My current research focuses on the molecular dynamics of oncogene-induced senescence (OIS). By using a set of fluorescent reporters and single-cell time-lapse microscopy, I am trying to understand how variability in oncogenic activity, protein expression levels, etc. are linked to distinct cell fates, i.e., proliferation, transient cell cycle arrest and senescence.
My training began in my hometown, Taiwan, where I received my M.S. in Institute of Molecular Medicine at National Taiwan University and worked on programmed cell death in C. elegans. I then received my Ph.D. in Chemical and Systems Biology at Stanford supervised by Tobias Meyer. I combined single-cell image analysis, multi-parameter signal profiling, and high-content siRNA screening to understand how growth factor signals are translated by individual cells into a decision to proliferate or differentiate. I joined Galit Lahav’s lab at Harvard Medical School for postdoctoral training, and continue my long term interests in cell growth regulations. I expect that the knowledge gained from my postdoctoral work will allow us to understand how cell-to-cell variability at various levels contributes to the establishment of OIS, and explains how OIS is escaped in some cells. It can also be exploited for therapeutic utility to activate cellular senescence in cancer cells.