@article {650147,
	title = {E. coli SbcCD and RecA control chromosomal rearrangement induced by an interrupted palindrome},
	journal = {Mol Cell},
	volume = {39},
	number = {1},
	year = {2010},
	month = {2010 Jul 09},
	pages = {59-70},
	abstract = {Survival and genome stability are critical characteristics of healthy cells. DNA palindromes pose a threat to genome stability and have been shown to participate in a reaction leading to the formation of inverted chromosome duplications centered around themselves. There is considerable interest in the mechanism of this rearrangement given its likely contribution to genome instability in cancer cells. This study shows that formation of large inverted chromosome duplications can be observed in the chromosome of Escherichia coli. They are formed at the site of a 246 bp interrupted DNA palindrome in the absence of the hairpin nuclease SbcCD and the recombination protein RecA. The genetic requirements for this spontaneous rearrangement are consistent with a pathway involving DNA degradation and hairpin formation, as opposed to a cruciform cleavage pathway. Accordingly, the formation of palindrome-dependent hairpin intermediates can be induced by an adjacent DNA double-stand break.},
	keywords = {Base Pairing, Chromosomes, Bacterial, Deoxyribonucleases, DNA Breaks, Double-Stranded, DNA Replication, DNA, Bacterial, Escherichia coli, Escherichia coli Proteins, Exonucleases, Gene Rearrangement, Inverted Repeat Sequences, Microscopy, Models, Biological, Rec A Recombinases, Recombination, Genetic},
	issn = {1097-4164},
	doi = {10.1016/j.molcel.2010.06.011},
	author = {Darmon, Elise and Eykelenboom, John K and Lincker, Fr{\'e}d{\'e}ric and Jones, Lucy H and White, Martin and Okely, Ewa and Blackwood, John K and Leach, David R}
}
