611 .73706 re
f
q
1 i
59.754 630.368 m
178.696 630.368 l
178.696 583.994 l
59.754 583.994 l
W n
q
118.983 0 0 46.375 59.754 583.994 cm
/Im1 Do
Q
Q
BT
/F2 1 Tf
18.9289 0 0 18.9289 59.7543 537.2786 Tm
[(When)-335.3(a)-334.6(White)-335.2(Horse)-334.3(is)-333.3(a)-334.6(Horse:)]TJ
0 -1.1561 TD
[(Embracing)-338.7(the)-333.1(\(Obvious?\))-335.7(Overlap)]TJ
0 -1.1591 TD
[(Between)-337.1(Acupuncture)-338.1(and)-332.7(Neuromodulation)]TJ
/F3 1 Tf
11.9551 0 0 11.9551 59.7543 460.5731 Tm
[(Vitaly)-340.9(Napadow,)-338.7(PhD,)-333.5(LAc)]TJ
/F4 1 Tf
9.843 0 0 9.843 59.7543 425.8204 Tm
[(Editors)-326.5(Note:)]TJ
/F5 1 Tf
6.2608 0 TD
[(This)-322.3(column)-320.2(is)-318.9(another)-326.9(in)-319.1(our)-320.1(continuing)-323.6(series)-325.4(from)-322.3(the)-321.4(Society)-321.2(for)-320(Acupuncture)-327.6(Research)-325.3(\(SAR\).)-321.6(Vitaly)]TJ
-6.2608 -1.1116 TD
[(Napadow,)-366.6(PhD,)-364.6(LAc,)-367.1(copresident)-361.2(of)-365(the)-361.7(SAR)-362.1(Board)-364.8(of)-365(Directors,)-367.9(is)-359.2(also)-362.6(the)-367.5(Director)-363.5(of)-365(the)-361.7(Center)-367.2(for)-360.3(Integrative)-367.3(Pain)]TJ
0 -1.1174 TD
[(NeuroImaging)-351.8(\(CiPNI\))-349.3(and)-350(associate)-354.3(professor)-350.4(at)-343.3(the)-350.2(Martinos)-350.7(Center)-349.9(for)-348.8(Biomedical)-351.2(Imaging)-350(at)-343.3(Massachuset)-11.5(ts)-347.7(General)]TJ
0 -1.1116 TD
[(Hospital,)-250.6(Harvard)-247(Medical)-242.8(School.)-247.3(In)-244.1(this)-240.6(commentary,)-250.9(Napadow)-247.9(expands)-240.2(on)-244.1(a)-244.2(theme)-245.3(engaged)-247.3(in)-244.2(2016)]TJ
/F6 1 Tf
41.5966 0 TD
(JACM)Tj
/F5 1 Tf
2.805 0 TD
[(by)-244.1(SAR)-247(in)-244.2(an)]TJ
-44.4016 -1.1116 TD
[(article)-311.1(entitled)-305.4()50.8(Unanticipated)-309.4(Insights)-308.2(into)-304.2(Biomedicine)-306.2(from)-305.1(the)-304.1(Study)-305(of)-301.7(Acupuncture)45.7()-306.3(\(see)-306(his)-302.7(second)-308.2(reference\).)-308.1(The)]TJ
0 -1.1174 TD
[(exploration)-394.9(here)-392.6(is)-388(bidirection)-9.2(alhighlighting)-388.2(the)-396.2(rich)-391.6(intersection)-391.4(between)-392.3(electroacu)-11.3(puncture)-391.4(and)-390.4(that)-391.7(of)-388.1(neuromodu-)]TJ
0 -1.1116 TD
