News

Advances in single-cell mass-spec enable high-throughput proteomics

April 21, 2018

In a news article entitled "Advances in Mass Spec Push Single-Cell Proteomics Toward Feasibility", GenomeWeb highlighted a mass-spec method for quantifying proteins in single cells (SCoPE-MS) that we have developed and the exciting new developments. Below are a few quotes:

"I think it's a very exciting time for [single-cell proteomics],"...

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Simpson's paradox in gene regulation

Simpson's paradox in gene regulation

May 22, 2017

The identity of human tissues depends on their protein levels. Are tissue protein levels set largely by corresponding mRNA levels or by other (post-transcriptional) regulatory mechanisms? We revisit this question based on statistical analysis of mRNA and protein levels measured across human tissues. We find that for any one gene, its protein levels across tissues are poorly predicted by its mRNA levels, suggesting tissue-specific post-transcriptional regulation. In contrast, the overall protein levels are well predicted by scaled mRNA levels. We show how these speciously contradictory...

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