Frank C. Ko, Marie Mortreux, Daniela Riveros, Janice A. Nagy, Seward B Rutkove, and Mary L Bouxsein. 5/18/2020. “Dose-dependent skeletal deficits due to varied reductions in mechanical loading in rats.” npj Microgravity. Publisher's Version 2020_ko_et_al_-_npjmgrav_-_pwb_bone.pdf
Carson Semple, Daniela Riveros, Janice A Nagy, Seward B Rutkove, and Marie Mortreux. 4/3/2020. “Partial Weight-Bearing in Female Rats: Proof of concept in a Martian-Gravity Analog.” Frontiers in Physiology. Publisher's Version 2020_semple_et_al_frontiers_physiol_females.pdf
Marie Mortreux, Daniela Riveros, Carson Semple, Mary Bouxsein, and Seward Rutkove. 3/2020. “The Partial Weight-Bearing Rat Model Using a Pelvic Harness Does Not Impact Stress or Hindlimb Blood Flow.” Acta Astronautica, 168, Pp. 249-255. Publisher's VersionAbstract
Aim: Future space missions will send humans to the Moon and Mars, where gravity is greatly reduced compared
to Earth. The recent development of a rat partial weight-bearing (PWB) model allowed for a better understanding
of the changes induced by reduced loading.
Method: We exposed animals to 28 days of PWB including: normal loading without apparatus (PWB100 N),
normal loading with full apparatus (PWB100 FH), 70%, 40%, and 20% of normal loading (PWB70, PWB40, and
PWB20, respectively). We assessed physiological parameters weekly (i.e.: tail blood pressure, hindlimb oxygen
saturation, plasma corticosterone) to measure the impact of the apparatus during normal loading, and to determine
if PWB resulted in a dose-dependent modification of stress and/or hindlimb blood pressure. In addition,
we sought to determine if forelimb muscle atrophy could be detected.
Results: The use of the full apparatus did not impact any parameters compared to the control group during
normal loading, except for a reduced weight gain. PWB did not lead to significant modifications of animals’
blood pressure, blood oxygenation, or stress markers. Indeed, after 28 days of PWB, plasmatic corticosterone
levels were of 39.8 ± 12.0, 47.0 ± 16.9, 69.5 ± 14.4 and 55.9 ± 17.7 ng/mL in animals exposed to
PWB100, PWB70, PWB40 and PWB20, respectively (p = 0.7577).
Conclusion: These results support our hypothesis that our rat PWB system using a pelvic harness is well tolerated
by the animals and does not initiate a chronic-stress state that could mask other physiological alterations.
Marie Mortreux, Ewout Foppen, Raphael GP Denis, Mireia Montaner, Nadim Kassis, Jessica Denom, Mylene Vincent, Frederic Fumeron, Margaux Lafourcade, Fabrizio Adreeli, Beverley Backlau, Michel Marre, Ronan Roussel, Christophe Magnan, Hirac Gurden, and Stephanie Migrenne-Li. 11/2019. “New roles for Prokineticin 2 in feeding behavior, insulin resistance and type 2 diabetes: studies in mice and humans.” Molecular Metabolism, 29, Pp. 182-96. Publisher's Version 2019_mortreux_et_al_molecular_metabolism.pdf
Marie Mortreux, Carson Semple, Daniela Riveros, Janice A Nagy, and Seward B Rutkove. 10/1/2019. “Electrical impedance myography for the detection of muscle inflammation induced by λ-carrageenan.” PLoS One, 14, 10, Pp. e0223265. Publisher's Version 2019_mortreux_et_al_plos_one.pdf
Marie Mortreux, Frank C. Ko, Daniela Riveros, Mary L Bouxsein, and Seward B Rutkove. 8/22/2019. “Longitudinal time course of muscle impairments during partial weight-bearing in rats.” NPJ Microgravity, 5, Pp. 20. Publisher's Version mortreux_et_al_2019_-_nature_microgravity.pdf
Marie Mortreux, Daniela Riveros, Mary L Bouxsein, and Seward B Rutkove. 7/18/2019. “A Moderate Daily Dose of Resveratrol Mitigates Muscle Deconditioning in a Martian Gravity Analog.” Frontiers in Physiology, 10, Pp. 899. Publisher's Version mortreux_et_al_2019_frontiers_physiol.pdf
Marie Mortreux, Daniela Riveros, Mary L Bouxsein, and Seward B Rutkove. 4/4/2019. “Mimicking a Space Mission to Mars Using Hindlimb Unloading and PartialWeight Bearing in Rats.” Journal of Visualized Experiments, 146, e59327. mortreux_et_al._-_2019_-_mimicking_a_space_mission_to_mars_using_hindlimb_unloading_and_partial_weight_bearing_in_rats.pdf
Marie Mortreux, Janice A Nagy, Frank C Ko, Mary L Bouxsein, and Seward B Rutkove. 3/22/2018. “A novel partial gravity ground-based analog for rats via quadrupedalunloading.” Journal of Applied Physiology, 125, Pp. 175-182. jap_2018_mortreux_et_al.pdf
Marjorie Renon, Beatrice Legrand, Etienne Blanc, Fabrice Daubigney, Cindy Bokobza, Marie Mortreux, Jean-Louis Paul, Jean-Maurice Delabar, Helene Rouach, Karine Andreau, and Nathalie Janel. 5/20/2016. “Impact of Dyrk1A level on alcohol metabolism.” Biochimica et Biophysica Acta, 1862, Pp. 1495-1503. biochimica_et_biophysica_acta_2016_dyrk1a.pdf
Rana Abou-Khalil, Frank Yang, Marie Mortreux, Shirley Lieu, Yan-Yiu Yu, Maud Wurmser, Catia Pereira, Frederic Relaix, Theodore Miclau, Ralph S Marcucio, and Celine Colnot. 2/2014. “Delayed bone regeneration is linked to chronic inflammation inmurine muscular dystrophy.” Journal of Bone and Mineral Research, 29, 2, Pp. 304-315. jbmr_2014_dmdmdx.pdf