July 2020

Single-cell proteomics: Reviews & perspectives

Early experimental investigations of cellular heterogeneity used methods based on fluorescent proteins and antibodies, and these methods have been widely used for single-cell protein analysis over the last couple of decades. They have contributed to many foundational results discussed in this review. However, these methods limit both the number of proteins that can be analyzed and the specificity of the analysis. Furthermore, these methods are limited in their ability to quantify similar proteoforms. These limitations may be overcome by...

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