Mouro Pinto Lab

We are interested in repeat expansion-associated neurodegenerative disorders, such as Huntington’s disease and Friedreich Ataxia, with a major focus on characterizing the mechanisms responsible for somatic repeat instability as potential therapeutic targets. We use both mouse and patient-derived cellular models, in combination with genome engineering tools, viral-based delivery techniques and next-generation sequencing, to develop methods for unbiased quantification of long somatic repeat expansions, identify novel biomarkers and disease modifiers genes, and ultimately develop new therapies for these devastating disorders.

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We are seeking highly motivated post-doctoral fellow candidates. Candidates must hold a Ph.D. in Biology, Genetics, Neuroscience or other closely related fields, or an M.D. with relevant research experience. Desirable skills include expertise in any of the following: molecular biology and cloning techniques, animal handling and in vivo research, mammalian cell culturing (preference for experience in iPSC differentiation), gene expression analysis (preference for RNA-Seq and single cell experience), immunohistochemistry, CRISPR/Cas9-based gene editing, AAV design, biomarker discovery, exosome and extracellular vesicle isolation, as well as bioinformatics and computational biology. We offer competitive pay at or above NIH recommended level and assistance with visa application for international candidates. Interested applicants should contact Dr. Mouro Pinto directly with a copy of their CV/Biosketch, a summary of research accomplishments, and a brief description of research interests and career goals