lncRNAs in transcription regulatory bimolecular condensates

This week, two publsihed studies in Nature Publishing Group journals suggested a role for lncRNA in seeding phase-separated condensates on the active and repressed chromatin. In the first study, published in Nature Cell Biology, our group showed that the lncRNA DIGIT promotes the formation of BRD3 condensate on areas of the chromatin that are marked by H3K18ac. In the second study, authors show that the lncRNA Xist forms the Xi compartment by seeding a heteromeric condensate that consists of ubiquitous RNA-binding proteins. These new reports open new questions about the modes by which nulcear non-coding RNAs function to regulate gene expression and pave the way for new therapeutic modalities.