Publications

1975
Smith RJ, Bryant RG. Metal substitutions incarbonic anhydrase: a halide ion probe study. Biochem Biophys Res Commun 1975;66(4):1281-6.
Swett C. Outpatient phenothiazine use and bone marrow depression. A report from the drug epidemiology unit and the Boston collaborative drug surveillance program. Arch Gen Psychiatry 1975;32(11):1416-8.Abstract
Phenothiazine-induced bone marrow depression (BMD) was evaluated in three separate but complementary data bases: (1) Among 1,048 patients admitted to psychiatric hospitals, there was no evidence of subclinical depression of the white blood cell (WBC) count attributable to phenothiazines used before admission. (2) Among 18,587 medical inpatients, there were 34 patients admitted for BMD in the absence of neoplasia or prior cytotoxic drug therapy; one of the latter reported using chlorpromazine hydrochloride, but it is doubtful whether this drug was the cause of the BMD. (3) Among 24,795 medical, surgical, and gynecological patients surveyed over a ten-month period in 1972, there were four who were admitted for BMD; one of the latter had a reversible leukopenia attributed to trifluoperazine hydrochloride.
Cherkis MI. [Rate of distribution of pulse wave in patients with II-A stage hypertensive disease treated with artificial iodo-bromide baths under conditions of medium (Cholpon-Ata health resort) and low (city of Frunze) altitudes]. Zdravookhr Kirg 1975;(5):20-3.
Halaris AE, Belendiuk KT, Freedman DX. Antidepressant drugs affect dopamine uptake. Biochem Pharmacol 1975;24(20):1896-7.
Hendrickson WA, Ward KB. Atomic models for the polypeptide backbones of myohemerythrin and hemerythrin. Biochem Biophys Res Commun 1975;66(4):1349-56.
Boursnell JC, Noble EA, Andrews MG. Boar seminal zinc-precipitable protein and the haemagglutinin. J Reprod Fertil 1975;45(3):415-20.Abstract
About 30% of boar seminal plasma nitrogen is maximally precipitated at room temperature by 6 to 10 mM zinc in citrate solution at pH 8. A rise in the total nitrogen precipitated by 1 to 6 mM zinc is accompanied by a fall in the haemagglutinin titre of the supernatant fluid. At 6 mM zinc addition, 95% of the haemagglutinin is precipitated, but much of this is recoverable by re-solution of the zinc precipitate. Protein profile studies by gel-filtration chromatography of the zinc precipitate solution reveals a mixture of proteins, some of which are not by themselves zinc-precipitable.
Tarentino AL, Maley F. A comparison of the substrate specificities of endo-beta-N-acetylglucosaminidases from Streptomyces griseus and Diplococcus Pneumoniae. Biochem Biophys Res Commun 1975;67(1):455-62.
Schmoldt A, Benthe HF, Haberland G. Digitoxin metabolism by rat liver microsomes. Biochem Pharmacol 1975;24(17):1639-41.
Stein JM. The effect of adrenaline and of alpha- and beta-adrenergic blocking agents on ATP concentration and on incorporation of 32Pi into ATP in rat fat cells. Biochem Pharmacol 1975;24(18):1659-62.
Lefkowitz RJ. Identification of adenylate cyclase-coupled beta-adrenergic receptors with radiolabeled beta-adrenergic antagonists. Biochem Pharmacol 1975;24(18):1651-8.
Turner AJ, Hick PE. Inhibition of aldehyde reductase by acidic metabolites of the biogenic amines. Biochem Pharmacol 1975;24(18):1731-3.
Smith RC, Stricker CM. Nucleosides and nucleotides of the cold acid-soluble portion of the blood of steers. J Anim Sci 1975;41(6):1674-8.
