The existence of eukaryotic ribosomes with distinct ribosomal protein (RP) stoichiometry and regulatory roles in protein synthesis has been speculated for over 60 years. Recent advances in mass spectrometry (MS) and high-throughput analysis have begun to identify and characterize distinct ribosome stoichiometry in yeast and mammalian systems. In addition to RP stoichiometry, ribosomes host a vast array of protein modifications, effectively expanding the number of human RPs from 80 to many thousands of distinct proteoforms. Is it possible that these proteoforms combine to function as a ‘ribosome code’ to tune protein synthesis? We outline the specific benefits that translational regulation by specialized ribosomes can offer and discuss the means and methodologies available to correlate and characterize RP stoichiometry with function. We highlight previous research with a focus on formulating hypotheses that can guide future experiments and crack the ribosome code.
slavovLab@galos_gann Another problem with such comments is that they can be obfuscated in convolute technical jargon, making them rather hard for professional editors to evaluate. They just make everybody's life harder for no good reason.
slavovLab@rmounce Perhaps the the questions over the credibility of #OA journals are raised my parties having selfish interests to undermine the march of #OA and preserve as long as possible the system that nourishes them.
slavovLab@galos_gann The point of peer review is constructive feedback, not highly-technical comments intended to confuse.
I raise this publicly because I think it's poisonous for the community. It's counterproductive. It's sad. It's pathetic.