Within-sibling analysis: Fixed Effects Models (FEMs) (Workshop at the Department of Epidmeiology. Harvad TH Chan School of Public Health)

Presentation Date: 

Wednesday, September 30, 2015

Presentation Slides: 

Variance-component models (VCMs) are designed to model and estimate within-cluster correlations in the context of longitudinal and correlated data. In perinatal epidemiology, the effect of mothers on their siblings can be interpreted as being random or fixed. In this presentation, we assume that the effect of mothers is fixed (i.e.,it remains constant across pregnancies). Thus, all the genetic and environmental factors associated with mothersremain constant over time and each mother serves as her own control. In this talk a theoretical and applied overview of the fixed and mixed effect variance-component models is presented based on a perinatal epidemiology empirical example.