Kidder GW, Montgomery CW. Oxygenation of frog gastric mucosa in vitro. Am J Physiol 1975;229(6):1510-3.Abstract
We have recently shown that 5% CO2/95% O2 in the serosal bathing solution, with 100% O2 in the mucosal solution, results in CO2-diffusion limitation of acid secretion in bullfrog gastric mucosa. Changing to 10% CO2/90% 02 on both surfaces doubles the acid secretory rate. We calculate that, were the rate of oxygen consumption to increase significantly as a result of secretory stimulation, the tissue would now be oxygen limited. This prediction is tested by raising the P02 by increasing the total pressure in a hyperbaric chamber. Since no change in acid secretory rate or potential difference was observed upon changing from PO2 = 0.9 to PO2 = 1.9 atm, we conclude that the tissue is not O2 limited at normal pressure. Decreasing PO2 below 0.9 atm, by contrast, decreases the acid secretory rate and raises both PD and resistance. We infer that the rate of oxygen consumption did not rise significantly when acid secretion was increased by supplying sufficient CO2.
Published
Non-uniform gastric wall kinematics revealed by 4D Cine magnetic resonance imaging in humans [Internet]. Neurogastroenterology & Motility Published;n/a(n/a):e14146. Publisher's VersionAbstract
Abstract Background Assessment of gastric function in humans has relied on modalities with varying degrees of invasiveness, which are usually limited to the evaluation of single aspects of gastric function, thus requiring patients to undergo a number of often invasive tests for a full clinical understanding. Therefore, the development of a non-invasive tool able to concurrently assess multiple aspects of gastric function is highly desirable for both research and clinical assessments of gastrointestinal (GI) function. Recently, technological advances in magnetic resonance imaging (MRI) have provided new tools for dynamic (or “cine”) body imaging. Such approaches can be extended to GI applications. Methods In the present work, we propose a non-invasive assessment of gastric function using a four-dimensional (4D, volumetric cine imaging), free-breathing MRI sequence with gadolinium-free contrast enhancement achieved through a food-based meal. In healthy subjects, we successfully estimated multiple parameters describing gastric emptying, motility, and peristalsis propagation patterns. Key Results Our data demonstrated non-uniform kinematics of the gastric wall during peristaltic contraction, highlighting the importance of using volumetric data to derive motility measures. Conclusions & Inferences MRI has the potential of becoming an important clinical and gastric physiology research tool, providing objective parameters for the evaluation of impaired gastric function.
Greater Somatosensory Afference with Acupuncture Increases Primary Somatosensory Connectivity and Alleviates Fibromyalgia Pain via Insular GABA: A Randomized Neuroimaging Trial [Internet]. Arthritis & Rheumatology Published;n/a(n/a) Publisher's VersionAbstract
Abstract Objective Acupuncture is a complex multi-component treatment that has shown promise for the treatment of Fibromyalgia (FM), however, clinical trials have shown mixed results, possibly due to heterogeneous methodology and lack of understanding of the underlying mechanism of action. We sought to understand the specific contribution of somatosensory afference to improvements in clinical pain, and the specific brain circuits involved. Methods 76 FM patients were randomized to receive 8 weeks (2 treatments/week) of electroacupuncture (EA, with somatosensory afference) or mock laser acupuncture (ML, with no somatosensory afference). Brief Pain Inventory (BPI) Severity, resting state functional MRI (rs-fMRI), and proton magnetic resonance spectroscopy (1H-MRS) in the right anterior insula (aINS) were collected at pre- and post-treatment. Results FM patients receiving EA experienced a greater reduction in pain severity compared to ML (mean difference, EA=-1.14, ML=-0.46, Group x Time interaction, p=0.036). Participants receiving EA, as compared to ML, also displayed increased resting functional connectivity between the primary somatosensory cortical representation of the leg (S1leg; i.e. S1 subregion activated by EA) and aINS. Increase in S1leg-aINS connectivity was associated with reductions in BPI severity (r=-0.44, p=0.01) and increases in aINS gamma-aminobutyric acid (GABA+) (r=-0.48, p=0.046) following EA. Moreover, increases in aINS GABA+ was associated with reductions in BPI severity (r=-0.59, p=0.01). Finally, post-EA changes in aINS GABA+ mediated the relationship between changes in S1leg-aINS and BPI severity, bootstrapped CI=[-0.533, -0.037]. Conclusion The somatosensory component of acupuncture modulates primary somatosensory functional connectivity in association with insular neurochemistry to reduce pain severity in FM.

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