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Talk at 19th Annual Meeting on Agent-Based Modeling & Simulation (SwarmFest 2015)

July 10, 2015

"Agent-based modeling in and of biomedicine: reconfiguring R&D"

Agent-based modeling (ABM) has been an active tool in complex systems research for at least two decades, and research using ABM tools and methodologies have expanded into fields far beyond their original home in computer science and artificial life[1]. ABM is now widely deployed across fields as disparate as archeology[2], social science[3], economics[4,5] and philosophy[6]. One field in which the uptake of ABM...

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Invited talk at National Cancer Institute on evolutionary and informatics approaches in bioscience and medicine

January 26, 2015

The combination of the increasing deluge of biological data, and the realization that evolutionary processes are important in disease pose challenges for translational biology.  In this talk I draw on population genetics, genomics and biomedical informatics in both human and yeast, focusing on approaches for examining evolution of resistance as well as practical tools for large-scale NGS sequencing analyses.  Epigenetically-inherited protein aggregates known as prions, can act as semi-stochastic "bet-hedging" switches that enable yeast cells to survive under extreme stress....

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