We are a neuroscience research lab focused on mechanisms, biomarkers, and therapeutic strategies for sensory disorders.
We are particularly interested in the neural basis for phantom sound perception (e.g., tinnitus) and sound-triggered hypersensitivity, distress, or pain (e.g., hyperacusis). These chronic sensory disorders impose an enormous societal burden and are a source of great frustration and distress for patients and clinicians alike because they are so common, yet have no objective biomarkers or widely effective treatments. Our lab is exploring new therapeutic avenues for these sensory overload disorders that leverage the brain’s endogenous "pre-wired" systems for plasticity and neuromodulation to turn down neural hyperactivity and restore more normal sensation and perception. We pursue our work jointly at the scale of neural circuits in animal models at the level of integrated systems in human subjects.
Apart from these research objectives, a core mission for our lab is to train the next generation of leaders in our field. Our lab is physically part of the Eaton-Peabody Laboratories, the world's largest research center for the study of hearing and deafness, at the Massachusetts Eye and Ear, near the historic Beacon Hill district of Boston. Our lab is home to a multinational group of staff scientists, postdoctoral trainees, and faculty affiliated with the Department of Otolaryngology - Head and Neck Surgery at Harvard Medical School. Predoctoral trainees pursue their dissertation research in our lab through the Harvard Program in Neuroscience or the Harvard Program in Speech and Hearing Bioscience and Technology Programs.