@article {Li2016545,
	title = {Protein Prenylation Constitutes an Endogenous Brake on Axonal Growth},
	journal = {Cell Reports},
	volume = {16},
	number = {2},
	year = {2016},
	month = {July 12, 2016},
	pages = {545 - 558},
	abstract = {Summary Suboptimal axonal regeneration contributes to the\&nbsp;consequences of nervous system trauma and neurodegenerative disease, but the intrinsic mechanisms that regulate axon growth remain unclear. We screened 50,400 small molecules for their ability to promote axon outgrowth on inhibitory substrata. The most potent hits were the statins, which stimulated growth of all mouse- and human-patient-derived neurons tested, both in\&nbsp;vitro and in\&nbsp;vivo, as did combined inhibition of the protein prenylation enzymes farnesyltransferase (PFT) and geranylgeranyl transferase I (PGGT-1). Compensatory sprouting of motor axons may delay\&nbsp;clinical onset of amyotrophic lateral sclerosis (ALS).\&nbsp;Accordingly, elevated levels of PGGT1B, which would be predicted to reduce sprouting, were found in motor neurons of early- versus late-onset \ALS\ patients postmortem. The mevalonate-prenylation pathway therefore constitutes\&nbsp;an endogenous brake on axonal growth, and its inhibition provides a potential therapeutic approach to accelerate neuronal regeneration in humans.},
	issn = {2211-1247},
	doi = {http://dx.doi.org/10.1016/j.celrep.2016.06.013},
	url = {http://www.sciencedirect.com/science/article/pii/S2211124716307379},
	author = {Li, Hai and Takaaki Kuwajima and Derek Oakley and Nikulina, Elena and Hou, Jianwei and Wan~Seok Yang and Emily~Rhodes Lowry and Nuno~Jorge Lamas and Mackenzie~Weygandt Amoroso and Gist~F. Croft and Raghavendra Hosur and Wichterle, Hynek and Said Sebti and Marie~T. Filbin and Brent Stockwell and Christopher~E. Henderson}
}
