Biophysical attributes of an in vitro spinal cord surrogate for use in developing an intradural neuromodulation system

Citation:

Howard MA, Utz M, Brennan TJ, Dalm BD, Viljoen S, Kanwal JK, Gillies GT. Biophysical attributes of an in vitro spinal cord surrogate for use in developing an intradural neuromodulation system. Journal of Applied Physics. 2011;110 (7) :1-5.

Abstract:

We have developed a spinal cord surrogate for use in testing a pial-surface spinal cord stimulator. Our surrogate is of a commercially available silicone mix, has an oval cross-sectional area that matches that of actual human spinal cord at the lower thoracic level, and has measured values of durometer A = (10.96 ± 1.68), durometer O = (14.76 ± 1.48), and durometer OO = (50.24 ± 2.65). These correspond to model-inferred elastic moduli of 0.41 to 0.44 MPa, which match well with the existing low-strain rate measurements of ex vivo human spinal cord. Upcoming applications for this surrogate in developmental studies of the new stimulator system are discussed.

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Last updated on 02/13/2016