@article {650148, title = {Non-random segregation of sister chromosomes in Escherichia coli}, journal = {Nature}, volume = {455}, number = {7217}, year = {2008}, month = {2008 Oct 30}, pages = {1248-50}, abstract = {It has long been known that the 5{\textquoteright} to 3{\textquoteright} polarity of DNA synthesis results in both a leading and lagging strand at all replication forks. Until now, however, there has been no evidence that leading or lagging strands are spatially organized in any way within a cell. Here we show that chromosome segregation in Escherichia coli is not random but is driven in a manner that results in the leading and lagging strands being addressed to particular cellular destinations. These destinations are consistent with the known patterns of chromosome segregation. Our work demonstrates a new level of organization relating to the replication and segregation of the E. coli chromosome.}, keywords = {Cephalexin, Chromosome Segregation, Chromosomes, Bacterial, Deoxyribonucleases, DNA Replication, DNA, Bacterial, Enzyme Induction, Escherichia coli, Escherichia coli Proteins, Exonucleases, Models, Biological}, issn = {1476-4687}, doi = {10.1038/nature07282}, author = {White, Martin A and Eykelenboom, John K and Lopez-Vernaza, Manuel A and Emily Wilson and Leach, David R F} }