[(lation)-336.5(device)-338.5(therapy,)-336.1(a)-330.6(relatively)-337.5(new)-339.4(growth)-330.1(area)-336.2(in)-336.4(modern)-337.3(biomedicine.)-337.5()]TJ
/F6 1 Tf
32.335 0 TD
[(John)-333.9(Weeks,)-341.6(Editor-in-Chief)]TJ
/F7 1 Tf
11.9551 0 0 11.9551 205.2283 273.6566 Tm
[(Vitaly)-336.6(Napadow,)-338.4(PhD,)-336.7(LAc)]TJ
/F6 1 Tf
9.9626 0 0 9.9626 205.2283 262.2047 Tm
[(Cente)-9.2(r)-332(for)-336.3(Integrat)-10.9(ive)-333(Pa)-7(in)-334.3(NeuroI)-8.5(maging)-341.3(\(CiPNI\))]TJ
0 -1.104 TD
[(Marti)-7.6(nos)-333.5(Cente)-9.2(r)-332(for)-336.3(Biom)-9.6(edical)-338(Imagin)-7.6(g)]TJ
0 -1.0983 TD
[(Mass)-8.2(achusetts)-342.7(General)-341.2(Hospit)-9.5(al)]TJ
T*
[(Harvard)-343.5(Medical)-341.5(School)]TJ
0 -1.104 TD
[(Charle)-9.3(stown,)-337.2(Mass)-8.2(achusetts)]TJ
/F7 1 Tf
26.1167 0 0 26.1167 58.7905 133.455 Tm
(T)Tj
/F8 1 Tf
9.843 0 0 9.843 77.159 144.2834 Tm
[(here)-477.9(is)-480.2(a)-479(well-known)-482.1(logic)-483.4(paradox)]TJ
/F5 1 Tf
18.0336 0 TD
[(in)-480.4(Chinese)]TJ
-18.0336 -1.1116 TD
[(philosophy)-287.6(dating)-290.3(back)-289(more)-289(than)-293.7(2000)-286.6(years)-289.8(that)-293.8(basi-)]TJ
-1.7682 -1.1174 TD
[(cally)-238.5(suggests)-239.9(that)-236.2(a)-238.4(white)-238.2(horse)-236.8(is)-232.5(not)-239.6(a)-232.6(horse)-242.6(due)-234.9(to)-232.7(the)-240.7(fact)]TJ
0 -1.1116 TD
[(that)-265(a)-261.4()50.8(white)-262.3(horse)44.3()-260.2(i)0(s)-261.3(a)-261.4(member)-264.8(of)-261.4(two)-263.5(classes,)-261.8(both)-263.7(shape)]TJ
T*
[(\(i.e.,)-469.9(horse\))-468.3(and)-465.2(color)-467.5(\(i.e.,)-464.1(white\),)-467.3(while)-468.6(a)-468.8()50.8(horse)49()-467.6(i)0(s)-462.9(a)]TJ
0 -1.1174 TD
[(member)-247.5(of)-238.3(only)-240.7(a)-244.2(single)-238.2(class:)-245(shape.)]TJ
7.3823 0 0 6.5614 206.9857 93.8834 Tm
(1)Tj
9.843 0 0 9.843 213.0519 89.4614 Tm
[(Thus,)-239.2(a)-238.4(white)-243.9(horse)-242.6(is)]TJ
-15.5742 -1.1116 TD
[(certainly)-192.3(not)-193.5(identical)-192.5(to)-186.6(a)-186.6(horse.)-194.2(The)-190(ambiguity)-185.5(in)-192.4(the)-188.9()50.8(white)]TJ
T*
[(horse)-242.6(is)-232.5(a)-238.4(horse)50.1()-237.2(paradox)-240.4(stems)-238(from)-236(whether)-241.4(the)-235(word)-235.6()50.8(is)47.6()]TJ
T*
[(means)-285.3()50.8(is)-279.7(a)-284.5(member)-282.1(of)48.6()-277.5(o)0(r)-284.4()50.8(is)-279.7(identical)-284.6(to.)50.8()]TJ
