Abstract:

The eradication of smallpox is considered one of the greatest public health achievements of the twentieth century. Specimens of smallpox virus are, however, still officially held in the United States and Russia.

Samples of variola DNA may also be recoverable from old medical samples, such as the century-old smallpox scabs discovered in an envelope tucked in a 19th century medical textbook in a New Mexico library in 2004. In 2014, U.S. official found more smallpox samples in a storage room on the National Institutes for Health campus in Bethesda, Maryland.

The World Health Organization (WHO) declared smallpox eradicated in 1980. The last confirmed naturally occurring smallpox case was in 1977/ Ali Maow Maalin, a hospital employee in Merca, Somalia, survived his bout with smallpox.

Following eradication, the World Health Organization requested that all laboratories in the world either destroy their smallpox virus stocks or transfer them to one of two reference laboratories, the Institute of Viral Preparations in Moscow or the United States Centers for Disease Control and Prevention in Atlanta, Georgia. The stocks of the Institute of Viral Preparations were transferred in 1994 to the State Research Center of Virology and Biotechnology of the Russian Federation in Siberia, now the WHO Collaborating Centre for Orthopoxvirus Diagnostics. (download to read more)