Recent Photos

  • Help fight the pandemic

    Help fight the pandemic

  • Murine parathyroid gland

    Parathyroid glands in mice with GFP driven by the 5.5 kb PTH promoter are green. Surrounding tissue is thyroid gland.

  • PTH-calcium curve

    Treating mice expressing the diphtheria toxin (DT) receptor specifically in the parathyroids with DT.

  • Mass General Hospital

    Bulfinch Building. Designed by architect Charles Bulfinch. Built between 1818 and 1823. Home to the Ether Dome.

  • Mouse Parathyroids are Tiny

    Beta-galactosidase staining. The two tiny blue dots are the parathyroids (rodents only have 2) surrounded by thyroid tissue.

  • Painting Parathyroids Green

    GFP under the control of the PTH promoter makes visualization of these small organs easy.

  • Poster Session at the ASBMR

    David explaining his latest work.

  • Meeting

    1st International Hypoparathyroidism Meeting in Florence, Italy.

  • Meeting

    1st International Hypoparathyroidism Meeting in Florence, Italy.

  • PTH-GFP

    Parathyroids are bright green fluorescent with GFP expression under the control of the PTH promoter. Trachea in the middle.

  • Dr. Joy Tsai (left) and Emily Gentile (right)

    October 2017 National Osteoporosis Awareness Month

    Dr. Joy Tsai (left) and Emily Gentile (right)

  • Capital Hill Day_2018

    Capital Hill Day - February 2018

    Raising awareness for the importance of funding of biomedical research

  • Capital Hill Day - 2018 (2)

    Capital Hill Day - February 2018

    Raising awareness for the importance of funding of biomedical research

  • NIH K99/R00 Pathway to Independence Award_Lauren Surface

    NIH K99/R00 Pathway to Independence Award

    Lauren Surface, Ph.D., Endocrine Unit Research Fellow, recipient of the 2019 award

  • Summer Lunch

    Team Luncheon

    Clockwise: Michael Mannstadt, Han Xie, Lauren Surface, Samantha Bernstein, Ian Li, & Erin Bove-Fenderson

Events

Recent Publications

  • My research focuses on the biology of the parathyroid glands, in particular on: (1) understanding the genetic basis of familial hypoparathyroidism; (2) defining the mechanisms by which the newly identified genes and pathways impact parathyroid function; (3) using these insights to improve treatment for parathyroid disorders.

    Key discoveries of my group include dominant-negative mutations in the master transcription factor GCM2 in humans and the first description of germline activating mutation in the G protein Ga11 in patients with hypoparathyroidism.  This led to our current...

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