Mannstadt Lab

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Murine parathyroid gland

Parathyroid glands in mice with GFP driven by the 5.5 kb PTH promoter are green. Surrounding tissue is thyroid gland.
PTH-calcium curve

Treating mice expressing the diphtheria toxin (DT) receptor specifically in the parathyroids with DT.
Mouse Parathyroids are Tiny

Beta-galactosidase staining. The two tiny blue dots are the parathyroids (rodents only have 2) surrounded by thyroid tissue.
Painting Parathyroids Green

GFP under the control of the PTH promoter makes visualization of these small organs easy.
PTH-GFP

Parathyroids are bright green fluorescent with GFP expression under the control of the PTH promoter. Trachea in the middle.
The Endocrine Unit - Summer 2022
Mass General Hospital

Bulfinch Building. Designed by architect Charles Bulfinch. Built between 1818 and 1823. Home to the Ether Dome.
Meeting

1st International Hypoparathyroidism Meeting in Florence, Italy.
Meeting

1st International Hypoparathyroidism Meeting in Florence, Italy.
Dr. Michael Mannstadt at the ASBMR 2022 Annual Meeting Poster Session
Endocrine Unit Dinner during ASBMR 2022 meeting with current and former Endocrine Unit members
Congratulations to Dr. Marc Wein as Program Committee Co-Chair on a fantastic ASBMR meeting!
ASBMR 2022 Annual Meeting

International HypoPARAthyroidism Patient Conference

10/21/2022 (All day) to 10/23/2022 (All day)
First Gordon Conference on Phosphate Homeostasis

2/12/2023 (All day) to 2/17/2023 (All day)
2023 AIMM Meeting

4/3/2023 (All day) to 4/8/2023 (All day)
ENDO 2023 Annual Meeting

6/15/2023 (All day) to 6/18/2023 (All day)
ASBMR 2023 Annual Meeting

10/13/2023 (All day) to 10/16/2023 (All day)

My research focuses on the biology of the parathyroid glands, in particular on: (1) understanding the genetic basis of familial hypoparathyroidism; (2) defining the mechanisms by which the newly identified genes and pathways impact parathyroid function; (3) using these insights to improve treatment for parathyroid disorders.

Key discoveries of my group include dominant-negative mutations in the master transcription factor GCM2 in humans and the first description of germline activating mutation in the G protein Ga11 in patients with hypoparathyroidism. This led to our current...
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MMichael Cool technology! t.co/nUlWZBxxTE
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ValaAfshar This is a cyclist using his knowledge of physics and aerodynamics to gain a competitive advantage Michael Guerra unclips from his pedals, lies down on the seat and stretches out his legs to achieve ultimate aerodynamic efficiency. t.co/FUBFsvMbVk
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