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Jia-Ren Lin
Research fellow
Laboratory of Systems Pharmacology
Harvard Medical School
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2019
Wang S, Lin J-R, Sontag ED, Sorger PK
.
Inferring reaction network structure from single-cell, multiplex data, using toric systems theory
. bioRxiv. 2019 :731018.
Bandopadhayay P, Piccioni F, O’Rourke R, Ho P, Gonzalez EM, Buchan G, Qian K, Gionet G, Girard E, Coxon M
.
Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma
. Nature communications. 2019;10 (1) :2400.
2018
Elgart V, Lin J-R, Loscalzo J
.
Determinants of drug-target interactions at the single cell level
. PLoS computational biology. 2018;14 (12) :e1006601.
Jerby-Arnon L, Shah P, Cuoco MS, Rodman C, Su M-J, Melms JC, Leeson R, Kanodia A, Mei S, Lin J-R
.
A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade
. Cell. 2018;175 (4) :984-997. e24.
Jia-Ren Lin, Benjamin Izar SWCYSMPSSSPSMK
.
Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes
. eLIFE. 2018;7 :e31657.
Coy S, Rashid R, Lin J-R, Du Z, Donson AM, Hankinson TC, Foreman NK, Manley PE, Kieran MW, Reardon DA
.
Multiplexed Immunofluorescence Reveals Potential PD-1/PD-L1 Pathway Vulnerabilities in Craniopharyngioma
. Neuro-oncology. 2018 :noy035.
Herrera KGN, Zaganjor E, Ishikawa Y, Spinelli JB, Yoon H, Lin J-R, Satterstrom KF, Ringel A, Mulei S, Souza A
.
Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3
. Cell reports. 2018;22 (8) :1945-1955.
2017
Keenan AB, Jenkins SL, Jagodnik KM, Koplev S, He E, Torre D, Wang Z, Dohlman AB, Silverstein MC, Lachmann A
.
The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations
. Cell Systems. 2017.
Fallahi‐Sichani M, Becker V, Izar B, Baker GJ, Lin J‐R, Boswell SA, Shah P, Rotem A, Garraway LA, Sorger PK
.
Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de‐differentiated state
. Molecular Systems Biology. 2017;13 (1) :905.
2016
Lin J-R
.
Multiplexed Single-Cell Imaging: Past, Present, and Future
. ASSAY and Drug Development Technologies. 2016.
Publisher's Version
lin_adt_preprint.pdf
Lin J‐R, Fallahi‐Sichani M, Chen J‐Y, Sorger PK
.
Cyclic Immunofluorescence (CycIF), A Highly Multiplexed Method for Single‐cell Imaging
. Current Protocols in Chemical Biology. 2016 :251-264.
current_protocol_cycif_preprint.pdf
Tirosh I, Izar B, Prakadan SM, Wadsworth MH, Treacy D, Trombetta JJ, Rotem A, Rodman C, Lian C, Murphy G
.
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
. Science. 2016;352 (6282) :189-196.
2015
Lin J-R, Fallahi-Sichani M, Sorger PK
.
Highly multiplexed imaging of single cells using a high-throughput cyclic immunofluorescence method
. Nature Communications. 2015;6.
2014
Zeman MK, Lin J-R, Freire R, Cimprich KA
.
DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis
. The Journal of cell biology. 2014;206 (2) :183-197.
2013
Chen J-Y, Lin J-R, Tsai F-C, Meyer T
.
Dosage of Dyrk1a Shifts Cells within a p21-Cyclin D1 Signaling Map to Control the Decision to Enter the Cell Cycle
. Molecular cell. 2013;52 (1) :87-100.
Choi HJC, Lin J-R, Vannier J-B, Slaats GG, Kile AC, Paulsen RD, Manning DK, Beier DR, Giles RH, Boulton SJ
.
NEK8 links the ATR-regulated replication stress response and S phase CDK activity to renal ciliopathies
. Molecular cell. 2013;51 (4) :423-439.
2012
Chen J-Y, Lin J-R, Cimprich KA, Meyer T
.
A two-dimensional ERK-AKT signaling code for an NGF-triggered cell-fate decision
. Molecular cell. 2012;45 (2) :196-209.
2011
Lin J-R, Zeman MK, Chen J-Y, Yee M-C, Cimprich KA
.
SHPRH and HLTF act in a damage-specific manner to coordinate different forms of postreplication repair and prevent mutagenesis
. Molecular cell. 2011;42 (2) :237-249.
2008
Lin Y-M, Chen Y-R, Lin J-R, Wang W-J, Inoko A, Inagaki M, Wu Y-C, Chen R-H
.
eIF3k regulates apoptosis in epithelial cells by releasing caspase 3 from keratin-containing inclusions
. Journal of cell science. 2008;121 (14) :2382-2393.
2007
Gajendran VK, Lin J-R, Fyhrie DP
.
An application of bioinformatics and text mining to the discovery of novel genes related to bone biology
. Bone. 2007;40 (5) :1378-1388.
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Recent Publications
Inferring reaction network structure from single-cell, multiplex data, using toric systems theory
Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma
Determinants of drug-target interactions at the single cell level
Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3
Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes
Multiplexed Immunofluorescence Reveals Potential PD-1/PD-L1 Pathway Vulnerabilities in Craniopharyngioma
More