Neural reorganization following sensory loss: the opportunity of change


Pascual-Leone A, Merabet LB. Neural reorganization following sensory loss: the opportunity of change. Nature reviews. Neuroscience. 2010;11 :44-52. Copy at

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There is growing evidence that sensory deprivation is associated with crossmodal neuroplastic changes in the brain. After visual or auditory deprivation, brain areas that are normally associated with the lost sense are recruited by spared sensory modalities. These changes underlie adaptive and compensatory behaviours in blind and deaf individuals. Although there are differences between these populations owing to the nature of the deprived sensory modality, there seem to be common principles regarding how the brain copes with sensory loss and the factors that influence neuroplastic changes. Here, we discuss crossmodal neuroplasticity with regards to behavioural adaptation after sensory deprivation and highlight the possibility of maladaptive consequences within the context of rehabilitation.


Merabet, Lotfi BPascual-Leone, AlvaroK 23 EY016131/EY/NEI NIH HHS/EnglandNat Rev Neurosci. 2010 Jan;11(1):44-52. Epub 2009 Nov 25.