Design of core/shell alginate-silica/silica-titania beads as living drug delivery vessels for cell therapy of type I diabetes

Citation:

Julien Olivet. 1/20/2015. “Design of core/shell alginate-silica/silica-titania beads as living drug delivery vessels for cell therapy of type I diabetes.” Department of Chemistry, University of Namur, Namur, Belgium. Thesis Type: Master thesis in Materials Chemistry.

Abstract:

With the aim of finding new cell therapy technologies for autoimmune diseases like type 1 diabetes mellitus, this work reports the facile and rapid synthesis of fully-mineralized alginate-SiO2/SiO2-TiO2 core/shell beads, entrapping cells, under physiological conditions. The new material exhibited a well-tailored porosity to avoid entry of immune defenders while ensuring the diffusion of nutrients, gas, stimuli and therapeutic molecules. It also preserved the viability of model HepG2 cells over a period of at least 7 weeks and demonstrated an excellent mechanical resistance. These results highlighted the potentiality of using alginate-SiO2@SiO2-TiO2 beads as a new cell therapy technology to address autoimmune diseases like type 1 diabetes mellitus.

Last updated on 06/05/2019