Comparative effectiveness research: does one size fit all?

Citation:

Lauren M Kunz, Robert W Yeh, and Sharon-Lise T Normand. 2012. “Comparative effectiveness research: does one size fit all?” Stat Med, 31, 25, Pp. 3062-5; discussion 3066-7.

Abstract:

In this commentary, we argue that although randomization has many benefits, not all questions we seek to answer fit into a randomized setting. Our argument utilizes the clinical setting of carotid atherosclerosis management where specific clinical questions are answered by using a variety of comparative effectiveness designs. Observational studies should not be ruled out when designing studies to address questions of comparative effectiveness.