@article {472941,
	title = {Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models.},
	journal = {J Am Chem Soc},
	volume = {136},
	number = {12},
	year = {2014},
	month = {2014 Mar 26},
	pages = {4551-6},
	abstract = {Ferrostatin-1 (Fer-1) inhibits ferroptosis, a form of regulated, oxidative, nonapoptotic cell death. We found that Fer-1 inhibited cell death in cellular models of Huntington{\textquoteright}s disease (HD), periventricular leukomalacia (PVL), and kidney dysfunction; Fer-1 inhibited lipid peroxidation, but not mitochondrial reactive oxygen species formation or lysosomal membrane permeability. We developed a mechanistic model to explain the activity of Fer-1, which guided the development of ferrostatins with improved properties. These studies suggest numerous therapeutic uses for ferrostatins, and that lipid peroxidation mediates diverse disease phenotypes.},
	keywords = {Cell Death, Cyclohexylamines, Huntington Disease, Kidney Diseases, Leukomalacia, Periventricular, Lipid Peroxidation, Membrane Lipids, Oxidation-Reduction, Phenylenediamines},
	issn = {1520-5126},
	doi = {10.1021/ja411006a},
	author = {Skouta, Rachid and Dixon, Scott J and Wang, Jianlin and Dunn, Denise E and Orman, Marina and Shimada, Kenichi and Rosenberg, Paul A and Lo, Donald C and Weinberg, Joel M and Linkermann, Andreas and Stockwell, Brent R.}
}
