March 2022

Prioritized single-cell proteomics

While the sensitivity of mass spectrometry (MS) is often cited as a major limitation for single-cell proteomics, current methods can detect over 60 000 peptide-like features from individual cells analyzed by label-free MS. Yet, because of time constraints, shotgun methods can perform MS2 scans on only a fraction of all detected peptide-like features and identify the amino acid sequences of even a...

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