Hep C Calculator is an interactive tool developed to evaluate the cost-effectiveness of DAAs for the treatment of HCV globally. The tool utilizes a mathematical model to simulate the life course of HCV-infected populations in 28 countries (considered as priority countries by the World Health Organization). The natural history of HCV calculated using this model has been validated with the results of a multicenter follow-up study of patients with advanced fibrosis.
An input panel (on the left side) of the Hep C Calculator allows users to select a country, local price of DAAs and laboratory tests, annual cost of management of various HCV disease stages (health states), and patient characteristics. For each set of selected values, the outcomes of two strategies – treatment with DAAs versus no treatment – are compared. The user can thus evaluate in real-time the following outcomes for each strategy: total costs (including the cost of HCV treatment and of downstream events such as the development of cirrhosis), quality-adjusted life-years (QALYs), and the cumulative incidences of decompensated cirrhosis, liver cancer, and HCV-related deaths. The model uses the health sector perspective, and calculates the incremental cost-effectiveness ratio (ICER) to determine whether treatment with DAAs produces cost-effective or cost-saving results