Physical Function, Frailty, Cognition, Depression, and Quality of Life in Hospitalized Adults >/=60 Years With Acute Decompensated Heart Failure With Preserved Versus Reduced Ejection Fraction

Citation:

Warraich HJ, Kitzman DW, Whellan DJ, Duncan PW, Mentz RJ, Pastva AM, Nelson MB, Upadhya B, Reeves GR. Physical Function, Frailty, Cognition, Depression, and Quality of Life in Hospitalized Adults >/=60 Years With Acute Decompensated Heart Failure With Preserved Versus Reduced Ejection Fraction. Circ Heart Fail. 2018;11 :e005254.

Date Published:

Nov

Abstract:

BACKGROUND: Older hospitalized acute decompensated heart failure (HF) patients have persistently poor outcomes and delayed recovery regardless of ejection fraction (EF). We hypothesized that impairments in physical function, frailty, cognition, mood, and quality of life (QoL) potentially contributing to poor clinical outcomes would be similarly severe in acute decompensated HF patients >/=60 years of age with preserved versus reduced EF (HFpEF and HFrEF). METHODS AND RESULTS: In 202 consecutive older (>/=60 years) hospitalized acute decompensated HF patients in a multicenter trial, we prospectively performed at baseline: short physical performance battery, 6-minute walk distance, frailty assessment, Geriatric Depression Scale, Montreal Cognitive Assessment, and QoL assessments. Older acute decompensated HFpEF (EF >/=45%, n=96) and HFrEF (EF <45%, n=106) patients had similar impairments in all physical function measures (short physical performance battery [5.9+/-0.3 versus 6.2+/-0.2]; 6-minute walk distance [184+/-10 versus 186+/-9 m]; and gait speed [0.60+/-0.02 versus 0.61+/-0.02 m/s]) and rates of frailty (55% versus 52%; P=0.70) and cognitive impairment (77% versus 81%; P=0.56) when adjusted for differences in sex, body mass index, and comorbidities. However, depression and QoL were consistently worse in HFpEF versus HFrEF. Depression was usually unrecognized clinically with 38% having Geriatric Depression Scale >/=5 and no documented history of depression. CONCLUSIONS: Patients >/=60 years hospitalized with acute decompensated HF patients have broad, marked impairments in physical function and high rates of frailty and impaired cognition: these impairments are similar in HFpEF versus HFrEF. Further, depression was common and QoL was reduced, and both were worse in HFpEF than HFrEF. Depression was usually unrecognized clinically. These findings suggest opportunities for novel interventions to improve these important patient-centered outcomes. CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov . Unique identifier: NCT02196038.

Notes:

Warraich, Haider JKitzman, Dalane WWhellan, David JDuncan, Pamela WMentz, Robert JPastva, Amy MNelson, M BenjaminUpadhya, BharathiReeves, Gordon RengR01 AG018915/AG/NIA NIH HHS/U24 AG059624/AG/NIA NIH HHS/KL2 TR001421/TR/NCATS NIH HHS/UL1 TR001420/TR/NCATS NIH HHS/R01 AG045551/AG/NIA NIH HHS/P30 AG028716/AG/NIA NIH HHS/P30 AG021332/AG/NIA NIH HHS/Research Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tCirc Heart Fail. 2018 Nov;11(11):e005254. doi: 10.1161/CIRCHEARTFAILURE.118.005254.