26.5234 8.9045 TD
-.0224 Tc
[(Alt)5.2(hou)5.3(gh)-259.6(my)-259.6(go)5.3(al)-259.8(here)-260.8(i)5.2(s)-259.4(no)5.3(t)-259.8(t)-.6(o)-259.6(a)4.1(ttemp)5.3(t)-259.8(t)-.6(o)-259.6(d)5.3(en)5.3(iti)5.2(vely)-259.6(ar)5.3(gue)]TJ
-1.0137 -1.1116 TD
-.0222 Tc
[(whet)5.4(her)-426.4(a)-433.4(wh)5.5(ite)-433.4(h)5.5(o)-.3(rs)5.7(e)-433.4(i)-.4(s,)-428.8(or)-426.4(is)-432(no)5.5(t,)-428.8(a)-433.4(h)-.3(o)5.5(r)-.2(se,)-434.6(I)-432.2(d)5.5(o)-432.2(th)5.5(ink)-426.5(t)-.4(hat)]TJ
0 -1.1174 TD
-.022 Tc
[(si)5.6(mi)5.6(lar)-247.7(a)-1.2(mb)5.7(igu)5.7(ity)-247.7(exi)5.6(s).1(ts)-253.3(b)5.7(e)-1.2(tween)-253.5(a)-1.2(cupu)5.7(nct)5.6(u)-.1(re)-248.9(and)-247.7(i)-.2(nt)5.6(erv)5.7(e)-1.2(nt)5.6(ion)5.7(s)]TJ
0 -1.1116 TD
-.0224 Tc
[(enco)5.3(mp)5.3(assed)-300(b)-.5(y)-300(t)-.6(h)5.3(e)-306.9(b)5.3(r)-.4(oad)-300(c)-1.6(lass)-299.8(of)-299.9()51.4()-.4(n)5.3(e)-1.6(ur)5.3(omo)5.3(dul)5.2(ati)5.2(on,)51.4()-299.9(wh)5.3(ich)]TJ
T*
-.0213 Tc
[(i)6.3(s)-563.6(m)5.2(o).6(r)6.4(e)-559.2(bro)6.4(a)-.5(dl)6.3(y)-558(acc)5.2(ep)6.4(ted)-558(b)6.4(y)-558.1(b).6(io)6.4(med)6.4(i).5(ca)5.2(l)-558.2(r).7(e)5.2(s).8(ea)5.2(rch)-558.1(a)5.2(nd)-558.1(ou)6.4(r)]TJ
0 -1.1174 TD
-.0224 Tc
[(h)5.3(eal)5.2(thcare)-358.7(sys)5.5(t)-.6(em.)-359.9(I)-.4(s)-363.1(a)4.1(cup)5.3(u)-.5(n)5.3(c)-1.6(tu)5.3(re)-364.5(equi)5.2(val)5.2(e)-1.6(nt)-357.7(to)-357.6(neu)5.3(r)-.4(omod)5.3(ula-)]TJ
0 -1.1116 TD
-.0214 Tc
[(t)6.2(i).4(on)6.3(,)-451(o).5(r)-442.9(v).5(ic)5.1(e)-449.9(v).5(e)5.1(r).6(sa?)-444.1(W)-1.7(h)6.3(a)-.6(t)-448.8(c)5.1(an)-448.7(ac)5.1(up)6.3(unc)5.1(tur)6.3(e)-449.9(res)6.5(ear)6.3(che)5.1(r).6(s)-448.5(l).4(e)5.1(a)-.6(r)6.3(n)]TJ
T*
-.0224 Tc
[(f)5.3(r)-.4(om)-410.6(n)5.3(e)-1.6(ur)5.3(omodu)5.3(lat)5.2(i)-.6(on)-409.4(r)5.3(e)-1.6(search)-409.4(to)-409.4(better)-409.4(d)-.5(es)5.5(ign)-409.4(a)4.1(nd)-409.4(ev)5.3(alu)5.3(a)-1.6(t)5.2(e)]TJ
T*
-.0227 Tc
[(acup)5(unctur)5(e)-312.9(therap)5(ies)5.2(?)-318.7(Con)5(v)-.8(er)5(sel)4.9(y)-.8(,)-314.1(w)-1.6(h)5(a)-1.9(t)-311.9(c)-1.9(an)-311.8(neu)5(r)-.7(omodu)5(latio)5(n)]TJ
ET
59.868 180.283 .56693 157.379 re
f
192.586 180.283 .62361 157.379 re
f
59.868 337.096 133.342 .56693 re
f
59.868 180.283 133.342 .62363 re
f
q
1 i
66.444 331.087 m
186.633 331.087 l
