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Whole grains are associated with serum concentrations of high sensitivity C-reactive protein among premenopausal women

Citation:

Audrey J Gaskins, Sunni L Mumford, Alisha J Rovner, Cuilin Zhang, Liwei Chen, Jean Wactawski-Wende, Neil J Perkins, and Enrique F Schisterman. 2010. “Whole grains are associated with serum concentrations of high sensitivity C-reactive protein among premenopausal women.” J Nutr, 140, 9, Pp. 1669-76.

Abstract:

In premenopausal women, elevated C-reactive protein (CRP) concentrations have been associated with an increased risk of negative reproductive outcomes. Whole grain consumption has been associated with lower CRP concentrations in older women; however, less is known about this relationship in younger women. We investigated whether whole grain intake was associated with serum high sensitivity CRP (hs-CRP) concentrations in young women. BioCycle was a prospective cohort study conducted at the University of Buffalo from 2005 to 2007, which followed 259 healthy women aged 18-44 y for or= 1 serving/d had 12.3% lower hs-CRP concentrations (P = 0.02) compared with nonconsumers. Women who consumed >or= 1 serving/d of whole grain had a lower probability of having moderate (P = 0.008) or elevated (P = 0.001) hs-CRP according to the AHA criteria compared with nonconsumers. Given that elevated concentrations of hs-CRP have been linked to adverse reproductive outcomes and pregnancy complications, interventions targeting whole grain consumption may have the potential to improve health status among young women.