186.633 186.86 l
66.444 186.86 l
W n
q
120.469 0 0 144.227 66.444 186.86 cm
/Im2 Do
Q
Q
BT
/F3 1 Tf
8.9663 0 0 8.9663 59.7543 749.6502 Tm
0 Tc
[(THE)-334.1(JOURNAL)-338.9(OF)-328.9(ALTERNATIVE)-341.1(AND)-333.9(COMPLEMENTARY)-339.8(MEDICINE)]TJ
/F9 1 Tf
49.8132 0 0 49.8132 431.6597 723.7982 Tm
.65 .65 .65 rg
(JACM)Tj
/F3 1 Tf
8.9663 0 0 8.9663 59.7543 739.7289 Tm
0 0 0 rg
[(Volume)-334.5(24,)-333.8(Number)-333.5(7,)-337.9(2018,)-331.8(pp.)-336.2(621623)]TJ
/F10 1 Tf
0 -1.1128 TD
()Tj
/F3 1 Tf
1.1255 0 TD
[(Mary)-331.7(Ann)-337(Liebert,)-333(Inc.)]TJ
-1.1255 -1.1128 TD
[(DOI:)-337.2(10.1089/acm.2018.29047.vtn)]TJ
/F11 1 Tf
26.5056 -76.4566 TD
(621)Tj
ET
endstream
endobj
65 0 obj
<>stream
htWiTTWC1"ܛ)J@QAQD@y**Ƣf
(yFphbp&fn;I>dwK[j_}>V&XY[[kBpɞϘbk)S2 4^.|juy˦Ԙha;p{իo'˷23 iaII%>4TW44PqjhxDBhjCRgLb8#9uChbҤTwibcBSc"ҖVfiVvVVU+ʪGji*ܪܚvmki}ل&tO0g⡉OZ6iIU0Ш
genos'뛭S&LqR9˩ʋjEM[1vړMO}{۾ow2y2c_SPԘ.K3<0;7p$Amw85V6VVX]AgʔyҬ(
N\MKlSnk/W`4eV6(X9>c#.zVdzlIsh\p+ɿCKښKJ{LbWx:>lfj~PHҼcn|/!~1#\5r[PD'm8*w"LrarWM7Bbs'-rx^qr89J4"LϥkSRS"dhXs'uR,3xZ5.35}~C0k=C!<O=<@Lɡp{r"l&PIceD6jV3} 7FլO?P3\dp> k8670ie\&J|Soܺ%d%ނ O#,'M}r@j3[J\d*[`9Ly
z0g"t7_.9Y;ǽЇ<5/vp y-SOVUh+г2B[\@e(,e6+h,rݽݛ|e;M̍?G3?9y}nFt2p0#_,ɰe {%=D?[:lAF}'ɬuΫ$8`9q" # AW|sr˰33ν0u%L||9}5L|8w\1_[Ưs==珻##R٨fǏҢ
ja.xC4
ka5
;6@>W?xիSRSeBfJB3b_4%kEu9I'՛^Ւ@՞.E!>?aE_
VSƯ_?~}69La,Sxn{ty+L%#MNfm+8Й&QE&?w2I-gr`Q)>~(0Cb3^dL*[Eb0ߌwĉz=)״x_cXg5x4ow~*__`CvU"qBQj!Tgil`F#UcI
w D,$JkbXM$+r4. t#uһRr&EQJ{!7E*PAjC?9ӣUn4,ś+XKB ~FУfu1yxgqIol`+FORNi,ՠ5CN7w81nT"促uT97x_Z:KO45 n9iBK 60-ĵ*EwHO-k-m/b`~|`qr89DWYq+B"@@Uߣ! =MKn*{F?(\AP6hVx%"ފ<}=8`S;LCN&*z28
[gvy߆?20?2rnjn3$|p!Uƺy/t~)kRt(l ?.z[8m&]i-[RԹR:?M5V=,
Kl7z<ɲ؈/2 Ҭ.U~i"~ Sj:ILB(A)l*X,+joѰ5>x:=Sk9+G=3
;۷
؛IJ ;rG'a#J>ۋfu0'Ge7֗?Y~Hq=w l%mP
(hAwG?JI(p+X}Rie?_YPHtcDj4N
Rpr7?FM$Si~S-@&^%xj
Ls-xp9 0/`39x=~)RYv`Vu;4lCy~(WW{l!
au$tzt]`0饯ƎROLټ:%?A2}gͲKMcG6hA3rۗQzRY 2gqyf>>R3`4
KS#;Soʗ8[X25Ź4C?!Cr<(;73U^fzn!:JRo|nL~0ܗy{|`lGQDikdNg`֍A(~ +gO<ܩm%-oV4_~q넻Sw,NRt_i*ڥ.=Tkac:ӃW*%$3T]yB1=fE_hT]Yv&R'
"?W[Cԧ/
% Oϱ|GȆMu } E4սNvʚ:#Pz\/T#1gмFXn |[#gۛ˰1ބZr0--$I!u|v V?T"&\EwNX{xI/xވ6-sٌuт Ko@en1]
dp%ɻfto 5`)/_x$F$on5=URhTHQ3%XraF%2V/Og"GWufpˑJDmg'~c_|l-,:V(M&{k4gUẈFpnwu+9gju'5uxf`,L`Vϭʢ"N9
;.O-.dpT3YHWZ-ei% Ĭr_Cw+H(JKR]Zs3]/NhdkS!,X<~ƾ}AE凧2.
owo8z*nkq;6zɾWu&C